| disseminated cutaneous leishmaniasis | Leishmaniasis caused by several New and Old World species and strains of Leishmania (L. Mexicana amazonensis, L. M. Pifanoi, possibly L. M. Garnhami and L. M. Venezuelensis; in Ethiopia, L. Aethiopica, and unidentified leishmanial agents in Namibia and Tanzania). The condition is associated with a suppressed cell-mediated immune response, so that the non-ulcerating, non-necrotizing cutaneous lesions can spread widely over the body; great numbers of parasite-filled macrophages are found in the dermal lesions. Healing does not appear to occur unless an acquired cellular hypersensitivity can develop. Synonym: anergic leishmaniasis, diffuse leishmaniasis, disseminated cutaneous leishmaniasis, leishmaniasis tegumentaria diffusa, pseudolepromatous leishmaniasis. (05 Mar 2000) |
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| disseminated disease | Disease in which the cancerous cells have spread from the tissue of origin to other organs. (13 Nov 1997) |
| disseminated gonococcal infection | Infection from Neisseria gonorrhoea which is spread to distant parts of the body beyond the original portal of entry (usually the lower genital tract). Usually manifest by rash and arthritis. (05 Mar 2000) |
| disseminated intravascular coagulation | <haematology> Complication of septic shock in which endotoxin (from gram-negative bacteria) induces systemic clotting of the blood, probably indirectly through the effect of endotoxin on neutrophils. It may also develop in other situations where neutrophils become systemically hyperactivated. Acronym: DIC (11 Jan 1998) |
| disseminated lupus erythematosus | <immunology, nephrology, rheumatology> A disease of humans, probably autoimmune with antinuclear and other antibodies in plasma. Immune complex deposition in the glomerular capillaries is a particular problem. Acronym: SLE (19 Jan 1998) |
| disseminated necrotizing leukoencephalopathy | <radiology> DNL: demyelination due to radiation and chemotherapy, decreased density in deep white matter, with or without peripheral, patchy enhancement, calcification: basal ganglia, grey/white junction (12 Dec 1998) |
| disseminated sclerosis | <neurology> Neurodegenerative disease characterised by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in 3rd or 4th decade with intermittent progression over an extended period. Cause still uncertain. (18 Nov 1997) |
| disseminated tuberculosis | <microbiology> Usually a chronic tuberculosis infection where spread of the original primary infection has occurred via the patients lymphatic system (or bloodstream). Disseminated disease occurs primarily in the immunocompromised individual (for example AIDS, cancer patient). The elderly are at increased risk for dissemination. In disseminated disease, organs and tissues that can be affected include pericardium, peritoneum, larynx, bronchus, bone, joints, lymph nodes, stomach, meninges, eyes, kidneys and skin. Treatment is with INH, rifampin, ethambutol and other antibiotics. (11 Jan 1998) |
| encephalomyelitis, acute disseminated | An acute or subacute encephalomyelitis or myelitis characterised by perivascular lymphocyte and mononuclear cell infiltration and demyelination. It occurs most commonly following an acute viral infection, especially measles, but may occur without a recognizable antecedent, and formerly occurred as a complication of rabies and smallpox vaccination. (12 Dec 1998) |
| acne simplex | <dermatology> A form of acne which results from the bacterial infection of cysts deep within the skin. Generally requires treatment with antibiotics and other agents (Isotretinoin). Without treatment cystic acne may result in scarring. (27 Sep 1997) |
| adiposis tuberosa simplex | A condition resembling adiposis dolorosa, in which the fat occurs in small, nodular masses, which are sensitive to touch and may be spontaneously painful, on the abdomen or on the extremities. (05 Mar 2000) |
| articulatio simplex | One composed of two bones only. Synonym: articulatio simplex. (05 Mar 2000) |
| carcinoma simplex | An obsolete term for any form of carcinoma in which the relative proportions of stroma and neoplastic epithelial cells are not unusual, i.e., stromal elements are not comparatively abundant, nor are they reduced in amount or lacking; an obsolete term for a carcinoma lacking any identifiable microscopic pattern, such as glandular structure. (05 Mar 2000) |
| verruca simplex | A keratotic papilloma of the epidermis which occurs most frequently in young persons as a result of localised infection by human papilloma virus, usually types 2 and 4; the lesions are of variable duration, eventually undergoing spontaneous regression, and are both exophytic and endophytic, with hyperkeratosis, parakeratosis, hypergranulosis, koilocytosis, and papillomatosis. Synonym: common wart, infectious warts, verruca simplex, viral wart. (05 Mar 2000) |
| periodontitis simplex | Horizontal resorption of the alveolar process with pockets of even depth on adjacent teeth; traumatic occlusion is not a factor. (05 Mar 2000) |