| human immunodeficiency virus | <virology> A type of retrovirus (human immunodeficiency virus) that is responsible for the fatal illness acquired immunodeficiency syndrome. Two strains have been identified. Type 1: the retrovirus recognised as the agent that induces AIDS. Type 2: a virus closely related to HIV-1 that also leads to immune suppression. HIV-2 is not as virulent as HIV-1 and is epidemic only in West Africa. Acronym: HIV (11 Nov 1997) |
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| severe combined immunodeficiency | Group of rare congenital disorders characterised by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an x-linked or autosomal recessive defect. About half of the patients with autosomal recessive scid are deficient in the enzyme adenosine deaminase. (12 Dec 1998) |
| simian immunodeficiency virus | <virology> A retrovirus found in monkeys that is closely related to HIV. (09 Oct 1997) |
| immunodeficiency | Inabillity to mount a normal immune response. Immunodeficiency can be due to a genetic disease or acquired as in aids due to HIV. (12 Dec 1998) |
| immunodeficiency disorders | <radiology> B-cell (antibody) deficiency: high-grade pathogens: pneumococcus, strep, H. Flu, chronic sinopulmonary disease, usual survival to adulthood, T-cell (cellular) deficiency: low-grade pathogens: fungi, viruses, Pneumocystic, growth retardation, diarrhoea, delayed anergy, short life-span, susceptible to graft vs. Host (GvH) disease, e.g.: DiGeorge syndrome, Nezelhof syndrome Note: increased risk of malignancy (12 Dec 1998) |
| immunodeficiency virus, bovine | A species of lentivirus, subgenus bovine lentiviruses (lentiviruses, bovine), found in cattle and causing lymphadenopathy, lymphocytosis, central nervous system lesions, progressive weakness, and emaciation. It has immunological cross-reactivity with other lentiviruses including HIV. (12 Dec 1998) |
| immunodeficiency virus, feline | A species of lentivirus, subgenus feline lentiviruses (lentiviruses, feline) isolated from cats with a chronic wasting syndrome, presumed to be immune deficiency. There is no antigenic relationship between fiv and HIV, nor does fiv grow in human T-cells. (12 Dec 1998) |
| immunodeficiency with elevated IgM | Immunodeficiency with reduced IgG and IgA-bearing cells; there is recurrent pyogenic infection; X-linked in some families. (05 Mar 2000) |
| immunodeficiency with hypoparathyroidism | diGeorge syndrome |
| feline immunodeficiency virus | A lentivirus causing acquired immunodeficiency in cats. (05 Mar 2000) |
| Aarskog-Scott syndrome | A syndrome of ocular hypertelorism, anteverted nostrils, broad upper lip, saddle-bag scrotum, and laxity of ligaments resulting in genu recurvatum, flat feet, and hyperextensible fingers; X-linked and autosomal dominant forms. Synonym: Aarskog-Scott syndrome. (05 Mar 2000) |
| Aarskog syndrome | <syndrome> Grier et al. (1983) reported father and 2 sons with typical Aarskog syndrome, including short stature, hypertelorism, and shawl scrotum. They tabulated the findings in 82 previous cases. X-linked recessive inheritance has been repeatedly suggested. The family reported by Welch (1974) had affected males in 3 consecutive generations. Thus, there is either genetic heterogeneity or this is an autosomal dominant with strong sex-influence and possibly ascertainment bias resulting from use of the shawl scrotum as a main criterion. Stretchable skin was present in the cases of Grier et al. (1983). Teebi et al. (1993) reported the case of an affected mother and 4 sons (including a pair of monozygotic twins) by 2 different husbands. They suggested that the manifestations were as severe in the mother as in the sons and that this suggested autosomal dominant inheritance. Actually, the mother seemed less severely affected, compatible with X-linked inheritance. Clinical signs: Mild to moderate short stature,normocephaly, Widow's peak hair, maxillary hypoplasia, broad nasal bridge, anteverted nostrils, long philtrum, broad upper lip, curved linear dimple below the lower lip, hypertelorism, ptosis, down-slanted palpebral fissures, ophthalmoplegia, strabismus, hyperopic astigmatism, large cornea, floppy ears, lop-ears,cleft lip/palate, shawl scrotum, saddle-bag scrotum, cryptorchidism, brachydactyly, digital contractures, clinodactyly, mild syndactyly, transverse palmar crease, lymphoedema of the feet, ligamentous laxity, osteochondritis dissecans, proximal finger joint hyperextensibility, flexed distal finger joints, genu recurvatum, flat feet, stretchable skin, cervical spine hypermobility, odontoid anomaly, macrocytic anaemia, hemochromatosis, hepatomegaly, portal cirrhosis, imperforate anus, rectoperineal fistula, interstitial pulmonary disease, sternal deformity. Inheritance: Sex-influenced autosomal dominant form, also X-linked form. (05 Aug 1998) |
| abdominal muscle deficiency syndrome | <syndrome> Congenital absence (partial or complete) of abdominal muscles, in which the outline of the intestines is visible through the protruding abdominal wall; in males, genitourinary anomalies (urinary tract dilation and cryptorchidism) are also found; genetics unclear. (05 Mar 2000) |
| abstinence syndrome | <syndrome> A constellation of physiologic changes undergone by persons or animals who have become physically dependent on a drug or chemical due to prolonged use at elevated doses, but who are abruptly deprived of that substance. The abstinence syndrome varies with the drug to which dependence has developed. Generally the effects observed are in an opposite direction from those produced by the drug; e.g., the withdrawal syndrome from central nervous system depressants such as barbiturates and benzodiazepines consists of insomnia, restlessness, tremulousness, hallucinations, and, in the extreme, tonic-clonic convulsions which may prove fatal. The onset time and severity of the abstinence syndrome depend upon how rapidly the drug disappears from the body. (05 Mar 2000) |
| Achard syndrome | <syndrome> Arachnodactyly with small receding mandible, broad skull, and joint laxity limited to the hands and feet; genetics unclear. (05 Mar 2000) |