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DNAse i hypersensitivity site <molecular biology> A site on a DNA molecule that is especially prone to being cut apart by the endonuclease enzyme DNase I, which breaks down DNA into smaller fragments by cleaving phosphodiester bonds. These sites tend to be near active genes, which are regularly transcribed.
(09 Oct 1997)
drug hypersensitivity Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
(12 Dec 1998)
immediate hypersensitivity An exaggerated immune response mediated by antibodies, in particular IgE.
See: allergy.
(05 Mar 2000)
immediate hypersensitivity reaction An immune response mediated by antibody, usually IgE, which occurs within minutes after a second encounter with an antigen, resulting in the release of histamine and subsequent swelling and vasodilation.
(05 Mar 2000)
tuberculin-type hypersensitivity A local or generalised response that begins 24 to 48 hours after exposure to an antigen.
See: cell-mediated reaction.
Synonym: contact hypersensitivity, delayed hypersensitivity, late reaction, tuberculin-type hypersensitivity.
(05 Mar 2000)
type III hypersensitivity reaction An immunologic category of diseases evoked by the deposition of antigen-antibody or antigen-antibody-complement complexes on cell surfaces, with subsequent involvement of breakdown products of complement, platelets, and polymorphonuclear leukocytes, and development of vasculitis; nephritis is common. Arthus phenomenon and serum sickness are classic examples, but many other disorders, including most of the connective tissue disease's, may belong in this immunologic category; immune complex disease's can also occur during a variety of disease's of known aetiology, such as subacute bacterial endocarditis.
See: autoimmune disease.
Synonym: immune complex disorder, type III hypersensitivity reaction.
(05 Mar 2000)
food hypersensitivity Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens ingested in food.
(12 Dec 1998)
T-cell-rich, B-cell lymphoma <tumour> A B-cell lymphoma in which more than 90% of the cells are of T-cell origin, masking the large cells that form the neoplastic B-cell component.
See: adult T-cell lymphoma.
(05 Mar 2000)
absorption cell A small glass chamber with parallel sides, in which absorption spectra of solutions can be obtained.
(05 Mar 2000)
acid cell One of the cell's of the gastric glands; it lies upon the basement membrane, covered by the chief cell's, and secretes hydrochloric acid that reaches the lumen of the gland through fine intracellular and intercellular canals (canaliculi).
Synonym: acid cell, oxyntic cell.
(05 Mar 2000)
acidophil cell A cell whose cytoplasm or its granules stain with acid dyes.
(05 Mar 2000)
acinar cell Any secreting cell lining an acinus, especially applied to the cell's of the pancreas that furnish pancreatic juice and enzymes to distinguish them from the cell's of ducts and the islets of Langerhans.
Synonym: acinous cell.
(05 Mar 2000)
acinar cell tumour A solid and cystic tumour of the pancreas, occurring in young women; tumour cells contain zymogen granules.
(05 Mar 2000)
acinic cell adenocarcinoma <tumour> An adenocarcinoma arising from secreting cells of a racemose gland, particularly the salivary glands.
Synonym: acinar carcinoma, acinic cell carcinoma, acinose carcinoma, acinous carcinoma.
(05 Mar 2000)
acinic cell carcinoma <tumour> An adenocarcinoma arising from secreting cells of a racemose gland, particularly the salivary glands.
Synonym: acinar carcinoma, acinic cell carcinoma, acinose carcinoma, acinous carcinoma.
(05 Mar 2000)
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