| nonimmune agglutination | <haematology> Agglutination caused by a lectin having a degree of specificity, the mechanism of which is not understood, agglutination that results from non-specific factors, as in the case of acid agglutination or spontaneous agglutination. (05 Mar 2000) |
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| direct agglutination | A general term for techniques which use the agglutination (macroscopic clumping) of particulate reagents as an indicator of the presence of an antigen-antibody reaction. Examples (haemagglutination, latex agglutination and coagglutination) follow. (05 Mar 2000) |
| immune agglutination | Agglutination caused by antibody (agglutinin) that is specific for the suspended microorganism, cell, or for an antigen that has been coated on a particle of suitable size. (05 Mar 2000) |
| indirect agglutination | Agglutination of particles that have been coated with soluble antigen, by antiserum specific for the adsorbed antigen. Synonym: indirect agglutination. (05 Mar 2000) |
| false agglutination | 1. Agglomeration of particles in solution which does not involve antigen-antibody combination. Synonym: false agglutination. Synonym: rouleaux formation. (05 Mar 2000) |
| latex agglutination | Also known as latex particle agglutination, for detection of antibodies is identical to haemagglutination in principle, but the substitution of smaller, antigen-coated latex particles for erythrocytes results in improved sensitivity and reagent longevity. Alternatively, antibodies can be absorbed to the latex particles (under appropriate ionic and pH conditions) by binding to the Fc region of antibodies, leaving the Fab region free to interact with antigens present in the applied specimens. This phenomenon has made latex agglutination a popular technique for detecting antigens as well. (05 Mar 2000) |
| paroxysmal cold haemoglobinuria | <haematology> A rare blood disorder caused by antibodies which destroy red blood cells upon exposure to the cold. The antibodies are formed against a specific blood group and are triggered by the cold. The cause is unknown but the disease has been associated with syphilis and some viral infections. Serum haemoglobin and urine haemoglobin are increased during the attacks. The disease is chronic and treatment is difficult. Some cases resolve spontaneously without treatment. Origin: Gr. Ouron = urine (27 Sep 1997) |
| rose cold | Allergic rhinitis occurring in the spring and early summer. (05 Mar 2000) |
| warm-cold haemolysin | Haemolysin which combines with red blood cells at temperatures below 20캜 and are eluted at warmer temperatures, e.g., 30 to 37캜. See: Donath-Landsteiner cold autoantibody, haemagglutinating cold autoantibody. (05 Mar 2000) |
| cold | <virology> A slang term that describes a viral upper respiratory infection which results from inflammation of the mucous membranes of the nasal cavity. (27 Sep 1997) |
| cold abscess | An abscess without heat or other usual signs of inflammation. Synonym: tuberculous abscess. (05 Mar 2000) |
| cold agglutinin | An antibody which reacts more efficiently at temperatures below 37캜. (05 Mar 2000) |
| cold agglutinins | <haematology> Antibodies that agglutinate particles with greater activity below 32쵣. They are IgM antibodies specifically reactive with blood groups I and i in humans and agglutinate red blood cells on cooling, causing Raynaud's phenomenon in vivo. (18 Nov 1997) |
| cold allergy | Physical symptoms produced by hypersensitivity to cold. (05 Mar 2000) |
| cold antibody | See: cold agglutinin. (05 Mar 2000) |