| HPG | hvpothalamic-pituitary-gonadal |
|---|---|
| HPG | hypothalamo-pituitary gonadal |
| PS | primitive streak |
| gonadal dysgenesis | <embryology, genetics> A rare genetic disorder in women that is characterised by the absence of an X chromosome. This disorder inhibits normal sexual development and causes infertility. Features include webbing of the neck, short stature, retarded development of secondary sex characteristics, absence of menses, coarctation of the aorta, low hairline, eye abnormalities (drooping eyelids) and skeletal deformities. Treatment include oestrogen supplementation at puberty. Growth hormone replacement may be necessary in some cases. Cardiac surgery may be necessary to correct coarctation of the aorta. Incidence: 1 in 3,000 births. (10 Oct 1997) |
|---|---|
| gonadal dysgenesis, 46,xy | A syndrome characterised by "streak gonads" in a phenotypic female with a 46,xy karyotype. It is due to a mutation which inhibits the function of the y-borne determinant that would normally cause the indifferent embryonic gonad to differentiate into a testis. The streak gonad is incapable of ovulation or oestrogen secretion. The syndrome is sometimes called "pure gonadal dysgenesis," but this designation may also refer to the presence of streak gonads with a 46,xx karyotype. (12 Dec 1998) |
| gonadal dysgenesis, mixed | A syndrome of gonadal dysgenesis in which there is a testis on one side and a "streak gonad" on the other. The phenotype is generally male, but may be female since the individual is a mosaic. Various karyotypes have been identified, including 45,xo/47,xyy; 45,xo/46,xy; and 45,xo/46,xyo. (12 Dec 1998) |
| gonadal hormones | Hormones having oestrogenic (female sex hormones) or androgenic (male sex hormones) activity. (12 Dec 1998) |
| gonadal ridge | An elevation of thickened mesothelium and underlying mesenchyme on the ventromedial border of the embryonic mesonephros; the primordial germ cells become embedded in it, establishing it as the primordium of the testis or ovary. Synonym: genital ridge. (05 Mar 2000) |
| gonadal steroid-binding globulin | A protein that transports 65% of the testosterone in plasma. Synonym: sex steroid-binding globulin. (05 Mar 2000) |
| sex reversal, gonadal | Change from one sex to another with regard to gonadal development; may be induced or occurs naturally in some invertebrates. (12 Dec 1998) |
| neoplasms, gonadal tissue | Neoplasms composed of ovarian or testicular tissue. This concept does not refer to neoplasms located in the ovaries or testes. (12 Dec 1998) |