| growth hormone-producing adenoma | <tumour> An adenoma that produces the clinical picture of gigantism or acromegaly, although a third of the cells have no granules or are a mixture of acidophils and chromophobes; some tumours may secrete both growth hormone and prolactin; often an acidophil or eosinophil adenoma. (05 Mar 2000) |
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| growth hormone-regulating hormone | <endocrinology> Hypothalamic hormones that induce (somatoliberin) or inhibit (somatostatin) the release of growth hormone (somatotropin). (18 Nov 1997) |
| growth hormone-releasing factor | <endocrinology> Peptide hormone related to the glucagon family, released from the pituitary, acts on the adenohypophysis to release growth hormone. Synonym: somatoliberin, growth hormone-releasing factor. (20 Sep 2002) |
| growth hormone-releasing hormone | <endocrinology> Peptide hormone related to the glucagon family, released from the pituitary, acts on the adenohypophysis to release growth hormone. Synonym: somatoliberin, growth hormone-releasing factor. (20 Sep 2002) |
| growth inhibitors | Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= plant growth regulators). (12 Dec 1998) |
| growth medium | <cell culture> A synthetic medium which is filled with nutrients necessary to the growth of microorganisms or cells being cultured in the lab. (09 Oct 1997) |
| growth milestones | <paediatrics> (1-3 years) In ascending order: masters walking, recognises gender differences, uses up to 8 words and understands simple commands, able to run, pivot and walk backwards, uses spoon to feed self, can name pictures of common objects, can point to body parts, imitates speech of others, begins pedaling tricycle, learns to take turns in play with other children, able to feed self neatly with minimal spill, able to say first and last name, able to draw a line when shown, dresses self with minimal help, learns to share toys without parent direction (12-18 years) In ascending order: boys exhibit secondary sexual characteristics (chest, facial, axillary and pubic hair growth voice changes, penile enlargement), movement into adult height/weight category, cognitive abilities move from simply concrete to abstract, peer acceptance and recognition is vital (3-6 years) In ascending order: rides tricycle well, able to draw a circle, able to draw stick figures, hops on one foot, catches a bounced ball, understands size concepts, enjoys rhymes and word play, able to skip, increased independence in performing tasks without parental assistance, begins to ride bicycle, understands time concepts, begins to recognise written words, starts reading skills, starts school (6-12 years) In ascending order: understands and is able to follow sequential directions, beginning skills for team sports, begins to lose baby teeth and erupt permanent teeth, reading skills develop further, peer recognition becomes important, girls begin to demonstrate secondary sexual characteristics (pubic hair, axillary hair, breast development), first menstrual period may occur (birth-1 year) In ascending order: displays social smile, rolls over by self, able to sit alone without support, babbling, plays peek-a-boo, eruption of first tooth, pulls self to standing position, walks while holding on to furniture or other support, says mama or dada in proper situations, able to drink from cup, understands NO and will stop activity in response, walks without support (27 Sep 1997) |
| growth phase | <microbiology> The characteristic periods in the growth of a bacterial culture, as indicated by the shape of a graph of viable cell number versus time. (09 Oct 1997) |
| growth plate | <physiology> The area between the epiphysis and the diaphysis within which bone growth occurs. (12 Dec 1998) |
| growth quotient | <biology> The fractional part or percentage of the entire food energy which is utilised for growth in the young animal. (05 Mar 2000) |
| growth rate | <biology, cell culture, ecology> The rate, or speed, at which the number of organisms in a population increases. This can be calculated by dividing the change in the number of organisms from one point in time to another by the amount of time in the interval between the points of time. The phrase is most often used to describe growth of cells or microorganisms in laboratory cultures and usually expressed as the generation time. (21 Jun 2000) |
| growth rate of population | <epidemiology> A measure of population change in the absence of migration, comprising addition of newborns and subtraction of deaths; the result is known as the natural rate of increase of the population; it is the difference between the crude birth rate and the crude death rate. (05 Mar 2000) |
| growth substance | <biology, cell biology> Signal molecules that are involved in the control of cell growth and differentiation. (12 Dec 1998) |
| growth-onset diabetes | A chronic condition in which the pancreas makes little or no insulin because the beta cells have been destroyed. The body is then not able to use the glucose (blood sugar) for energy. IDDM usually comes on abruptly, although the damage to the beta cells may begin much earlier. The signs of IDDM are a great thirst, hunger, a need to urinate often, and loss of weight. To treat the disease, the person must inject insulin, follow a diet plan, exercise daily, and test blood glucose several times a day. IDDM usually occurs in children and adults who are under age 30. This type of diabetes used to be known as juvenile diabetes, juvenile-onset diabetes, and ketosis-prone diabetes. (09 Oct 1997) |
| receptors, insulin-like-growth factor I | Specific proteins on or in cells to which insulin-like growth factor I (somatomedin c) binds and thereby modifies the function of the cells. These receptors contain transmembrane and cytosolic domains, bind igf-I preferentially, and have high-affinity sites for igf-II. The alpha-subunit has a mw of 130 kD and the beta subunit possesses tyrosine kinase activity. (12 Dec 1998) |
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| receptors, insulin-like-growth-factor II | Specific proteins on or in cells to which insulin-like growth factor II and mannose-6-phosphate bind and thereby modify the function of the cells. These receptors have a mw of 250 kD and possess no tyrosine kinase activity. (12 Dec 1998) |
| receptors, nerve growth factor | Cell surface receptors that bind nerve growth factor (ngf) and trigger intracellular changes influencing the behaviour of cells. Nerve growth factor receptors mediate the effects of nerve growth factor on the survival and growth of neurons. (12 Dec 1998) |
| receptors, platelet-derived growth factor | Specific molecular sites or structures on cell membranes that react with platelet-derived growth factor, its analogs, or antagonists, to elicit or to inhibit the specific response of the cell to this factor. Pdgf binds with different affinities and specificities to two structurally related receptors, the alpha-receptor and the beta-receptor. Both of these receptors are transmembrane proteins with an intracellular, ligand-stimulatable protein kinase domain. (12 Dec 1998) |
| receptors, transforming growth factor beta | Cell-surface proteins that bind transforming growth factor beta and trigger changes influencing the behaviour of cells. Two types of transforming growth factor receptors have been recognised. They differ in affinity for different members of the transforming growth factor beta family and in cellular mechanisms of action. Transforming growth factor alpha binds to the same receptors as epidermal growth factor (see receptors, epidermal growth factor-urogastrone). (12 Dec 1998) |
| vertical growth phase | Spread of melanoma cells from the epidermis into the dermis and later the subcutis, from which site metastasis may take place. (05 Mar 2000) |
| cell growth | <cell biology> Usually used to mean increase in the size of a population of cells though strictly should be reserved for an increase in cytoplasmic volume of an individual cell. (26 Mar 1998) |
| melanoma growth stimulatory activity | Cytokine of the C X C subfamily. Potent mitogen. Activates and is chemotactic for, neutrophils. (18 Nov 1997) |
| personal growth laboratory | A sensitivity training setting in which the primary emphasis is on each participant's potentialities for creativity, empathy, and leadership. See: sensitivity training group. (05 Mar 2000) |
| chorionic growth hormone-prolactin | human placental lactogen |
| Rubner's laws of growth | The law of constant energy consumption: the rapidity of growth is proportional to the intensity of the metabolic processes, the law of the constant growth quotient: in most young mammals, 24% of the entire food energy, or calories, is utilised for growth; in humans only 5% is utilised. (05 Mar 2000) |
| pituitary growth hormone | <protein> Hormone (191 amino acids) released by anterior pituitary that stimulates release of somatomedin, thereby causing growth. (18 Nov 1997) |
| comb-growth test | A test for androgenic activity, based upon the stimulation of comb growth in capons (castrated cockerels) or immature roosters. Synonym: capon-comb-growth test, cock's comb test. (05 Mar 2000) |
| placental growth hormone | human placental lactogen |
| plant growth regulators | Any of the hormones produced naturally in plants and active in controlling growth and other functions. There are three primary classes: auxins, cytokinins, and gibberellins. (12 Dec 1998) |