cytochrome P-450 : KMLE 의학 검색 엔진 - 의학사전, 의학용어, 의학약어, 의학논문, 약품/의약품 검색

MeSH(Medical Subject Headings) 맞춤 검색 (http://www.nlm.nih.gov) 결과 : 3 페이지: 2

Cytochrome P-450 CYP2E1 - 새창 An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include alcohol; NITROSAMINES; BENZENE; URETHANE; and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
Synonyms : CYP 2E1, CYP IIE1, CYPIIE1, Cytochrome P-450 (ALC), Cytochrome P-450 IIE1, Cytochrome P-450-J, Cytochrome P450 2E1, N-Nitrosodimethylamine Demethylase, 4 Nitrophenol 2 Hydroxylase, Cytochrome P 450 CYP2E1, Cytochrome P 450 IIE1, Cytochrome P 450 J
Cytochrome P-450 CYP3A - 새창 A cytochrome P-450 monooxygenase that is involved in an NADPH-dependent electron transport pathway by oxidizing a variety of structurally unrelated compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
Synonyms : Cytochrome P-450IIIA, Cytochrome P450 3A, Erythromycin N-Demethylase, Cytochrome P 450 CYP3A, Cytochrome P 450IIIA, Erythromycin N Demethylase, N-Demethylase, Erythromycin, P-450 CYP3A, Cytochrome, P-450IIIA, Cytochrome, P450 3A, Cytochrome
Cytochrome P-450 Enzyme System - 새창 A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Synonyms : Cytochrome P-450 Monooxygenase, Cytochrome P-450 Oxygenase, Cytochrome P450, Cytochrome P 450, Cytochrome P 450 Dependent Monooxygenase, Cytochrome P 450 Enzyme System, Cytochrome P 450 Monooxygenase, Cytochrome P 450 Oxygenase, Monooxygenase, Cytochrome P-450