| cross tolerance | <pharmacology> The resistance to one or several effects of a compound as a result of tolerance developed to a pharmacologically similar compound. (05 Mar 2000) |
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| high dose tolerance | The induction of tolerance by exposure to high doses of antigen. (05 Mar 2000) |
| self tolerance | The normal lack of the ability to produce an immunological response to autologous (self) antigens. A breakdown of self tolerance leads to autoimmune diseases. The ability to recognise the difference between self and non-self is the prime function of the immune system. (12 Dec 1998) |
| species tolerance | The insensitivity to a particular drug exhibited by a particular species. (05 Mar 2000) |
| split tolerance | Modification of an immune response to an antigen after prior exposure to that antigen. Synonym: split tolerance. (05 Mar 2000) |
| nonresponder tolerance | Lack of immune response to antigen. Theories of tolerance induction include clonal deletion and clonal anergy. In clonal deletion, the actual clone of cells is eliminated whereas in clonal anergy the cells are present but nonfunctional. Synonym: immunological tolerance, immunotolerance, nonresponder tolerance. (05 Mar 2000) |
| drug tolerance | Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from drug resistance wherein a human, animal, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. (12 Dec 1998) |
| immune tolerance | The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (foetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc. (12 Dec 1998) |
| immunological tolerance | <immunology> Specific unresponsiveness to antigen. Self tolerance is a process occurring normally early in life due to suppression of self reactive lymphocyte clones. Tolerance to foreign antigens can be induced in adult life by exposure to antigens under conditions in which specific clones are suppressed. Note that tolerance is not the same as immunological unresponsiveness, since the latter may be very non-specific as in immunodeficiency states. (18 Nov 1997) |
| immunologic high dose tolerance | Induction of tolerance by exposure to large amounts of protein antigens. (05 Mar 2000) |
| immunologic tolerance | Lack of immune response to antigen. Theories of tolerance induction include clonal deletion and clonal anergy. In clonal deletion, the actual clone of cells is eliminated whereas in clonal anergy the cells are present but nonfunctional. Synonym: immunological tolerance, immunotolerance, nonresponder tolerance. (05 Mar 2000) |
| individual tolerance | Tolerance to a drug that the person has never received before. (05 Mar 2000) |
| tolerance | 1. The ability to endure unusually large doses of a drug or toxin. 2. Acquired drug tolerance, a decreasing response to repeated constant doses of a drug or the need for increasing doses to maintain a constant response. Origin: L. Tolerantia (18 Nov 1997) |
| tolerance dose | The largest dose of a remedy that can be accepted without the production of injurious symptoms. (05 Mar 2000) |
| exercise tolerance | The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an exercise test. (12 Dec 1998) |