| MLC | 1) Minimal Lethal Concentration 2) Mixed Lymphocyte Culture |
|---|---|
| PLD | POtentially Lethal Damage |
| SLD | Sub-Lethal Damage |
| CELO | chick embryonal lethal orphan [virus] |
| DL | danger list; De Lee [catheter]; deep lobe; developmental level; difference limen; diffusion lung [ca... |
| lethal dwarfism | Dwarfism leading to intrauterine or neonatal death. (05 Mar 2000) |
|---|---|
| lethal equivalent | A combination of selective effects that on average have the same impact on the composition of the gene pool as one death; e.g., two carriers at 50% risk of dying would be the lethal equivalent of one carrier at 100% risk, in the population genetics of recessive traits lethal equivalent is expressed as twice the sum of the expected number of deaths ascribable to the genetic load. Expression used of the genetic load of recessive genes in heterozygous state that if in homozygous state would cause death or carry a risk of death. The expected number of deaths from all such genes is expressed in lethal equivalent. (05 Mar 2000) |
| lethal factor | A disorder that prevents effective reproduction by those affected; e.g., Klinefelter syndrome. (05 Mar 2000) |
| lethal gene | A gene that produces a genotype that leads to death of the organism before reproduction is possible or that precludes reproduction; for a recessive gene the homozygous or hemizygous state is lethal. (05 Mar 2000) |
| lethal midline granuloma | Destruction of the nasal septum, hard palate, lateral nasal walls, paranasal sinuses, skin of the face, orbit and nasopharynx by an inflammatory infiltrate with atypical lymphocytic and histiocytic cells; presumably a form of lymphoma in most cases. An obsolete term for polymorphic reticulosis. Synonym: granuloma gangrenescens, malignant granuloma, midline malignant reticulosis granuloma. (05 Mar 2000) |
| lethal mutation | <genetics, molecular biology> Mutation that eventually results in the death of an organism carrying the mutation. (18 Nov 1997) |
| breast cancer susceptibility genes | Inherited factors that predispose to breast cancer. Put otherwise, these genes make one more susceptible to the disease and so increase the risk of developing breast cancer. Two of these genes, BRCA1 and BRCA2, have been identified (and prominently publicised). Several other genes (those for the Li-Fraumeni syndrome, Cowden disease, Muir-Torre syndrome, and ataxia-telangiectasia) are also known to predispose to breast cancer. However, since all of these known breast cancer susceptibility genes together do not account for more than a minor fraction (1/5th at most) of breast cancer that clusters in families, it is clear that more breast cancer genes remain to be discovered. (12 Dec 1998) |
| cancer, breast, susceptibility genes | Inherited factors that predispose to breast cancer. Put otherwise, these genes make one more susceptible to the disease and so increase the risk of developing breast cancer. Two of these genes, BRCA1 and BRCA2, have been identified (and prominently publicised). Several other genes (those for the Li-Fraumeni syndrome, Cowden disease, Muir-Torre syndrome, and ataxia-telangiectasia) are also known to predispose to breast cancer. However, since all of these known breast cancer susceptibility genes together do not account for more than a minor fraction (1/5th at most) of breast cancer that clusters in families, it is clear that more breast cancer genes remain to be discovered. (12 Dec 1998) |
| genes | Located in the nucleus of the cell, genes contain hereditary information that is transferred from cell to cell. (09 Oct 1997) |
| genes, abl | Retrovirus-associated DNA sequences (abl) originally isolated from the abelson murine leukaemia virus (ab-mulv). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukaemia. (12 Dec 1998) |
| genes, apc | Tumour suppressor genes located in the 5q21 region on the long arm of chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (apc stands for adenomatous polyposis coli) and gardner's syndrome, as well as some sporadic colourectal cancers. (12 Dec 1998) |
| genes, arac | Regulatory genes which encode a cyclic AMP receptor protein required for l-arabinose utilization in e. Coli. It is an example of positive control or regulation of gene expression in the bacterial operon. (12 Dec 1998) |
| genes, archaeal | The genetic material of archaea. (12 Dec 1998) |
| genes, bacterial | The genetic material of bacteria. (12 Dec 1998) |
| genes, bcl-1 | The B-cell leukaemia/lymphoma-1 genes, associated with various neoplasms when overexpressed. Overexpression results from the t(11;14) translocation, which is characteristic of mantle zone-derived B-cell lymphomas. The human c-bcl-1 gene is located at 11q13 on the long arm of chromosome 18. (12 Dec 1998) |