| mice, neurologic mutants | Mice which carry mutant genes for neurologic defects or abnormalities. (12 Dec 1998) |
|---|---|
| mice, nude | Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumour studies and studies on immune responses. (12 Dec 1998) |
| mice, obese | Mutant mice exhibiting a marked obesity coupled with overeating, hyperglycaemia, hyperinsulinaemia, marked insulin resistance, and infertility when in a homozygous state. They may be inbred or hybrid. (12 Dec 1998) |
| mice, quaking | Mice homozygous for the mutant autosomal recessive gene, quaking (qk), associated with disorder in myelin formation and manifested by axial tremors. (12 Dec 1998) |
| mice, scid | Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of b- and T-cell immunity resembles severe combined immunodeficiency (scid) syndrome in human infants. Scid mice are useful as animal models since they are receptive to implantation of a human immune system producing scid-human (scid-hu) haematochimeric mice. (12 Dec 1998) |
| mice, transgenic | Laboratory mice that have been produced from a genetically manipulated egg or embryo. The technique involves microinjection of foreign DNA fragments into the nucleus of the fertilised egg and transferring it into the uterus of a foster mother mouse. The inserted gene becomes integrated into every cell and tissue of the developing mouse, including its germ line cells. (12 Dec 1998) |
| pneumonia virus of mice | An RNA virus of the genus Pneumovirus, a member of the family Paramyxoviridae, occurring normally as latent infection in laboratory mice, but capable of activation by serial intranasal passage and causing pneumonia. Synonym: PVM virus. (05 Mar 2000) |
| SCID mice | <abbreviation> Severe combined immunodeficient mice. (05 Mar 2000) |
| severe combined immunodeficient mice | Mice that lack both T and B lymphocytes and are used for transplantation and study of human lymphoid tissues resulting in a SCID-human mouse chimera. See: severe combined immunodeficiency. (05 Mar 2000) |
| New Zealand mice | Inbred strains of mice, either black (NZB) or white (NZW), unique among strains used in experimental immunology because of their proclivity to spontaneous immunologic abnormalities and disorders including systemic lupus erythematosus similar to that found in humans. (05 Mar 2000) |
| NOD mice | Nonobese diabetic mice. Have unique histocompatibility antigens, pancreatic beta cells are destroyed by an autoimmune response. (14 Oct 1997) |
| nude mice | Strains of athymic mice bearing the recessive allele nu/nu which are largely hairless and lack all or most of the T-cell population. Show no rejection of either allografts or xenografts. Nu/nu alleles on some backgrounds have near normal numbers of T-cells. (18 Nov 1997) |
| transgenic mice | Mice that have a piece of foreign lincor DNA integrated into their genome. (05 Mar 2000) |
| acromioclavicular joint | The joint formed by the acromion of the scapula and the acromial extremity of the clavicle. (12 Dec 1998) |
| ankle joint | The joint that is formed by the inferior articular and malleolar articular surfaces of the tibia, the malleolar articular surface of the fibula, and the medial malleolar, lateral malleolar, and superior surfaces of the talus. (12 Dec 1998) |