| analgesia, patient-controlled | Relief of pain, without loss of consciousness, through an analgesic agent administered by the patient. It has been used successfully to control postoperative pain, during labour, after burns, and in terminal care. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimised by combining small bolus doses with a mandatory interval between successive doses (lockout interval). (12 Dec 1998) |
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| randomised controlled trial | A clinical trial that involves at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table. Treatment allocations using coin flips, odd-even numbers, patient social security numbers, days of the week, medical record numbers, or other such pseudo- or quasi-random processes, are not truly randomised and a trial employing any of these techniques for patient assignment is designated simply a controlled clinical trial. (12 Dec 1998) |
| randomised controlled trials | Clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table. Treatment allocations using coin flips, odd-even numbers, patient social security numbers, days of the week, medical record numbers, or other such pseudo- or quasi-random processes, are not truly randomised and trials employing any of these techniques for patient assignment are designated simply controlled clinical trials. (12 Dec 1998) |
| patient controlled analgesia | <anaesthetics, procedure> Self-administration of analgesics by a patient instructed in doing so, usually refers to self-dosing with intravenous opioid (for example, morphine) administered by means of a programmable pump. (16 Dec 1997) |
| vocabulary, controlled | A means of access to information (including bibliographic records, factual data, images, collections, etc.) limited to a specified list of terms with a fixed and unalterable meaning, and from which a selection is made when cataloging, indexing, or searching books, journals, and other documents. The control is intended to avoid the scattering of related subjects under different headings. The list may be altered or extended only by the publisher or issuing agency. (12 Dec 1998) |
| research, controlled | The first controlled clinical research was probably done in 1875 by the british naval surgeon james lind who, on board the hms salisbury, gave sailors with scurvy either oranges or lemons or cider or vinegar or nutmeg (or another treatment) and after just six days discovered that the citrus-consuming sailors had recovered from scury, until then the scourge of extended sea voyages, while the sailors who had been given the other treatments remained uncured. (12 Dec 1998) |
| volume-controlled respirator | A respirator that provides a predetermined volume of gases during inhalation, with the pressure required to move that volume remaining variable, depending upon resistance. (05 Mar 2000) |
| microscopically controlled surgery | Minimally invasive surgery, operative procedure performed in a manner derived to result in the smallest possible incision or no incision at all; includes laparoscopic, laparoscopically assisted, thoracoscopic, and endoscopic surgical procedures. Synonym: Mohs' chemosurgery. (05 Mar 2000) |
| condensing, controlled extraction turbines | A controlled turbine that bleeds off (condenses) part of the main stream flow at one (single extraction) or two (double extraction) points. Used when process steam is required at pressures below the inlet pressure and above the exhaust pressure. (05 Dec 1998) |
| controlled clinical trial | A clinical trial involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicine, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trial is characterised as a randomised controlled trial. However, trials employing treatment allocation methods such as coin flips, odd-even numbers, patient social security numbers, days of the week, medical record numbers, or other such pseudo- or quasi-random processes are simply designated as controlled clinical trials. (12 Dec 1998) |
| controlled clinical trials | Clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterised as randomised controlled trials. However, trials employing treatment allocation methods such as coin flips, odd-even numbers, patient social security numbers, days of the week, medical record numbers, or other such pseudo- or quasi-random processes, are simply designated as controlled clinical trials. (12 Dec 1998) |
| controlled hypotension | Deliberate acute reduction of arterial blood pressure to reduce operative blood loss by pharmacologic means during anaesthesia and surgery. (05 Mar 2000) |
| controlled mechanical ventilation | Artificial ventilation in which all inspirations are provided by positive pressure applied to the airway. Synonym: continuous positive pressure breathing, continuous positive pressure ventilation, intermittent positive pressure breathing, intermittent positive pressure ventilation. (05 Mar 2000) |
| controlled respiration | Intermittent application of mechanically or manually generated positive pressure to gas(es) in or about the airway as a means of forcing gases into the lungs in the absence of spontaneous ventilatory efforts. Synonym: controlled respiration. (05 Mar 2000) |
| controlled substance | A substance subject to the Controlled Substances Act (1970), which regulates the prescribing and dispensing, as well as the manufacturing, storage, sale, or distribution of substance's assigned to five schedules according to their 1) potential for or evidence of abuse, 2) potential for psychic or physiologic dependence, 3) contributing a public health risk, 4) harmful pharmacologic effect, or 5) role as a precursor of other controlled substance's. (05 Mar 2000) |