| 영문 | epidemic hemorrhagic fever | 한글 | 유행출혈열 |
|---|---|---|---|
| 설명 | 한국전쟁당시 국내에서 발견되면서 한때 한국형 출혈열(Korean hemorrhagic fever)이라고도 불리웠던 이 병은 갑자기 시작하는 오한, 두통, 근육통을 나타내고 이어서 3~5일 내에 전신 피부 및 공막출혈, 혈소판감소증, 단백뇨 및 신장 기능상실 등이 온다. 말기에는 쇼크 및 저체온이 될 수 있다. 처음 7~10일 간에 살아남은 환자들은 서서히 회복되나 단백뇨의 핍뇨는 수 주간 지속된다. 증세에 따라서 발열기, 저혈압기, 감뇨기, 이뇨기, 회복기로 비교적 특이하게 구분된다. Hantaan virus라고 불리는 이 병원체는 세포질에서 자라는 RNA 바이러스이며 Bunyaviridae과에 속하는 Hanta 바이러스속에 속하는 종(species)으로 한탄 바이러스 이외에 Puumula virus, Hill virus가 있다. 최근에 환자로부터 한탄바이러스와는 구분되는 Seoul virus가 분리, 동정됨에 따라서 야외형(Hantaan virus)과 도시형(Seoul virus)이 병원체가 서로 다르다는 점이 알려졌다. 한국을 비롯하여 만주, 시베리아 등지에서 유행하는 질환으로 알려졌으나 한탄바이러스의 발견을 계기로 혈청검사가 가능해지자 한탄바이러스 내지는 이와 항원구조가 유사한 바이러스로 생기는 감염증이 세계 각처에 분포되어 있다는 것이 판명되었다. 계절적인 발생은 특이하며, 국내에서는 봄과 가을에 두 번의 유행이 있다고 하지만 최근에는 가을의 유행이 크다. 특징적인 육안적 소견은 콩팥속질의 출혈, 오른심방출혈, 뇌하수체 전엽의 괴사이며, 이밖에 후복강 연조직의 심한 부종, 체강내로 누출된 체액 저류, 장막의 산재성 출혈, 돌창자의 점막출혈, 폐부종 내지는 폐출혈 등이다. 조직소견의 특징은 여러 장기의 출혈과 콩팥속질, 뇌하수체, 부신 등에 생기는 초점성 응고성 괴사와 각 장기의 광범성 단핵세포 침윤이며, 세정맥이 확장되고 울혈이 생기고 혈장과 적혈구가 혈관외로 누출되고 부위에 따라서는 초점성 모세혈관 파열이 나타나 있다. |
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| newborn screening | Tests of newborns to detect those at increased risk for disorders such as pku (phenylketonuria) and hypothyroidism. (12 Dec 1998) |
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| subcutaneous fat necrosis of newborn | Indurated plaques and nodules appearing usually a few days or a few weeks after birth and usually resolving within a few months, characterised microscopically by birefringent needle-shaped crystals within necrotic fat cells; the condition remains localised, unlike sclerema neonatorum. (05 Mar 2000) |
| disease, haemolytic, of the newborn | Abnormal breakup of red blood cells in the foetus or newborn. (12 Dec 1998) |
| infant, newborn | An infant during the first month after birth. (12 Dec 1998) |
| infant, newborn, diseases | Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both hereditary diseases and metabolism, inborn errors are available as general concepts. (12 Dec 1998) |
| jaundice of the newborn | Icterus which can be accentuated by many factors including excessive haemolysis, sepsis, neonatal hepatitis or congenital atresia of the biliary system. Synonym: physiologic icterus, jaundice of the newborn, neonatal jaundice, physiologic jaundice. (05 Mar 2000) |
| leukocytosis of the newborn | An apparently "physiologic" leukocytosis usually observed in newborn infants, in whom the white blood cell counts are usually greater than 10,000 per cu mm, and sometimes range to 45,000 per cu mm, resulting chiefly from increased numbers of neutrophils (especially single and bilobed forms). On the third or fourth day of life, the count generally decreases rapidly, and then fluctuates for several days; beginning about the fourth week of life, a relative lymphocytosis is observed, and this normally continues for a few years. (05 Mar 2000) |
| acute epidemic conjunctivitis | An obsolete term for an acute conjunctivitis marked by intense hyperaemia and profuse mucopurulent discharge. Synonym: acute epidemic conjunctivitis, pinkeye. (05 Mar 2000) |
| acute epidemic leukoencephalitis | A disease characterised by acute onset of fever, followed by convulsions, delirium, and coma, and associated with perivascular demyelination and haemorrhagic foci in the central nervous system. Synonym: acute primary haemorrhagic meningoencephalitis, Strumpell's disease. (05 Mar 2000) |
| behavioural epidemic | An epidemic originating in behavioural patterns (in contrast to invading microorganisms); examples include medieval dancing mania, episodes of crowd panic. (05 Mar 2000) |
| person to person epidemic | An epidemic resulting from person to person contact, characterised by a gradual rise and fall in number of cases. (09 Oct 1997) |
| common-source epidemic | <microbiology> An epidemic resulting from infection of a large number of people from a single contaminated source. (09 Oct 1997) |
| pleurodynia, epidemic | An acute, febrile, infectious disease generally occurring in epidemics, most often seen in persons under the age of 20. It is usually caused by coxsackie viruses b and sometimes by coxsackie viruses a, echoviruses, and other enteroviruses. (12 Dec 1998) |
| point epidemic | An epidemic where a pronounced clustering of cases of disease occurs within a very short period of time (within a few days or even hours) due to exposure of persons or animals to a common source of infection such as food or water. (05 Mar 2000) |
| porcine epidemic diarrhoea | A disease of pigs caused by the porcine epidemic diarrhoea virus and characterised by acute diarrhoea, with high mortality in piglets. (05 Mar 2000) |