| Warburg-Dickens-Horecker shunt | <biochemistry> A pathway of hexose oxidation in which glucose-6-phosphate undergoes two successive oxidations by NADP, the final one being an oxidative decarboxylation to form a pentose phosphate. Diverges from this when glucose-6-phosphate is oxidized to ribose 5 phosphate by the enzyme glucose-6 phosphate dehydrogenase. This step reduces NADP to NADPH, generating a source of reducing power in cells for use in reductive biosyntheses. In plants, part of the pathway functions in the formation of hexoses from carbon dioxide in photosynthesis. Also important as source of pentoses, for example for nucleic acid biosynthesis. This pathway is the main metabolic pathway in neutrophils, congenital deficiency in the pathway produces sensitivity to infection. Alternative metabolic route to Embden Meyerhof pathway for breakdown of glucose. (18 Nov 1997) |
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| Warburg-Lipmann-Dickens-Horecker shunt | <biochemistry> A pathway of hexose oxidation in which glucose-6-phosphate undergoes two successive oxidations by NADP, the final one being an oxidative decarboxylation to form a pentose phosphate. Diverges from this when glucose-6-phosphate is oxidized to ribose 5 phosphate by the enzyme glucose-6 phosphate dehydrogenase. This step reduces NADP to NADPH, generating a source of reducing power in cells for use in reductive biosyntheses. In plants, part of the pathway functions in the formation of hexoses from carbon dioxide in photosynthesis. Also important as source of pentoses, for example for nucleic acid biosynthesis. This pathway is the main metabolic pathway in neutrophils, congenital deficiency in the pathway produces sensitivity to infection. Alternative metabolic route to Embden Meyerhof pathway for breakdown of glucose. (18 Nov 1997) |
| Warren shunt | Anastomosis of the splenic end of the divided splenic vein to the left renal vein. Synonym: distal splenorenal shunt. (05 Mar 2000) |
| Waterston shunt | Creation of a narrow (about 3 mm) opening between the ascending aorta and the subjacent right pulmonary artery to increase pulmonary circulation in cyanotic heart disease with decreased pulmonary flow. (05 Mar 2000) |
| complications of ventriculo-peritoneal shunt | <radiology> Kinking, interruption, exit from peritoneal cavity with growth, through processus vaginalis to scrotum, CSFoma, mass effect exhibited on bowel gas pattern with malfunctioning shunt, lack of movement of shunt tip with positional or temporal change, perforation of hollow viscus (e.g., bowel or bladder) (12 Dec 1998) |
| portacaval shunt | Surgical anastomosis between portal and systemic veins, surgical anastomosis between the portal vein and the vena cava, as in an Eck fistula. (05 Mar 2000) |
| portacaval shunt, surgical | Surgical portasystemic shunt between the portal vein and inferior vena cava. (12 Dec 1998) |
| portasystemic shunt | A shunt between any parts of the portal and systemic venous systems, including portacaval, mesocaval, splenorenal shunt's or spontaneously occurring shunt's. (05 Mar 2000) |
| portasystemic shunt, surgical | Surgical venous shunt between the portal and systemic circulation to effect decompression of the portal circulation. It is performed primarily in the treatment of bleeding oesophageal varices resulting from portal hypertension. Types of shunt include portacaval, splenorenal, mesocaval, splenocaval, left gastric-caval (coronary-caval), portarenal, umbilicorenal, and umbilicocaval. (12 Dec 1998) |
| portasystemic shunt, transjugular intrahepatic | A type of surgical portasystemic shunt to reduce portal hypertension with associated complications of oesophageal varices and ascites. It is performed percutaneously through the jugular vein and involves the creation of an intrahepatic shunt between the hepatic vein and portal vein. The channel is maintained by a metallic stent. The procedure can be performed in patients who have failed sclerotherapy and is an additional option to the surgical techniques of portocaval, mesocaval, and splenorenal shunts. It takes one to three hours to perform. (jama 1995;273(23):1824-30) (12 Dec 1998) |
| hexose monophosphate shunt | The main metabolic pathway in activated neutrophils, rendering them relatively insensitive to inhibitors of oxidative phosphorylation. Congenital deficiency of the first enzyme in the shunt, glucose 6 phosphate dehydrogenase, produces a sensitivity to infection similar to that seen in chronic granulomatous disease. (18 Nov 1997) |
| Scribner shunt | Connection of an artery, customarily the radial, to the cephalic vein via a short extracorporeal catheter. (05 Mar 2000) |
| H shunt | <surgery> A side-to-side shunt between adjacent vessels which utilises a connecting conduit. Synonym: H graft. (05 Mar 2000) |
| shunt | 1. To turn to one side, to divert, to bypass. 2. <cardiology> A passage or anastomosis between two natural channels, especially between blood vessels. Such structures may be formed physiologically (for example to bypass a thrombosis) or they may be structural anomalies. 3. <surgery> A surgically created anastomosis, also, the operation of forming a shunt. (18 Nov 1997) |
| shunt, left to right | A term used to describe the diversion of blood from the higher pressure left side of the heart to the right side (pulmonary circuit). Can be seen in ventricular septal defect, atrial septal defect and patent ductus arteriosus (congenital at birth). (27 Sep 1997) |