| hydroxychloroquine | <drug> A drug used to treat and prevent malaria and to treat the symptoms of lupus erythematosus. It is also used to treat rheumatoid arthritis when used in combination with other drugs. It has the chemical formula of C18H26ClN3O. (09 Oct 1997) |
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| hydroxychloroquine sulfate | A quinoline derivative; an antimalarial agent whose actions and uses resemble those of chloroquine phosphate; also used in the treatment of lupus erythematosus and rheumatoid arthritis. (05 Mar 2000) |
| hydroxycholanoyl dehydroxylase | <enzyme> Removes hydroxyl group with formation of water and double bond Registry number: EC 4.2.1.- (26 Jun 1999) |
| hydroxycholecalciferols | Hydroxy analogs of vitamin d 3. (cholecalciferol). Members of this group include calcifediol, calcitriol, and 24,25-dihydroxyvitamin d 3. (12 Dec 1998) |
| hydroxycholesterol 25-hydroxylase | <enzyme> Acts on 22r-hydroxycholesterol and 20s-hydroxycholesterol Registry number: EC 1.14.99.- Synonym: 25-hydroxylase (26 Jun 1999) |
| hydroxycholesterols | Cholesterol which is substituted by a hydroxy group in any position. (12 Dec 1998) |
| hydroxychroman | 6-Hydroxychroman (6-chromanol) is the fundamental unit of the tocopherols (vitamin E), tocols, and tocotrienols, as well as of ubi-, toco-, and phyllochromanol. See: chroman, chromene, chromenol. Synonym: hydroxychroman. (05 Mar 2000) |
| hydroxychromene | 6-hydroxychromene (6-chromenol) is the fundamental unit of the tocopherolquinones (oxidised tocopherol) and plastochromenol-8. See: chroman, chromanol, chromene. Synonym: hydroxychromene. (05 Mar 2000) |
| hydroxycinnamoyl-CoA-tyramine N-(hydroxycinnamoyl)transferase | <enzyme> Catalyses synthesis of n-(hydroxycinnamoyl)tyramine; isolated from nicotiana tabacum Registry number: EC 2.3.1.- Synonym: tht enzyme (26 Jun 1999) |
| hydroxycorticosteroids | A group of corticosteroids carrying hydroxy groups, usually in the 11- or 17-positions. They comprise the bulk of the corticosteroids used systemically. As they are relatively insoluble in water, salts of various esterified forms are often used for injections or solutions. (12 Dec 1998) |
| hydroxydopamines | Dopamines with a hydroxy group substituted in one or more positions. (12 Dec 1998) |
| hydroxyeicosatetraenoic acids | Eicosatetraenoic acids substituted in any position by one or more hydroxy groups. They are important intermediates in a series of biosynthetic processes leading from arachidonic acid to a number of biologically active compounds such as prostaglandins, thromboxanes, and leukotrienes. (12 Dec 1998) |
| hydroxyephedrine | P-Hydroxy-alpha-[1-(methylamino)ethyl]benzyl alcohol;a sympathomimetic agent for the treatment of shock. (05 Mar 2000) |
| hydroxyestrones | Hydroxyestra-1,3,5(10)-trien-17-ones. Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other oestrogens. (12 Dec 1998) |
| hydroxyethylrutoside | Monohydroxyethyl derivative of rutin. Peripheral circulation stimulant used in treatment of venous disorders. (12 Dec 1998) |
| 2-hydroxy-3-oxoadipate synthase | <enzyme> Deficient in hyperoxaluria type i Registry number: EC 4.1.3.15 Synonym: 2-ketoglutarate-glyoxylate carboligase, glyoxylate-oxoglutarate carboligase, delta-hydroxylaevulinate synthase, 2-oxoglutarate-glyoxylate carboligase, 2-hydroxy-3-oxoadipate carboxylase (26 Jun 1999) |
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| 2-hydroxy-3-oxopropionate reductase | <enzyme> Catalyses reversibly the reduction of glycerate to 2-hydroxy-3-oxopropanate in the presence of nad(p+) Registry number: EC 1.1.1.60 Synonym: tartronate saemialdehyde reductase, tsa reductase (26 Jun 1999) |
| 2-hydroxy-4-carboxymucconate-6-saemialdehyde dehydrogenase | <enzyme> Catalyses alpha-hydroxy-gamma-carboxymuconic-epsilon-saemialdehyde to alpha-hydroxy-gamma-carboxymuconic acid Registry number: EC 1.2.1.45 Synonym: alpha-hydroxy-gamma-carboxymuconic-epsilon-saemialdehyde dehydrogenase, chms dehydrogenase (26 Jun 1999) |
| 2-hydroxy-5-nitrobenzyl bromide | <chemical> 2-(bromomethyl)-5-nitrophenol. A chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules. Used for 'active site' enzyme studies and other protein studies. Sometimes referred to as koshland's reagent. Pharmacological action: indicators and reagents. Chemical name: Phenol, 2-(bromomethyl)-4-nitro- (12 Dec 1998) |
| 2-hydroxy-6-oxo-2,4-heptadienoate hydrolase | <enzyme> Above cpd hydrolyzed to 2-oxopent-4-enoate (2-hydroxypenta-2,4-dienoate); enzyme e of p-cumate catabolic pathway in pseudomonas putida Registry number: EC 3.7.- Synonym: hodh hydrolase, 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase, cmte gene product (26 Jun 1999) |
| 2-hydroxy-isonicotinic acid hydroxylase | <enzyme> Forms 2,6-dihydroxy-isonicotinic acid (citrazinic acid); contains iron and a flavin; incorporates hydroxyl group of water Registry number: EC 1.- Synonym: hinah (26 Jun 1999) |
| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase | <enzyme> E coli enzyme; catalyses formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate from 2-ketoglutarate and isochorismate; requires thiamine pyrophosphate and liberates pyruvate from the isochorismate molecule; see also o-succinylbenzoate synthase Registry number: EC 4.1.3.- Synonym: shchc synthase (26 Jun 1999) |
| 3a-hydroxy-5a-pregnan-20-one | A catabolite of progesterone; found in the urine of pregnant women. (05 Mar 2000) |
| 3 beta-hydroxy-delta 5-C(27)-steroid dehydrogenase | <enzyme> Second enzyme in the sequence that converts cholesterol to bile acids; deficiency leads to chronic liver disease in childhood Registry number: EC 1.1.1.- Synonym: 7 alpha-hydroxycholesterol 3 beta-dehydrogenase, 7-hydroxycholesterol 3-dehydrogenase, 3 beta-hydroxy-delta(5)-c(27)-steroid oxidoreductase, 5-cholestene-3beta,7alpha-diol oxidase (26 Jun 1999) |
| 3-hydroxy-2-methylpropionyl-CoA dehydrogenase | <enzyme> Forms methylmalonyl-CoA saemialdehyde Registry number: EC 1.1.1.- Synonym: 3-hydroxyisobutyryl-CoA dehydrogenase (26 Jun 1999) |
| 3-hydroxy-2-pyrrolidinecarboxylic acid | A derivative of proline found in certain collagens, particularly basement membrane collagen. Synonym: 3-hydroxy-2-pyrrolidinecarboxylic acid. (05 Mar 2000) |
| 3-hydroxy-3-methylglutaryl-CoA | -OOCCH2C(OH)(CH3)CH2COS-CoA;a key intermediate in the synthesis of ketone bodies and of steroids. Synonym: 3-hydroxy-3-methylglutaryl-CoA. Beta-hydroxy-beta-methylglutaryl-lyase, an enzyme, found primarily in liver and rumen epithelium that catalyses the formation of acetyl-CoA and acetoacetate from beta-hydroxy-beta-methylglutaryl-CoA; a key step in ketogenesis; a deficiency of this enzyme leads to episodes of severe metabolic acidosis without ketosis. Beta-hydroxy-beta-methylglutaryl-reductase, an enzyme that catalyses the rate-limiting step of cholesterol biosynthesis, beta-hydroxy-beta-methylglutaryl-CoA + 2NADPH + 2H+ → mevalonate + 2NADP+ + coenzyme A. Beta-hydroxy-beta-methylglutaryl-synthase, an enzyme in mitochondria that catalyses the reaction of acetyl-CoA with acetoacetyl-CoA and water to form beta-hydroxy-beta-methylglutaryl-CoA and coenzyme A, a step required for both ketogenesis and steroidogenesis to occur. (05 Mar 2000) |
| 3-hydroxy-4-oxoquinoline oxygenase | <enzyme> Forms n-formylanthranilic acid + co2; 24 amino acids of n-terminal sequence given in first source Registry number: EC 1.13.12.- Synonym: 1h-3-hydroxy-4-oxoquinoline oxygenase, 3-oh-4-oxoquinoline oxygenase (26 Jun 1999) |
| 4-(4'-hydroxy-3'-methylbut-2'-enyl)-L-tryptophan synthetase | <enzyme> Enzymatic synthesis of above cpd from isopentenylpyrophosphate and tryptophan Registry number: EC 6.- (26 Jun 1999) |
| 4-hydroxy-2-ketopimelate aldolase | <enzyme> Bacterial enzyme functioning in pathways of aromatic catabolism; forms pyruvate and succinic saemialdehyde Registry number: EC 4.1.3.- (26 Jun 1999) |