| MAP kinase kinase kinase | <enzyme> From pc12 cells; reactivates map kinase kinase inactivated by protein phosphatase 2a by phosphorylation of serine residues; tak1 (tgf-beta-activated kinase 1) is a member of the mapkkk family; genbank ab006787 (mouse) Registry number: EC 2.7.10.- Synonym: mapkkk, tak1 mapkkk, ask1 (kinase), apoptosis signal-regulating kinase 1 (26 Jun 1999) |
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| map, linkage | A map of the genes on a chromosome based on linkage analysis. A linkage map does not show the physical distances between genes but rather their relative positions, as determined by how often two gene loci are inherited together. The closer two genes are (the more tightly they are linked), the more often they will be inherited together. Linkage distance is measured in centimorgans (cm). (12 Dec 1998) |
| map, physical | A map of the locations of identifiable landmarks on chromosomes. Physical distance is measured in base pairs. The physical map differs from the genetic map which is based purely on genetic linkage data. In the human genome, the lowest-resolution physical map is the banding patterns of the 24 different chromosomes. The highest-resolution physical map is the complete nucleotide sequence of all chromosomes, a future goal. (12 Dec 1998) |
| genetic map | <genetics> A map of the relative positions of genetic loci on a chromosome, determined onthe basis of how often the loci are inherited together. Distance ismeasured in centimorgans (cM). (09 Oct 1997) |
| restriction map | <molecular biology> Map of DNA showing the position of sites recognised and cut by various restriction endonucleases. (12 Jan 1998) |
| peptide map | Proteases will produce fragments of a characteristic size from a protein and this can be used as a test for the identity or otherwise of two similar sized proteins. It is possible to produce a peptide fragment map from a single gel band. (18 Nov 1997) |
| chromosomal map | A formal, stylised representation of the karyotype and of the positioning and ordering on it of those loci that have been localised by any of several mapping methods. (05 Mar 2000) |
| chromosome map | The chart of the linear array of genes on a chromosome. The Human Genome Project aims to map all of the human chromosomes. (12 Dec 1998) |
| physical map | <molecular biology> A map of the locations of identifiable landmarks on DNA (for example, restriction enzyme cutting site, genes), regardless of inheritance. Distance is measured in base pairs. For the human genome, the lowest-resolution physical map is the banding patterns on the 24 different chromosomes, the highest-resolution map wouldbe the complete nucleotide sequence of the chromosomes. (09 Oct 1997) |
| conformational map | A graphical representation in which the dihedral angle of rotation about the alpha-carbon to carbonyl-carbon bond in polypeptides is plotted against the dihedral angle of rotation about the alpha-carbon to nitrogen bond. Synonym: conformational map. (05 Mar 2000) |
| contig map | <molecular biology> A map depicting the relative order of a linked library of small overlapping clones representing a complete chromosomal segment. (10 Nov 1998) |
| contiguous map | <molecular biology> A map depicting the relative order of a linked library of small overlapping clones representing a complete chromosomal segment. (10 Nov 1998) |
| cosmid map | <molecular biology> A physical map that includes a collection of bacteria containing cosmids that carry the DNA fragments under study. (10 Nov 1998) |
| cytogenetic map | A map in which the classical bonding pattern of a chromosome is shown. (05 Mar 2000) |
| sequence-tagged site map | A map representing the order and spacing of sequence-tagged sites within a stretch of DNA. (05 Mar 2000) |