| protein-tyrosine-phosphatase | <enzyme> An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with protein-tyrosine kinase, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. Chemical name: Protein-tyrosine-phosphate phosphohydrolase Registry number: EC 3.1.3.48 (12 Dec 1998) |
|---|---|
| pyp2 protein tyrosine phosphatase | <enzyme> Shares an essential overlapping role with pyp1 ptpase and is 42% identical in sequence in the c-terminal catalytic domain of pyp1; involved in negative regulation of mitosis in fission yeast Registry number: EC 3.1.3.- Synonym: pyp2 ptpase, pyp2 gene product (26 Jun 1999) |
| pyp3 protein tyrosine phosphatase | <enzyme> Acts as mitotic inducer in fission yeast Registry number: EC 3.1.3.- Synonym: pyp3 gene product, pyp3 ptpase (26 Jun 1999) |
| SH protein-tyrosine phosphatase | <enzyme> Has sequence similarity to src-homology region 2 Registry number: EC 3.1.3.- Synonym: sh-ptp3, sh-ptp1, ptp1c, protein-tyrosine-phosphatase 1c, protein tyrosine phosphatase, nonreceptor type 6, ptpn6, shptp1, protein-tyrosine phosphatase shp, shp ptpase, shp-1, shp-2 (26 Jun 1999) |
| stomach cancer-associated protein-tyrosine phosphatase | <enzyme> Human transmembrane-type ptpase expressed in gastric, pancreatic and colourectal cancer cells; consists of 1093 amino acid; mw 200 kD; genbank d15049 Registry number: EC 3.1.3.- Synonym: sap 1 phosphatase (26 Jun 1999) |
| nonreceptor protein tyrosine kinase | <enzyme> Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling and can be divided into two subfamilies: receptor tyrosine kinases, that have an extracellular ligand binding domain, a single transmembrane domain and an intracellular tyrosine kinase domain and nonreceptor tyrosine kinases, which are soluble, cytoplasmic kinases. (18 Nov 1997) |
| NU-3 protein tyrosine phosphatase | <enzyme> The murine homolog of rat cam tyrosine phosphatase; has an extracellular cell-adhesion-molecule-like domain; mw 211 kD; genbank x82288 Registry number: EC 3.1.3.- Synonym: nu-3 ptp, ptp nu-3 (26 Jun 1999) |
| Dopa-tyrosine sulfotransferase | <enzyme> Active towards tyrosine and dopa isomers except dl-ortho-tyrosine; isolated from rat liver; genbank u38419 Registry number: EC 2.8.2.- (26 Jun 1999) |
| insulin receptor protein-tyrosine kinase | <enzyme> A catalytic protein-tyrosine kinase domain found on the cytoplasmic beta-portion of the insulin receptor. Registry number: EC 2.7.1.- (12 Dec 1998) |
| islet cell antigen-related protein-tyrosine phosphatase | <enzyme> Receptor-like autoantigen found in insulin-dependent diabetes; genbank l76258 Registry number: EC 3.1.3.- Synonym: iar ptp (26 Jun 1999) |
| T-cell protein tyrosine phosphatase | <enzyme> Contains a single ptp domain and possesses a c-terminal region that may play a role in enzymatic regulation and/or targeting to discrete intracellular sites; amino acid sequence known Registry number: EC 3.1.3.- Synonym: tc-ptp (26 Jun 1999) |
| TCK receptor-tyrosine kinase | <enzyme> A member of the eph receptor tyrosine kinase subfamily; expressed during xenopus development; shows 79% amino acid identity to hek2; genbank l43621 Registry number: EC 2.7.1.- Synonym: tck protein (26 Jun 1999) |
| Tec protein-tyrosine kinase | <enzyme> Member of the cytoplasmic ptks of the non-src family; associates with lyn ptk; n-terminal amino acid sequence given in first source Registry number: EC 2.7.1.- Synonym: tec ptk, tec kinase, tec tyrosine kinase (26 Jun 1999) |
| TIE-2 receptor tyrosine kinase | <enzyme> Expressed in developing vascular endothelial cells; unlike tie-1, also expressed in lens epithelium and heart epicardium; has the same organization of amino acid sequence motifs characteristic of tie-1; aa sequence of the intracellular and extracellular regions of tie-1 and tie-2 are 79% and 32% identical, respectively; aa sequence of both kinases given in first source Registry number: EC 2.7.10.- Synonym: tie-2-rtk (26 Jun 1999) |
| tie receptor tyrosine kinase | <enzyme> From human leukaemia cells; expressed in developing vascular endothelial cell; has homology with egf, bfgf, csf-1, pdgf and stem cell factor receptors; ligand and biologic function not known as of 12/92; tie-1 receptor tyrosine kinase is rat homolog of tie receptor tyrosine kinase; aa sequence known Registry number: EC 2.7.10.- Synonym: tie-1 receptor tyrosine kinase, tie-1 rtk (26 Jun 1999) |