| botulinum toxin | <protein> Neurotoxin (50 kD, 7 distinct serotypes) produced by certain strains of Clostridium botulinum. The bacterium produces the toxin as a complex with a haemagglutinin that prevents toxin inactivation in the gut. Proteolysis in the body results in cleavage into two fragments A and B. B binds to gangliosides and may stimulate the endocytosis of fragment A. See: synaptobrevin, tetanus toxin. (18 Nov 1997) |
|---|---|
| botulinum toxin type a | <chemical> A neurotoxin produced by clostridium botulinum. When consumed in contaminated food it can cause paralysis and death. In its purified form, it has been used in the treatment of blepharospasm and strabismus. Pharmacological action: neuromuscular agents. (12 Dec 1998) |
| botulinus toxin | A potent neurotoxin from Clostridium botulinum. Synonym: botulin, botulismotoxin. (05 Mar 2000) |
| botulism toxin | <protein> A toxic byproduct of Clostridium Botulinum that is responsible for the food-borne illness known as botulism. (27 Sep 1997) |
| gamma toxin | <microbiology> Complex toxin (33.4 kD) produced by Staphylococcus aureus. Rabbit erythrocytes are particularly sensitive to lysis by the toxin, but the mechanism is unknown. (18 Nov 1997) |
| paralytic shellfish poisoning toxin carbamoylase | <enzyme> Hydrolytic enzyme from shellfish converts saxitoxin, neosaxitoxin, gonyautoxins 1 - 4 to the corresponding decarbamoyl toxins Registry number: EC 3.1.1.- Synonym: pcp toxin carbamoylase, saxitoxin carbamoylase (26 Jun 1999) |
| pertussis toxin | <protein> Protein complex (ca 117 kD). An A B toxin, the active subunit is a single polypeptide 28 kD), the binding subunit a pentamer (two heterodimers, 23 + 11.7 kD, 11.7 + 22 kD and a monomer (9.3 kD) that binds the heterodimers). The active subunit ADP ribosylates the _ subunit of the inhibitory GTP-binding protein (Gi). Crucial to the pathogenicity of Bordetella pertussis, the causative agent of whooping cough. (18 Nov 1997) |
| cholera toxin | <protein> A multimeric protein toxin from Cholera vibrio. The toxic A subunit activates adenyl cyclase irreversibly by ADP ribosylation of a Gs protein. The B subunit facilitates passage of the A subunit across the cell membrane. (18 Nov 1997) |
| cholera toxin, B subunit-horseradish peroxidase | <chemical> Conjugate of horseradish peroxidase and cholera toxin Synonym: bhrp, horseradish peroxidase-cholera toxin b subunit, cholera toxin-horseradish peroxidase, horseradish peroxidase-cholera toxin, ib4-hrp (26 Jun 1999) |
| cobra toxin | A polypeptide of 62 residues; action on cells is similar to that of melittin in that it promotes disruption of membranes; used as an investigational antirheumatic agent. Synonym: cobra toxin, direct lytic factor of cobra venom. (05 Mar 2000) |
| plant toxin | A substance similar in its properties to an extracellular bacterial toxin. Synonym: plant toxin. Origin: phyto-+ G. Toxikon, poison (05 Mar 2000) |
| Crotalus toxin | <herpetology> The toxin of rattlesnake. (05 Mar 2000) |
| HC toxin reductase | <enzyme> Nadph-dependent enzyme from maise which inactivates the cyclic tetrapeptide, hc toxin, from cochliobolus carbonum; amino acid sequence given in first source Registry number: EC 1.- Synonym: hm1 gene product (26 Jun 1999) |
| scarlet fever erythrogenic toxin | A culture filtrate of lysogenised group A strains of beta-haemolytic streptococci, erythrogenic when inoculated into the skin of susceptible persons, and neutralised by antibodies that appear during scarlet fever convalescence; three immunological types (A, B, and C) are recognised. Synonym: Dick test toxin, erythrogenic toxin, scarlet fever erythrogenic toxin. (05 Mar 2000) |
| Schick test toxin | Corynebacterium diphtheriae toxin diluted so that the inoculated dose (0.1 or 0.2 ml) will contain 1/50 th of guinea pig minimal lethal dose. See: Schick test. Synonym: diagnostic diphtheria toxin. (05 Mar 2000) |