| blocking agent | A class of drugs that inhibit (block) a biologic activity or process, such as axonal conduction or transmission, or ions across a cell membrane; frequently called "blockers." (05 Mar 2000) |
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| blocking antibody | An antibody used in a reaction to prevent some other reaction taking place, for example one antibody competing with another for a cell surface receptor. See: desensitisation. (18 Nov 1997) |
| ganglionic blocking agent | An agent that impairs the passage of impulses in autonomic ganglia. (05 Mar 2000) |
| Rh blocking test | A test for nonagglutinating Rh antibodies: an Rh agglutination test is first carried out; if the test for Rh agglutinins is negative, then 1 drop of anti-Rho agglutinating serum of moderate titre is mixed with the patient's serum containing Rh-positive test cells; if after incubating for from 1 to 2 hr at 37캜 no agglutination occurs, Rho-blocking antibodies are assumed to be present in the patient's serum. (05 Mar 2000) |
| slow channel-blocking agent | calcium channel-blocking agent |
| spermatogenesis-blocking agents | Chemical substances which inhibit the process of spermatozoa formation at either the first stage, in which spermatogonia develop into spermatocytes and then into spermatids, or the second stage, in which spermatids transform into spermatozoa. (12 Dec 1998) |
| neuromuscular blocking agent | A group of drugs that prevent motor nerve endings from exciting skeletal muscle. They act either by competing for the neurotransmitter, acetylcholine, (like D-tubocurarine, mivacurium and pancuronium), or by first stimulating the postjunctional muscle membrane and subsequently desensitizing the muscle endplates to the acetylcholine (like succinylcholine or decamethonium); used in surgery to produce paralysis and facilitate manipulation of muscles. (05 Mar 2000) |
| neuromuscular blocking agents | Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (neuromuscular nondepolarising agents) or noncompetitive, depolarising agents (neuromuscular depolarising agents). Both prevent acetylcholine from triggering the muscle contraction and they are used as anaesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc. (12 Dec 1998) |
| nondepolarising neuromuscular blocking agent | A compound that paralyzes skeletal muscle primarily by inhibiting transmission of nerve impulses at the neuromuscular junction rather than by affecting the membrane potention of motor endplate or muscle fibres. (05 Mar 2000) |
| alpha, alpha-phosphotrehalase | <enzyme> Forms glucose plus glucose-6-phosphate Registry number: EC 3.2.1.93 Synonym: trehalose-6-phosphate hydrolase, phospho-alpha(1,1)glucosidase, trea gene product, trec gene product (26 Jun 1999) |
| alpha,alpha-trehalose phosphorylase | <enzyme> Chemical name: alpha-d-glucopyranosyl-alpha-d-glucopyranose orthophosphate glucosyltransferase Registry number: EC 2.4.1.64 Synonym: trehalose phosphorylase (26 Jun 1999) |
| alpha-dextrin endo-1,6-alpha-glucosidase | <enzyme> An enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullalan, amylopectin, and glycogen, and in alpha-and beta-amylase limit-dextrins of amylopectin and glycogen. Compare: isoamylase. Synonym: limit dextrinase, pullulanase, R enzyme. (05 Mar 2000) |
| alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase | <enzyme> Involved in degradation of vitamin b6; forms acetic acid plus ammonia plus carbon dioxide plus alpha-hydroxymethyl-succinic monoaldehyde Registry number: EC 3.5.1.- Synonym: compound b hydrolase (26 Jun 1999) |
| cholesterol-5 alpha,6 alpha-epoxide hydrase | <enzyme> Aspect of epoxide hydrolase, EC 3.3.2.3 Pharmacological action: carcinogen Registry number: EC 3.3.2.- Synonym: cholesterol epoxide hydrase, cholesterol epoxide hydrolase (26 Jun 1999) |
| CMP-acetylneuraminate-alpha-N-acetylneuramide alpha-2,8-sialyltransferase | <enzyme> Forms ganglioside gd3 Registry number: EC 2.4.99.8 Synonym: cmp-n-acetylneuraminate-gm3 sialyltransferase, gm3-sialosyltransferase, gd3 synthase, gd3-synthase, cmp-n-acetylneuraminate-(n-acetylneuraminyl)-d-galactosyl-d-glucosylceramide sialyltransferase, sialyltransferase II, st II, g(m3) alpha-2,8-sialyltransferase, st8sia I, stii enzyme, stiii enzyme, gt3 synthase (26 Jun 1999) |