| 5 alpha-3 alpha-hydroxysteroid dehydrogenase |
<enzyme> Androsterone can be substrate
Registry number: EC 1.1.1.50
Synonym: 3 alpha-hydroxysteroid dehydrogenase, 3 alpha-hydroxysteroid oxidoreductase, 3 oc-hydroxysteroid dehydrogenase
(26 Jun 1999) |
| 5 alpha-androstane-3 beta,17 beta-diol 6 alpha-hydroxylase |
<enzyme> Requires NADPH, found in rat prostatic microsomes
Registry number: EC 1.14.13.-
Synonym: artdl 6 alpha-hydroxylase
(26 Jun 1999) |
| 5 alpha-androstane 3 beta,17 beta-diol 7 alpha-hydroxylase |
<enzyme> Requires NADPH, found in rat prostate microsomes
Registry number: EC 1.14.13.-
Synonym: artdl 7 alpha-hydroxylase
(26 Jun 1999) |
| 5 alpha-dihydroprogesterone 3 alpha-hydroxysteroid oxidoreductase |
<enzyme> Catalyses conversion of 5 alpha-dihydroprogesterone to 3 alpha -hydroxy-5 alpha-pregnane-20-one
Registry number: EC 1.1.1.-
Synonym: 5-dp-3 alpha-hso, NADPH-5 alpha-dihydroprogesterone 3 alpha-hydroxysteroid oxidoreductase, alpha-hsor
(26 Jun 1999) |
| 5 beta-cholestane-3 alpha,7 alpha-diol 26-hydroxylase |
<enzyme> Nadp-dependent
Registry number: EC 1.14.13.-
(26 Jun 1999) |
| 7 alpha-hydroxy-4-cholesten-3-one-12 alpha monooxygenase |
<enzyme> Liver microsomal enzyme active in conversion of cholesterol to cholic acid; introduces a 12 alpha-hydroxyl group into the steroid nucleus of cholesterol
Registry number: EC 1.14.99.-
Synonym: 7-hco-monooxygenase, hco 12 alpha-hydroxylase
(26 Jun 1999) |
| acetoacetyl-CoA reductase |
An oxidoreductase catalyzing interconversion of a 3-oxoacyl-CoA and NADPH, and the corresponding d-3-hydroxyacyl-CoA, and NADP+. A step in fatty acid synthesis.
(05 Mar 2000) |
| acetohexamide reductase |
<enzyme> Catalyses the conversion of acetohexamide to (-)-hydroxyhexamide
Registry number: EC 1.1.1.-
(26 Jun 1999) |
| acryloyl-CoA reductase |
<enzyme> Clostridium kluyveri enzyme; contains fmn, ferredoxin, and flavodoxin; can act as electron donors
Registry number: EC 1.3.99.-
Synonym: acryloyo-coenzyme a reductase
(26 Jun 1999) |
| aflatoxin B1 aldehyde reductase |
<enzyme> Catalyses the conversion of the dialdehydic form of aflatoxin b1-dihydrodiol to the dialcohol form
Registry number: EC 1.1.1.-
Synonym: aflatoxin b1-aldehyde reductase, afb1-ar
(26 Jun 1999) |
| aflatoxin B1 reductase |
<enzyme> Reduces the cyclopentenone ring of aflatoxin b1 to aflatoxicol; requires NADPH as cofactor
Registry number: EC 1.1.1.-
(26 Jun 1999) |
| aflatoxin G2a reductase |
<enzyme> Has broad substrate specificity in cell-free extracts from aspergillus parasiticus; versicolorin a hemiacetal is reduced to versicolorin c; 17-hydroxy-16,17-dihydrosterigmatocystin is reduced to a 14,17-hydrated derivative; aflatoxin g2a is converted to a 13,16-hydrated derivative of afg2
Registry number: EC 1.1.1.-
(26 Jun 1999) |
| aldehyde reductase |
<enzyme> An enzyme that catalyses reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses.
Chemical name: Alditol:NAD(P)+ 1-oxidoreductase
Registry number: EC 1.1.1.21
(12 Dec 1998) |
| aldose reductase |
A polyol dehydrogenase (NADP+);an oxidoreductase that reversibly converts aldoses to alditols (e.g., glucose to sorbitol) with NADPH as hydrogen donor. An important step in the metabolism of sorbitol and in the formation of diabetic cataracts.
See: d-sorbitol-6-phosphate dehydrogenase.
(05 Mar 2000) |
| aldose reductase inhibitor |
<pharmacology> A class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes.
Aldose reductase is an enzyme that is normally present in the eye and in many other parts of the body. It helps change glucose (sugar) into a sugar alcohol called sorbitol. Too much sorbitol trapped in eye and nerve cells can damage these cells, leading to retinopathy and neuropathy.
Drugs that prevent or slow (inhibit) the action of aldose reductase are being studied as a way to prevent or delay these complications of diabetes.
(09 Oct 1997) |
