| thalidomide |
A drug used in the treatment of nausea during pregnancy and as a sedative. The use of this drug was discontinued in the 1960s because of severe teratogenic effects. Thalidomide inhibits Tumor Necrosis Factor-alfa-producttion by monocytes and other cells and can be used as a treatment in diseases where TNF-alfa is of pathogenetic importance. Among other diseases thalidomide has been shown to be effective in refractory Crohn
출처: www.gastrolab.net/dictet.htm
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| thalidomide |
"Compound formerly used in medicine as a sedative and antiemetic drug until the discovery that it caused fetal malformations. Thalidomide was found to produce phocomelia ("seal limbs") and other deformities (as absence or malformation of the external ear, fusion defects of the eye, and absence of the normal openings of the gastrointestinal tract) in infants born of mothers who had taken the drug during early pregnancy. ...
출처: www.embassy.org.nz/encycl/t3encyc.htm
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| thalidomide |
Originally reported as an agent that had an adverse effect on fetal limb bud development, its teratogenic activity is mediated by angiogenesis inhibition. Reports on its antitumor activity have resulted in its evaluation in clinical trials in patients with several solid tumors as well as hematopoeitic diseases.
출처: www.jco.org/cgi/glossarylookup
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| thalidomide |
A drug to help morning sickness that was withdrawn in 1961 after it was found to cause limb deformities in babies born to women who had taken it
출처: www.kented.org.uk/ngfl/subjects/history/medhist/pa...
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| thalidomide |
tranquilizing drug that can have a teratogenic effect on the auditory system of the developing embryo when taken by the mother during pregnancy, resulting in congenital hearing loss
출처: www.hearingcenteronline.com/diction_stu.shtml
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