| receptors, leukocyte-adhesion | Family of proteins associated with the capacity of leukocytes, including lymphocytes, monocytes, and neutrophils, to adhere to each other and to certain substrata, e.g., the c3bi component of complement. Members of this family are the lymphocyte function-associated antigen-1 (lfa-1), the macrophage-1 antigen (mac-1), and the antigen p150,95 or p150,95 leukocyte adhesion protein. They all share a common beta-subunit which is the CD18 antigen. All three of the above antigens are absent in inherited leukocyte-adhesion deficiency syndrome, which is characterised by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells. (12 Dec 1998) |
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| cell adhesion | See: adhesins, cadherins, cell adhesion molecules (CAMs), contact sites A, DLVO theory, integrins, sorting out, uvomorulin and various specialised junctions (adherens junctions, desmosomes, focal adhesions, gap junction and zonula occludens). (18 Nov 1997) |
| cell adhesion kinase | <enzyme> From hela cells; involved in cell-cell interactions; genbank l20817 Registry number: EC 2.7.1.- Synonym: cak protein (26 Jun 1999) |
| cell adhesion molecule | <molecular biology> Although this could mean any molecule involved in cellular adhesive phenomena, it has acquired a more restricted sense, namely a molecule on the surface of animal tissue cells, antibodies (or Fab fragments) against that specifically inhibit some form of intercellular adhesion. Examples are Liver Cell Adhesion Molecule and Neural Cell Adhesion Molecule, both named from tissues in which first detected, although their occurrence is not in fact restricted to these. Acronym: CAM (26 Nov 1998) |
| water of adhesion | Water held by molecular attraction in contact with solid surfaces, but not forming an essential part of their constitution. (05 Mar 2000) |
| primary adhesion | Healing by fibrous adhesion, without suppuration or granulation tissue formation. Synonym: primary adhesion, primary union. (05 Mar 2000) |
| secondary adhesion | Delayed closure of two granulating surfaces. Synonym: secondary adhesion, secondary union. (05 Mar 2000) |
| neural cell adhesion molecule | See: NCAM. (18 Nov 1997) |
| differential adhesion | The differential adhesion hypothesis was advanced by Steinberg to explain the mechanism by which heterotypic cells in mixed aggregates sort out into isotypic territories. Quantitative differences in homo and hetero typic adhesion are supposed to be sufficient to account for the phenomenon without the need to postulate cell type specific adhesion systems: fairly generally accepted, although some tissue specific cell adhesion molecules are now known to exist. (18 Nov 1997) |
| immune adhesion test | The diagnostic application of the immune adhesion phenomenon. Synonym: erythrocyte adherence test, immune adhesion test, red cell adherence test. (05 Mar 2000) |
| intercellular adhesion molecule | See: ICAM. (18 Nov 1997) |
| intercellular adhesion molecule-1 | <chemical> A cell-surface ligand with a role in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue. Chemical name: Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced) (12 Dec 1998) |
| interthalamic adhesion | The variable connection between the two thalamic masses across the third ventricle; absent in about 20% of human brains. Synonym: adhesio interthalamica, commissura cinerea, commissura grisea, intermediate mass, massa intermedia. (05 Mar 2000) |
| endothelial-leukocyte adhesion molecule | 115,000 Mw molecule on the surface of endothelial cells that is involved in blood leukocyte attachment to vessel walls as well as emigration from the vessels into the tissues. (05 Mar 2000) |
| fibrinous adhesion | An adhesion that consists of fine threads of fibrin resulting from an exudate of plasma or lymph, or an extravasation of blood. (05 Mar 2000) |