| thiamin pyridinylase | <enzyme> An enzyme catalyzing transfer of a pyridine or other bases into the position of the pyrimidine in thiamin; e.g., thiamin reacting with pyridine produces heteropyrithiamin and 4-methyl-5-(2'-hydroxyethyl)-thiazole. Synonym: pyrimidine transferase, thiaminase I. (05 Mar 2000) |
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| thiamin pyrophosphate | The diphosphoric ester of thiamin, a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. Synonym: aneurine pyrophosphate, cocarboxylase, diphosphothiamin. (05 Mar 2000) |
| thiamin pyrophosphokinase | <enzyme> An enzyme that catalyses the formation of thiamine pyrophosphate from ATP and thiamine. Chemical name: ATP:thiamine pyrophosphotransferase Registry number: EC 2.7.6.2 (12 Dec 1998) |
| thiamin-triphosphatase | <enzyme> An enzyme present in nerve tissue. It catalyses reversibly the formation of thiamine diphosphate and orthophosphate from thiamine triphosphate. Chemical name: Thiamin-triphosphate phosphohydrolase Registry number: EC 3.6.1.28 (12 Dec 1998) |
| thiaminase | 1. An enzyme present in raw fish that destroys thiamin and may produce thiamin deficiency in animals on a diet largely composed of raw fish. 2. A hydrolase cleaving thiamin into a pyrimidine moiety (i.e., 2-methyl-4-amino-5-hydroxymethylpyrimidine) and a thiazole moiety (i.e., 4-methyl-5-(2'-hydroxyethyl)-thiazole); the pyrimidine moiety may appear in the urine as pyramin. Synonym: thiaminase II. (05 Mar 2000) |
| thiaminase I | <enzyme> An enzyme catalyzing transfer of a pyridine or other bases into the position of the pyrimidine in thiamin; e.g., thiamin reacting with pyridine produces heteropyrithiamin and 4-methyl-5-(2'-hydroxyethyl)-thiazole. Synonym: pyrimidine transferase, thiaminase I. (05 Mar 2000) |
| thiaminase II | 1. An enzyme present in raw fish that destroys thiamin and may produce thiamin deficiency in animals on a diet largely composed of raw fish. 2. A hydrolase cleaving thiamin into a pyrimidine moiety (i.e., 2-methyl-4-amino-5-hydroxymethylpyrimidine) and a thiazole moiety (i.e., 4-methyl-5-(2'-hydroxyethyl)-thiazole); the pyrimidine moiety may appear in the urine as pyramin. Synonym: thiaminase II. (05 Mar 2000) |
| thiamine | <chemical> 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride. Chemical name: Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- chloride (12 Dec 1998) |
| thiamine deficiency | A nutritional condition produced by a deficiency of thiamine in the diet, characterised by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the united states most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, beriberi prevalence is very high. (12 Dec 1998) |
| thiamine monophosphate | <chemical> Thiamine dihydrogen phosphate ester. The monophosphate ester of thiamine. Synonym: monophosphothiamine; vitamin b1 monophosphate. Chemical name: Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(2-(phosphonooxy)ethyl)-, chloride (12 Dec 1998) |
| thiamine pyrophosphatase | <enzyme> The coenzyme form of vitamin B1 (thiamine), deficiency of which causes beri beri. Forms the prosthetic group of pyruvate dehydrogenase, _ ketoglutarate dehydrogenase and transketolase, in which it is involved in transfer of a 2 carbon unit. Marker for the trans cisternae of the Golgi complex. (18 Nov 1997) |
| thiamine pyrophosphate | <biochemistry> Co carboxylase. A cofactor that has an unusually acidic carbon atom able to form carbon carbon bonds. Found in pyruvate dehydrogenase and transketolase. (18 Nov 1997) |
| thiamine triphosphate | <chemical> 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(4,6,8,8-tetrahydroxy-3,5,7-trioxa-4,6,8-triphosphaoct-1-yl)thiazolium hydroxide, inner salt, p,p',p''-trioxide. The triphosphate ester of thiamine. In leigh's disease, this compound is present in decreased amounts in the brain due to a metabolic block in its formation. Chemical name: Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(4,6,8,8-tetrahydroxy-3,5,7-trioxa-4,6,8-triphosphaoct-1-yl)-, inner salt, P,P',P''-trioxide (12 Dec 1998) |
| thiamphenicol | <chemical> 2,2-dichloro-n-(2-hydroxy-1-(hydroxymethyl)-2-(4- (methylsulfonyl)phenyl)ethyl)acetamide. A methylsulfonyl analog of chloramphenicol. It is an antibiotic and immunosuppressive agent. Pharmacological action: antibiotics, immunosuppressive agents. Chemical name: Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-(methylsulfonyl)phenyl)ethyl)-, (R-(R*,R*))- (12 Dec 1998) |
| thiamylal | <chemical> A barbiturate that is administered intravenously for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, or for inducing a hypnotic state. Pharmacological action: anaesthetics, intravenous, sedatives, barbiturate. Chemical name: 4,6(1H,5H)-Pyrimidinedione, dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo- (12 Dec 1998) |