| cyclic haematopoiesis | An autosomal recessive, inherited immunodeficiency of gray collie dogs characterised by overwhelming recurrent bacterial infections, bleeding, and coat colour dilution. Synonym: gray collie syndrome. (05 Mar 2000) |
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| cyclic imp | <chemical> Inosine cyclic 3',5'-(hydrogen phosphate). An inosine nucleotide which acts as a mild inhibitor of the hydrolysis of cyclic AMP and cyclic GMP and as an inhibitor of cat heart cyclic AMP phosphodiesterase. Chemical name: Inosine, cyclic 3',5'-(hydrogen phosphate) (12 Dec 1998) |
| cyclic inositol phosphate | 1, 2 cyclic derivatives of inositol phosphatide that are invariably formed during enzymic hydrolysis of phosphatidyl inositol species. Have been proposed as second messengers in hormone activated pathways. (18 Nov 1997) |
| cyclic neutropenia | Neutropenia recurring at regular intervals (14 to 45 days), in association with various types of infectious diseases, e.g., stomatitis, cutaneous ulcers, furuncles, arthritis, and others. Synonym: cyclic neutropenia. (05 Mar 2000) |
| cyclic nucleotide | A nucleoside monophosphate in which the phosphoryl group is linked twice to the sugar moiety; e.g., adenosine 3',5'-cyclic monophosphate (cAMP). (05 Mar 2000) |
| cyclic nucleotide-regulated protein kinases | <enzyme> A group of enzymes that catalyses the phosphorylation of serine or threonine residues of proteins and is dependent on cyclic nucleotides. Registry number: EC 2.7.10.- (12 Dec 1998) |
| cyclic peptide | A peptide that forms a ring structure; e.g., tyrocidin A, an antibiotic, is a cyclic decapeptide; valinomycin is a cyclic depsipeptide. (05 Mar 2000) |
| cyclic phosphate | An activator of phosphorylase kinase and an effector of other enzymes, formed in muscle from ATP by adenylate cyclase and broken down to 5'-AMP by a phosphodiesterase; sometimes referred to as the "second messenger." A related compound (2',3') is also known. Synonym: cyclic adenylic acid, cyclic AMP, cyclic phosphate. Acronym: cAMP (05 Mar 2000) |
| cyclic phosphoric acid | In general, a linear polymer of phosphoric acid residues in pyrophosphate linkage in which the a and ω residues are similarly linked to make one endless loop or cyclic compound, specifically, a generic term applied to compounds in which one phosphoric acid residue is esterified to two hydroxyl groups of a single carbon chain, as in adenosine 3',5'-phosphoric acid, adenosine 2',3'-phosphoric acid, etc. (05 Mar 2000) |
| cyclic phosphorylation | Any process in which a phosphatide ester forms a cylic diester by linkage to a neighbouring hydroxyl group. (18 Nov 1997) |
| cyclic photophosphorylation | Process by which light energy absorbed by photosystem I in the chloroplast can be used to generate ATP without concomitant reduction of NADP or other electron acceptors. Energised electrons are passed from PS I to ferredoxin and thence along a chain of electron carriers and back to the reaction centre of PS I, generating ATP en route. (18 Nov 1997) |
| cyclic strabismus | A strabismus that appears and disappears in rhythym, most frequently at 48-hour intervals. (05 Mar 2000) |
| cyclic uridine 3',5'-monophosphate | A cyclic nucleotide involved in metabolic regulation; inhibits the growth of some tumours. (05 Mar 2000) |
| 2',3'-cyclic-nucleotide phosphodiesterases | <enzyme> Nucleoside-2',3'-cyclic phosphate nucleotidohydrolase. Enzymes that catalyze the hydrolysis of the 2'- or 3'- phosphate bonds of 2',3'-cyclic nucleotides. Also hydrolyzes nucleoside monophosphates. Registry number: EC 3.1.4.- (12 Dec 1998) |
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| 3',5'-cyclic AMP synthetase | <enzyme> Enzyme responsible for the ATP. (06 May 1997) |
| 3',5'-cyclic-GMP phosphodiesterase | <enzyme> An enzyme that catalyses the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate. Chemical name: 3',5'-Cyclic-GMP 5'-nucleotidohydrolase Registry number: EC 3.1.4.35 (12 Dec 1998) |
| 3',5'-cyclic-nucleotide phosphodiesterase | <enzyme> An enzyme that catalyses the hydrolysis of cyclic AMP to form adenosine 5'-phosphate. The enzyme is widely distributed in animal tissue and controls the level of intracellular cyclic AMP. Also acts on 3',5'-cyclic imp and 3',5'-cyclic GMP. Chemical name: 3',5'-Cyclic-nucleotide 5'-nucleotidohydrolase Registry number: EC 3.1.4.17 (12 Dec 1998) |
| 8-bromo cyclic adenosine monophosphate | <chemical> 8-bromoadenosine cyclic 3',5'-(hydrogen phosphate). A long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase. Chemical name: Adenosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate) (12 Dec 1998) |