| enzyme-linked immunoabsorbent assay | <investigation> The enzyme-linked immunoabsorbent assay is serologic test used as a general screening tool for the detection of antibodies to the HIV virus. Reported as positive or negative. Since false positive tests due occur (for example recent flu shot), positives will require further evaluation using the western blot. ELISA technology links an a measurable enzyme to either an antigen or antibody. In this way, it can then measure the presence of an antibody or an antigen in the bloodstream. Acronym: ELISA (27 Sep 1997) |
|---|---|
| enzyme-linked immunosorbent assay | An immunoassay utilizing an antibody labelled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. (12 Dec 1998) |
| expression-linked copy | <molecular biology> One of many different versions of the variable surface glycoprotein gene of the trypanosome (a parasitic protozoan which causes the disease African sleeping sickness), refers to whichever one of them is currently being expressed on the outer surface of the trypanosome. (09 Oct 1997) |
| y-linked | A gene on the Y chromosome. A y-linked gene is by necessity passed from father to son. (12 Dec 1998) |
| Y-linked gene | A gene located on a Y chromosome. Synonym: holandric gene. (05 Mar 2000) |
| y-linked inheritance | Inheritance by genes on the y chromosome. Also called holandric inheritance. (12 Dec 1998) |
| Y-linked locus | Any (haploid) locus that in normal karyotypes is borne on the Y chromosome. The known content is so far small. (05 Mar 2000) |
| flavin-linked dehydrogenase | <enzyme> A dehydrogenase that requires a riboflavin coenzyme to function properly. (09 Oct 1997) |
| linked | Said of two genetic loci that exhibit genetic linkage. (05 Mar 2000) |
| linked gene | <genetics> Genes and / or markers that are so closely associated on the chromosome that they are inherited together in 80% or more of cases. (14 Oct 1997) |
| aaa disease | Endemic anaemia of ancient Egypt, ascribed in the Papyrus Ebers to intestinal infestation with ancylostoma; now called ancylostomiasis. (05 Mar 2000) |
| ABO haemolytic disease of the newborn | Erythroblastosis foetalis due to maternal-foetal incompatibility with respect to an antigen of the ABO blood group; the foetus possesses A or B antigen which is lacking in the mother, and the mother produces immune antibody which causes haemolysis of foetal erythrocytes. (05 Mar 2000) |
| accumulation disease | A disease characterised by abnormal accumulation of a metabolic product in certain cells and tissues; examples include the mucopolysaccharidoses, lipoidoses. (05 Mar 2000) |
| Acosta's disease | A condition that results from prolonged exposure to high altitude. Symptoms include a continuous dry cough, shortness of breath, poor exercise tolerance, dizziness, headache, sleep difficulty, anorexia, confusion, fatigue and a rapid pulse. Treatment includes the immediate movement to a lower altitude. Prophylaxis has been accomplished successfully with the use of acetazolamide (Diamox). (27 Sep 1997) |
| acquired immunodeficiency disease | Acquired immunodeficiency disease: Disease caused by infection with the human immunodeficiency virus (HIV). (12 Dec 1998) |