| dihydroergocristine | An ergot alkaloid derivative prepared by the hydrogenation of ergocristine and less toxic than the latter. See: dihydroergotoxine mesylate. (05 Mar 2000) |
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| dihydroergocryptine | An ergot alkaloid derivative prepared by the hydrogenation of ergocryptine and less toxic than the latter. See: dihydroergotoxine mesylate. (05 Mar 2000) |
| dihydroergotamine | <chemical> 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione. A derivative of ergotamine prepared by the catalytic hydrogenation of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine. Pharmacological action: analgesics, non-narcotic, vasoconstrictor agents. Chemical name: Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha,10alpha)- (12 Dec 1998) |
| dihydroergotoxine | <chemical> Dihydroergotoxine. A mixture of three different ergotaman-3',6',18-triones, dihydroergocornine, dihydroergocristine, and dihydroergocryptine. It has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. The combination of the methanesulfonate salts of these alkaloids is dihydroergotoxine mesylate (see ergoloid mesylates). Pharmacological action: adrenergic alpha-antagonists, dopamine agonists, neuroprotective agents, nootropic agents. Chemical name: Ergotoxine, dihydro- (12 Dec 1998) |
| dihydroergotoxine mesylate | A mixture of dihydroergocornine methanesulfate, dihydroergocristine methanesulfate, and dihydroergocryptine methane sulfate; used as an alpha-adrenergic blocking agent for relief of cardiovascular insufficiency. (05 Mar 2000) |
| dihydroflavanol 4-reductase | <enzyme> Isolated from flowers of dahlia varibilis; requires NADPH as a cofactor; catalyses the transfer of pro-s hydrogen of NADPH to the substrate; pH optima 6.0 for flavanones and 6.8 for dihydroflavonols Registry number: EC 1.1.1.- Synonym: 3-hydroxyflavanone 4-reductase, dhf reductase, dihydroflavonol-4-reductase, dihydroflavanol reductase (26 Jun 1999) |
| dihydrofolate monooxygenase | <enzyme> 7,8-dihydrofolate plus 1/2 o2 gives 7,8-dihydropterin-6-aldehyde plus p-aminobenzoylglutamate Registry number: EC 1.13.- (26 Jun 1999) |
| dihydrofolate reductase | <enzyme> An enzyme involved in the biosynthesis of folic acid coenzymes, that transfers hydrogen from NADP to dihydrofolate, yielding tetrahydrofolic acid. Inhibitors can be used as antimicrobial and anticancer drugs. Standard source is liver and the enzyme is used to assay dihydrofolate. (18 Nov 1997) |
| dihydrogen phosphate | One-third-neutralised phosphoric acid; e.g., NaH2PO4, KH2PO4. Disodium phosphate, na2HPO4. (05 Mar 2000) |
| dihydrogeodin oxidase | <enzyme> Copper-containing enzyme which converts dihydrogeodin to (+)-geodin by an intramolecular phenol oxidative coupling reaction; isolated from aspergillus terreus Registry number: EC 1.10.3.- (26 Jun 1999) |
| dihydrolipoamide acetyltransferase | <enzyme> Part of the pyruvate dehydrogenase complex; acef isolated from e. Coli Registry number: EC 2.3.1.12 Synonym: dihydrolipoyl transacetylase, lipoate acetyltransferase, dihydrolipoyl acetyltransferase, acef gene product (26 Jun 1999) |
| dihydrolipoamide acyltransferase | <enzyme> Component of branched-chain 2-oxo acid dehydrogenase multienzyme complex; mutation in this (e2) catalytic subunit identifies type II maple syrup urine disease Registry number: EC 2.3.1.- Synonym: dihydrolipoyl transacylase, branched chain acyltransferase, e2 transacylase (26 Jun 1999) |
| dihydrolipoamide dehydrogenase | <enzyme> An enzyme oxidizing dihydrolipoamide at the expense of NAD+; completes the oxidative decarboxylation of pyruvate; a part of several enzyme complexes (e.g., alpha-ketoglutarate dehydrogenase complex). Decreased activity leads to neuronal loss in brain resulting in psychomotor retardation. Synonym: coenzyme factor, lipoamide dehydrogenase, lipoamide reductase (NADH), lipoyl dehydrogenase. (05 Mar 2000) |
| dihydrolipoamide succinyltransferase | <enzyme> Component of the ketoglutarate dehydrogenase complex Registry number: EC 2.3.1.61 Synonym: succinyl-CoA-dihydrolipoate-s-succinyltransferase, dihydrolipoyl transsuccinylase, lipoyl transsuccinylase, lipoate succinyltransferase, lipoamide succinyltransferase, succinyl-coenzyme a-dihydrolipoate-s-succinyltransferase (26 Jun 1999) |
| dihydrolipoic acid | Reduced lipoic acid, formed by cleavage of the -S-S- bond as a result of the acceptance of two hydrogens. Compare: lipoic acid. (05 Mar 2000) |