| ECFC | eosinophilic chemotactic factor complement |
|---|---|
| ECI | electrocerebral inactivity; eosinophilic cytoplasmic inclusions; extracorporeal irradiation |
| EF | ectopic focus; edema factor; ejection fraction; elastic fibril; electric field; elongation factor; e... |
| EG | enteroglucagon; eosinophilic granuloma; esophagogastrectomy; ethylene glycol; external genitalia |
| EGL | eosinophilic granuloma of the lung |
| eosinophilic meningitis | Infection of animals and man with nematodes of the genus Angiostrongylus. Synonym: eosinophilic meningitis. (05 Mar 2000) |
|---|---|
| eosinophilic meningoencephalitis | A disease caused by infection with the rat lungworm, Angiostrongylus cantonensis, whose larvae, ingested with infected slugs or land snails (or some unidentified transport host), migrate from intestine to the meninges of the brain where the disease is produced; it is usually mild, of short duration, and characterised by fever, eosinophilia, and white blood cells (rarely nematode larvae) in the spinal fluid. (05 Mar 2000) |
| eosinophilic pneumonia | A self-limiting inflammation in the lungs where there is associated infiltration of eosinophils into lung tissue. Chest X-ray reveals pulmonary infiltrates and full blood count (CBC) shows increased numbers of eosinophils. The cause is unknown and the disease often resolves without treatment. Some forms may be treated with oral corticosteroids. Complications include restrictive cardiomyopathy due to fibrosis of the lining of the heart. (27 Sep 1997) |
| eosinophilic pneumonopathy | A self-limiting inflammation in the lungs where there is associated infiltration of eosinophils into lung tissue. Chest X-ray reveals pulmonary infiltrates and full blood count (CBC) shows increased numbers of eosinophils. The cause is unknown and the disease often resolves without treatment. Some forms may be treated with oral corticosteroids. Complications include restrictive cardiomyopathy due to fibrosis of the lining of the heart. (27 Sep 1997) |
| eosinophilic pustular folliculitis | A dermatosis characterised by sterile pruritic papules and pustules that coalesce to form plaques with papulovesicular borders; spontaneous exacerbations and remissions may be accompanied by peripheral leukocytosis, eosinophilia, or both, and may result in eventual destruction of hair follicles and formation of eosinophilic abscesses. The disease has been reported in AIDS, and a possibly separate form of eosinophilic pustular folliculitis occurs in infants. Synonym: Ofuji's disease. (05 Mar 2000) |
| fasciitis, eosinophilic | A disease which leads to inflammation and thickening of the skin and fascia. (The fascia is a lining tissue under the skin that covers a surface of underlying tissues. When the fascia is inflamed, the condition is referred to as fasciitis. ) In eosinophilic fasciitis, the involved fascia is inflamed with the eosinophil white blood cells. There is progressive thickening, and often redness and warmth, and hardness of the skin surface. (12 Dec 1998) |
| abelson leukaemia virus | A defective murine leukaemia virus capable of transforming lymphoid cells and producing a rapidly progressing lymphoid leukaemia after superinfection with friend, moloney, or rauscher virus. (12 Dec 1998) |
| Abelson murine leukaemia virus | A retrovirus belonging to the Type C retrovirus group subfamily (family Oncovirinae) which is associated with leukaemia and produces in vitro transformation of mouse cells. (05 Mar 2000) |
| accelerated phase of leukaemia | Refers to chronic myelogenous leukaemia that is progressing. The number of immature, abnormal white blood cells in the bone marrow and blood is higher than in the chronic phase, but not as high as in the blast phase. (12 Dec 1998) |
| acute granulocytic leukaemia | <haematology> A form of leukaemia which is characterised by the proliferation of immature white blood cells (granulocytes) in the bloodstream. Occurs primarily in adults and in infants under 1 year of age. Complications include abnormal bleeding and susceptibility to infections. Symptoms include fatigue, weight loss, fevers, weakness, pallor, bone pains, bleeding gums, nosebleeds, easy bruising, enlarged lymph nodes and joint pains. Treatment includes chemotherapy and/or bone marrow transplant. Origin: Gr. Haima = blood (27 Sep 1997) |
| acute leukaemia | <haematology> A rapidly progressive cancer of the blood of sudden onset and characterised by the uncontrolled proliferation of immature blood cells which take over the bone marrow and spill into the blood stream. If left untreated is fatal within a few weeks or months. See: acute lymphoblastic leukaemia, acute myeloid leukaemia. Origin: Gr. Haima = blood (11 Nov 1997) |
| acute lymphoblastic leukaemia | <haematology> A rapidly progressing cancer of the blood affecting the type of white blood cell known as lymphocytes. Approximately 650 new cases are diagnosed every year in the UK and it is the most common form of childhood leukaemia. Acronym: ALL Origin: Gr. Haima = blood (11 Nov 1997) |
| acute lymphocytic leukaemia | <radiology> 95% of cases of leukaemia in children, bone changes in 50-70% of kids (vs. 10% in adults); seen as early as 1 month after onset of symptoms, wrists and knees most commonly affected, bony defects: metaphyseal radiolucent bands! (similar findings in scurvy, JRA, syphilis), osteolytic lesions, periosteal reaction, osteosclerosis (12 Dec 1998) |
| acute monocytic leukaemia | <haematology> The most common translocation in this disorder of poorly differentiated monocytic cells involves chromosome region 11q in a large percentage of cases. The translocation involves a cellular oncogene, c-ets which is mapped to the 11q23-24 region. The most common translocations reported are t(6;11), t(9;11), t(11;17) and t(11;19), of which t(9;11) (p21-22;q23) is by far the most frequently detected and implicated in acute myeloid leukaemia. The cells express CD14 surface antigen, which is diagnostic of monocytic cells. Acronym: AML Classification: FAB M5 (07 Apr 1998) |
| acute myeloblastic leukaemia | <haematology> A rapidly progressing cancer of the blood affecting immature cells of the bone marrow, usually of the white cell population. It is much more common in adults than in children. Symptoms include fatigue, weight loss, fevers, weakness, pallor, bone pains, bleeding gums, nosebleeds, easy bruising, enlarged lymph nodes and joint pains. Treatment includes chemotherapy and/or bone marrow transplant. This leukaemia demonstrates granulocyte differentiation, eosinophilia and Auer rods and is associated with a reciprocal translocation between 8 and 21 (q22;q22), which is the most common translocation in acute myeloid leukaemia and is found more often in younger patients than in older patients. The oncogene involved in this translocation is AML1, which can be detected by Southern blot. Numerical abnormalities, particularly monosomy-7, trisomy-4, trisomy-8, trisomy-21, -Y, monosomy-7 and deletions of the long arms of chromosomes 5 and 7 are quite common in all acute myeloid leukaemia and not restricted to any one FAB classification. Many of these abnormalities are observed at diagnosis and at later stage disease, particularly after chemotherapy. Prognosis is generally more favorable than in FAB-M2 patients showing no translocation, because the latter patients show better remission rates for longer periods of time. Immunophenotyping is useful in diagnosis and expression of one or more of the myeloid antigens CD13, CD14 or CD33 must be detected to make a diagnosis of acute myeloid leukaemia. Acronym: AML Incidence: 2,000 new cases per year in the UK. Origin: Gr. Haima = blood (07 Apr 1998) |