| 영문 | antianginal drug | 한글 | 항협심증제 |
|---|---|---|---|
| 설명 | 협심증은 심장동맥의 혈류를 좋게하거나 심장이 혈류에 비해서 많은 일을 하는 것을 억제함으로써 치료될 수 있다. ① nitrate계통의 약물: 혈관을 이완시키는 작용을 함으로써 심장동맥의 혈류를 좋게 한다. ② 칼슘통로차단제(verapamil, nifedipine): 모든 근육의 수축에는 Ca이 관여한다. 즉 Ca이 있어야만 근육의 수축이 가능해진다. 그러므로 Ca이 세포속으로 들어가는 것을 억제하는 약제는 근육의 수축을 막는다. 이 약은 심장의 근육에 작용하여 심장 근육의 수축을 억제하며 심장이 과도하게 일하는 것을 막고, 또 심장동맥의 수축에 관여하는 근육에 작용을 하여 심장동맥을 이완시켜서 혈류를 좋게 한다. ③ 베타차단제(beta-blocker): 신체의 운동량이나 기타의 요구에 의해서 심장을 빨리 뛰게하는 신경은 바로 베타-교감신경이다. 교감신경계란 사람이 위급한 상황에서 작용하는 자율신경계이다. 즉 사람이 긴장하거나 싸울 경우에 전형적으로 교감신경계가 작용한다. 즉 심장이 뛰거나 소화가 않되거나 동공이 커지는 것 따위가 바로 교감신경계의 역할이라고 할 수 있다. 이 교감신경계에서 말초장기에 보내는 신경이 교감신경이다. 그러므로 심장에서 심장을 신체에 필요에 따라서 많은 일을 하게하는 신경을 차단할 경우에는 협심증을 치료할 수 있게 된다(심장의 산소나 기타 영양분의 수요를 줄인다). |
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| DD | dangerous drug; data definition; day of delivery; degenerated disc; degenerative disease; delusional... |
|---|---|
| DI | date of injury; defective interfering [particle]; dentinogenesis imperfecta; deoxyribonucleic acid i... |
| DUR | drug use review; drug utilization review |
| IVDA/IVDU | intravenous drug abuse/ abuser; intravenous drug use/user |
| Rx | drug; medication; pharmacy; prescribe, prescription, prescription drug; take [Lat. recipe]; therapy;... |
| human clinical trial | <pharmacology> Controlled clinical studies in human volunteers to test the safety and efficacy of pharmaceutical candidates. There are usually three distinct phases of human clinical testing: Phases I, II, and III. Phase I trials are safety studies of volunteers, usually healthy controls. Phase II trials are studies to confirm safety and study optimum dose and initial efficacy. Phase III trials are studies to prove safety and efficacy in a specific patient population. (14 Nov 1997) |
|---|---|
| open-label trial | A study in which both researchers and participants know what drug a person is taking and at what dose. (09 Oct 1997) |
| trial | 1. The act of trying or testing in any manner. Specifically: Any effort or exertion of strength for the purpose of ascertaining what can be done or effected. "[I] defy thee to the trial of mortal fight." (Milton) The act of testing by experience; proof; test. "Repeated trials of the issues and events of actions." (Bp. Wilkins) Examination by a test; experiment, as in chemistry, metallurgy, etc. 2. The state of being tried or tempted; exposure to suffering that tests strength, patience, faith, or the like; affliction or temptation that exercises and proves the graces or virtues of men. "Others had trial of cruel mockings and scourgings." (Heb. Xi. 36) 3. That which tries or afflicts; that which harasses; that which tries the character or principles; that which tempts to evil; as, his child's conduct was a sore trial. "Every station is exposed to some trials." (Rogers) 4. The formal examination of the matter in issue in a cause before a competent tribunal; the mode of determining a question of fact in a court of law; the examination, in legal form, of the facts in issue in a cause pending before a competent tribunal, for the purpose of determining such issue. Synonym: Test, attempt, endeavor, effort, experiment, proof, essay. See Test, and Attempt. Origin: From Try. Source: Websters Dictionary (01 Mar 1998) |
| trial and error | The apparently random, haphazard, hit-or-miss exploratory activity which often precedes the acquisition of new information or adjustments; it may be overt, as in a rat running in a maze, or covert (vicarious), as when one thinks of various ways of coping with a situation. (05 Mar 2000) |
| trial base | <cell biology> A hypothetical cell adhesion molecule possibly involved in sponge cell adhesion, existence unproven. (18 Nov 1997) |
| trial case | In refraction, a box containing lenses for testing. (05 Mar 2000) |
| trial denture | A setup of artificial teeth so fabricated that it may be placed in the patient's mouth to verify esthetics, for the making of records, or for any other operation deemed necessary before final completion of the denture. Synonym: wax model denture. (05 Mar 2000) |
| trial frame | A type of spectacle frame with variable adjustments, for holding trial lenses during refraction. (05 Mar 2000) |
| trial lenses | A series of cylindrical and spherical lens's used in testing vision. (05 Mar 2000) |
| trial of labour | Allowing a woman to be in labour long enough to determine if vaginal birth may be anticipated. (12 Dec 1998) |
| abnormalities, drug-induced | Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment. (12 Dec 1998) |
| activity, drug | A measure of the physiological response a drug produces in the body. A less active drug produces less response (and visa versa). (12 Dec 1998) |
| addictive drug | Any drug that creates a certain degree of euphoria and has a strong potential for addiction. (05 Mar 2000) |
| adverse drug reaction reporting systems | Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions. (12 Dec 1998) |
| akathisia, drug-induced | Motor restlessness with sensations of quivering and an urge to move about constantly resulting from the use of certain drugs, such as neuroleptic drugs, which affect the extrapyramidal region of the brain. This differs from dyskinesia, drug-induced in that long-term antipsychotic drug exposure is significantly correlated with the increased prevalence of akathisia while there is no such correlation with dyskinesia. The primary observable distinction between tardive akathisia and dyskinesia appears to be in the repetitive, stereotypy of the dyskinesic movements (lip smacking, for example), while akathisia is associated with anxiety, restlessness, and agitation (psychomotor agitation). (12 Dec 1998) |