| amyloid beta-protein precursor | A precursor to the amyloid-beta protein (beta/a4). Alterations in the expression of the amyloid beta-protein precursor (abpp) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both alzheimer disease and down syndrome. Abpp is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/a4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in alzheimer disease, down syndrome and, to a limited extent, in normal aging. (12 Dec 1998) |
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| amyloid bodies of the prostate | An obsolete term for small masses of colloid material often present in the tubules of the gland. See: corpus amylaceum. (05 Mar 2000) |
| amyloid corpuscle | One of a number of small ovoid or rounded, sometimes laminated, bodies resembling a grain of starch and found in nervous tissue, in the prostate, and in pulmonary alveoli; of little pathological significance, and apparently derived from degenerated cells or proteinaceous secretions. Synonym: amniotic corpuscle, amylaceous corpuscle, amyloid corpuscle, colloid corpuscle. (05 Mar 2000) |
| amyloid degeneration | Infiltration of amyloid between cells and fibres of tissues and organs. Synonym: waxy degeneration. (05 Mar 2000) |
| amyloid kidney | A kidney in which amyloidosis has occurred, usually in association with some chronic illness such as multiple myeloma, tuberculosis, osteomyelitis, or other chronic suppurative inflammation; such kidney's are moderately enlarged and grossly manifest a waxy appearance, with amyloid deposited beneath the endothelium in the glomerular loops and in the arterioles, apparently beginning as foci of thickening of the basement membranes. Synonym: waxy kidney. (05 Mar 2000) |
| amyloid nephrosis | The nephrotic syndrome due to deposition of amyloid in the kidney. See: renal amyloidosis. (05 Mar 2000) |
| amyloid neuropathies | Disorders of the peripheral nervous system associated with deposition of amyloid. Amyloid neuropathies may result from non-hereditary or hereditary amyloidosis. Several different forms of familial amyloid neuropathies have been described, most of which have specific mutations in the prealbumin gene. (12 Dec 1998) |
| amyloid p component | Amyloid p component is a small, non-fibrillar glycoprotein found in normal serum and in all amyloid deposits. It has a pentagonal (pentaxin) structure. It acts as an acute phase protein in the mouse, modulates immunologic responses in man, inhibits elastase, and has been suggested as an indicator of liver disease. (12 Dec 1998) |
| amyloid precursor protein | <protein> Individuals with Alzheimer's disease are characterised by extensive accumulation of amyloid in the brain, referred to as senile plaques. These consist of a core of amyloid fibrils surrounded by dystrophic neurites. The principal component of the amyloid fibrils is B/A4, a peptide derived from the larger APP. The specific role of amyloid protein is unclear but it is thought that amyloid deposits may cause neurons to degenerate. Amyloid deposits also occur in brains of older Down's Syndrome patients. (04 May 1997) |
| amyloid protein | Glycoprotein deposited extracellularly in tissues in amyloidosis. The glycoprotein may either derive from light chain of immunoglobulin (AIO (amyloid of immune origin): 5-18 kD glycoprotein, product of a single clone of plasma cells, the N terminal part of lambda or kappa light chain) or, in what used to be referred to as AUO, amyloid of unknown origin, from serum amyloid A (SAA), one of the acute phase proteins that increases many fold in inflammation. The polypeptides are organised as a _ pleated sheet making the material rather inert and insoluble. Minor protein components are also found. Should be distinguished from _ amyloid deposited in the brain and that is derived from amyloid precursor protein (see amyloidogenic glycoprotein. (18 Nov 1997) |
| amyloid protein aa | A nonimmunoglobulin amyloid isolated from amyloid fibrils deposited in amyloidosis secondary to chronic inflammatory diseases such as rheumatoid arthritis. Antisera to amyloid protein aa have been used to detect a related serum protein saa. (12 Dec 1998) |
| amyloid protein saa | A serum protein believed to be a circulating precursor to amyloid protein aa. It is present in low concentrations in normal sera, but found in much higher concentrations in sera of older persons and in patients with amyloidosis or with diseases known to predispose to amyloidosis. Very high levels of this protein have been reported during acute inflammatory episodes. Antisera to amyloid protein aa cross-react with protein saa. (12 Dec 1998) |
| amyloid tumour | A localised form of amyloidosis in which amyloid occurs as masses or nodules beneath the skin or mucous membranes, e.g., in the larynx. Synonym: amyloid tumour, focal amyloidosis. (05 Mar 2000) |
| amyloidal | Resembling or containing amyl; starchlike. <medicine> Amyloid degeneration, a diseased condition of various organs of the body, produced by the deposit of an albuminous substance, giving a blue colour with iodine and sulphuric acid. Synonym: waxy or lardaceous degeneration. Origin: L. Amylum starch. Source: Websters Dictionary (01 Mar 1998) |
| amyloidogenic glycoprotein | <protein> An integral membrane glycoprotein of the brain and related to the Drosophila vnd gene product. A precursor of _ amyloid, that accumulates in Alzheimer's disease and Down's syndrome. See: amyloid precursor protein. (18 Nov 1997) |
Synonyms : APP Secretase, Amyloid Precursor Protein Secretase, Secretase, Secretases, alpha-Secretase, beta-Secretase, gamma-Secretase, Secretase, APP, alpha Secretase, beta Secretase, gamma Secretase
Synonyms : Amyloidoses
Synonyms : Amyloidoses, Familial, Amyloidoses, Hereditary, Familial Amyloidoses, Familial Amyloidosis, Hereditary Amyloidoses, Hereditary Amyloidosis
Synonyms :
Synonyms :
| amyloid light chain protein |
a pathological fibrillar low-molecular-weight protein occurring in immunocyte-derived amyloidosis; it is structurally and immunologically similar to the variable region of either the kappa chains or the lambda chains of immunoglobulins. Called also AL p. See also amyloid (def. 3).
출처: www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspz...
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| amyloid polyneuropathy |
polyneuropathy caused by amyloidosis; symptoms may include dysfunction of the autonomic nervous system, carpal tunnel syndrome, and sensory disturbances in the extremities such as numbness, hyperesthesia, or paresthesia. See also familial amyloid p.
출처: www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspz...
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| amyloidosis |
A group of diseases in which protein is deposited in specific organs (localized amyloidosis) or throughout the body (systemic amyloidosis). Amyloidosis may be either primary (with no known cause) or secondary (caused by another disease, including some types of cancer). Generally, primary amyloidosis affects the nerves, skin, tongue, joints, heart, and liver; secondary amyloidosis often affects the spleen, kidneys, liver, and adrenal glands.
출처: www.stjude.org/glossary
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| amyloidosis |
A rare condition in which certain blood cells produce an abnormal protein that deposits in the tissues. If the deposits are in the heart, heart failure can result.
출처: www.bdid.com/termsa.htm
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| amyloid |
Of spore walls, spore ornamentation, hyphal walls, ascus tips, etc.: Staining blue or grayish to blackish-violet in Melzer's reagent, presumably because of the presence of starch or a starch-like compound. (17)
출처: ppathw3.cals.cornell.edu/glossary/Defs_A.htm
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