| Tec protein-tyrosine kinase | <enzyme> Member of the cytoplasmic ptks of the non-src family; associates with lyn ptk; n-terminal amino acid sequence given in first source Registry number: EC 2.7.1.- Synonym: tec ptk, tec kinase, tec tyrosine kinase (26 Jun 1999) |
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| TIE-2 receptor tyrosine kinase | <enzyme> Expressed in developing vascular endothelial cells; unlike tie-1, also expressed in lens epithelium and heart epicardium; has the same organization of amino acid sequence motifs characteristic of tie-1; aa sequence of the intracellular and extracellular regions of tie-1 and tie-2 are 79% and 32% identical, respectively; aa sequence of both kinases given in first source Registry number: EC 2.7.10.- Synonym: tie-2-rtk (26 Jun 1999) |
| tie receptor tyrosine kinase | <enzyme> From human leukaemia cells; expressed in developing vascular endothelial cell; has homology with egf, bfgf, csf-1, pdgf and stem cell factor receptors; ligand and biologic function not known as of 12/92; tie-1 receptor tyrosine kinase is rat homolog of tie receptor tyrosine kinase; aa sequence known Registry number: EC 2.7.10.- Synonym: tie-1 receptor tyrosine kinase, tie-1 rtk (26 Jun 1999) |
| emb protein-tyrosine kinase | <enzyme> Isolated from murine mast cells Registry number: EC 2.7.1- Synonym: emb ptk (26 Jun 1999) |
| emt protein-tyrosine kinase | <enzyme> Isolated from murine mast cells Registry number: EC 2.7.1.- Synonym: emt ptk, itk protein, itk gene product, tsk protein, inducible t cell kinase (26 Jun 1999) |
| epidermal growth factor receptor protein-tyrosine kinase | <enzyme> The catalytic protein-tyrosine kinase domain found on the cytoplasmic beta-portion of epidermal growth factor receptor. Registry number: EC 2.7.1.- (12 Dec 1998) |
| estradiol receptor tyrosine kinase | <enzyme> Calcium and calmodulin dependent Registry number: EC 2.7.1.- Synonym: ertk (26 Jun 1999) |
| tyrosine kinase | <enzyme> Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling and can be divided into two subfamilies: receptor tyrosine kinases, that have an extracellular ligand binding domain, a single transmembrane domain and an intracellular tyrosine kinase domain and nonreceptor tyrosine kinases, which are soluble, cytoplasmic kinases. (18 Nov 1997) |
| lymphocyte specific protein tyrosine kinase p56(lck) | <enzyme> This enzyme is a lymphoid specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the il-2 receptor, and is thought to be involved in the earliest steps of tcr-mediated T-cell activation. Registry number: EC 2.7.11.- (12 Dec 1998) |
| AMP-activated protein kinase kinase | <enzyme> An endogenous kinase kinase; reactivates the inactive form of AMP-activated protein kinase (AMP-pk); phosphorylates the 63-kD subunit of AMP-pk Registry number: EC 2.7.1.- Synonym: AMP-pk reactivator, hmg CoA reductase kinase kinase (26 Jun 1999) |
| calmodulin-dependent protein kinase IV kinase | <enzyme> Phosphorylates and activates cam-kinase iv; from brain Registry number: EC 2.7.10.- Synonym: cam-kinase iv kinase (26 Jun 1999) |
| MAPKAP kinase-2 reactivating kinase | <enzyme> A mapk-like enzyme; homologous to p42(mapk) and p44(mapk); activated by phosphorylation of serine/threonine and tyrosine residues Registry number: EC 2.7.1.- Synonym: mapkap kinase-2 rk (26 Jun 1999) |
| ribosomal protein S6 kinase kinase | <enzyme> Isolated from unfertilised xenopus eggs; a 41 kD enzyme that is associated, in vivo, with phosphorylation on threonine and tyrosine residues and, in vitro, with phosphorylation on serine as well Registry number: EC 2.7.1.- Synonym: rsk kinase (26 Jun 1999) |
| protein kinase B kinase | <enzyme> Phosphorylates and activates protein kinase b on threonine-308; requires phosphatidylinositol-3,4,5-trisphosphate Registry number: EC 2.7.10.- Synonym: upstream kinase, pkb kinase (26 Jun 1999) |
| PEP protein tyrosine phosphatase | <enzyme> Pest - pro, glu, ser and thr; an intracellular ptpase expressed primarily by cells of haematopoietic origin; involved in regulating nuclear tyrosine phosphorylation; amino acid sequence has been determined Registry number: EC 3.1.3.- Synonym: pep ptpase, pest-enriched phosphatase, ptp-pest (26 Jun 1999) |