| slow virus disease | A disease that follows a slow, progressive course spanning months to years, frequently involving the central nervous system, and ultimately leading to death, such as visna and maedi of sheep, caused by viruses of the subfamily Lentivirinae (family Retroviridae), and subacute sclerosing panencephalitis, seemingly caused by the measles virus; spongiform encephalopathies including kuru of man, scrapie of sheep, and transmissible encephalopathy of mink may also be classified under slow virus disease but their respective aetiologic agents have not been adequately characterised. (05 Mar 2000) |
|---|---|
| slow virus diseases | Diseases of viral origin, characterised by incubation periods of months to years, insidious onset of clinical manifestations, and protracted clinical course. Though the disease process is protracted, viral multiplication may not be unusually slow. Conventional viruses produce slow virus diseases such as subacute sclerosing panencephalitis, progressive multifocal leukoencephalopathy (leukoencephalopathy, progressive multifocal), and aids. Diseases produced by unconventional agents were originally considered part of this group. They are now called prion diseases. (12 Dec 1998) |
| albuminised iron | Iron albuminate, a compound of iron oxide and albumin; rendered soluble by the presence of sodium citrate; occurs as reddish brown, lustrous granules, odourless or nearly so; used in anaemia. (05 Mar 2000) |
| anaemia, iron deficiency | Deficiency of iron results in anaemia because iron is necessary to make haemoglobin, the key molecule in red blood cells responsible for the transport of oxygen. In iron deficiency anaemia, the red cells are unusally small (microcytic) and pale (hypochromic). Characteristic features of iron deficiency anaemia in children include failure to thrive (grow) and increased infections. The treatment of iron deficiency anaemia, whether it be in children or adults, is with iron and iron-containing foods. Food sources of iron include meat, poultry, eggs, vegetables and cereals (especially those fortified with iron). According to the National Academy of Sciences, the Recommended Dietary Allowances of iron are 15 milligrams per day for women and 10 milligrams per day for men. Anaemia characterised by low or absent iron stores, low serum iron concentration, elevated free erythrocyte porphorin, low transferrin saturation, elevated transferrin, low serum ferritin, low haemoglobin concentration or haematocrit, and hypochromic microcytic red blood cells. Symptoms may include pallor, angular stomatitis and other oral lesions, gastrointestinal complaints, retinal haemorrhages and exudates, and thinning and brittleness of the nails. Among the causes of iron-deficiency anaemia are inadequate iron intake, impaired iron absorption, increased blood loss and increased requirements such as infancy, pregnancy, and lactation. (12 Dec 1998) |
| brain iron | <radiology> Normal, Infant: NONE, Adult: globus pallidum, substantia nigra, red nucleus, dentate nucleus, Aging: (adult) and putamen, Degenerative disease, Parkinson disease: putamen, SN compacta, Huntington disease: caudate, putamen, Alzheimer disease: cerebral cortex, Hallervorden-Spatz disease, MS: thalamus, putamen, Others, AVM: malformation and rim, Bleed: rim macrophages, Haemorrhagic CVA: gyral / basal ganglia MRI: low T1 and T2 signal (12 Dec 1998) |
| peptonised iron | A compound of iron oxide and peptone, rendered soluble by the presence of sodium citrate; used in the treatment of iron deficiency anaemia. (05 Mar 2000) |
| molybdenum-iron protein aldehyde oxidoreductase | <enzyme> Related to xanthine oxidase; isolated from desulfovibrio gigas Registry number: EC 1.2.7.- Synonym: mop protein (26 Jun 1999) |
| Weigert's iron haematoxylin stain | <technique> A nuclear staining solution containing haematoxylin, ferric chloride, and hydrochloric acid; useful in combination with von Gieson's stain, especially for demonstrating connective tissue elements or Entamoeba histolytica in sections. (05 Mar 2000) |
| Mowry's colloidal iron stain | <technique> A stain used for demonstrating acid mucopolysaccharides. (05 Mar 2000) |
| Hale's colloidal iron stain | <technique> A stain used to distinguish acid mucopolysaccharides such as hyaluronic acid; may be combined with PAS to also visualise carbohydrate-containing proteins and glycoproteins. (05 Mar 2000) |
| Heidenhain's iron haematoxylin stain | <technique> An iron alum haematoxylin stain used for staining muscle striations and mitotic structures blue-black. (05 Mar 2000) |
| serum iron level | A test that measures the amount of iron (Fe ++) in the blood. The test is performed when iron deficiency is suspected. Normal serum iron is 60 to 170 mcg/dl. Increased levels may be seen in the following: haemochromatosis, haemolysis, haemolytic anaemia, hepatitis, liver necrosis, haemosiderosis, iron poisoning and lead toxicity. Lower than normal levels are seen in chronic GI blood loss, iron deficiency anaemia, insufficient dietary iron, malabsorption, chronic heavy menstrual bleeding, nephrosis and late pregnancy. (27 Sep 1997) |
| spiegel iron | <chemistry> A fusible white cast iron containing a large amount of carbon (from three and a half to six per cent) and some manganese. When the manganese reaches twenty-five per cent and upwards it has a granular structure, and constitutes the alloy ferro manganese, largely used in the manufacture of Bessemer steel. Synonym: specular pig iron, spiegel, and spiegeleisen. Origin: G. Spiegel mirror + E. Iron. Source: Websters Dictionary (01 Mar 1998) |
| nickel-iron hydrogenase | <enzyme> From desulfovibrio multispirans Registry number: EC 1.12.- Synonym: nife hydrogenase, co-induced hydrogenase, co-tolerant hydrogenase (26 Jun 1999) |
| nickel-iron-selenium hydrogenase | <enzyme> From desulfovibrio baculatus Registry number: EC 1.12.- Synonym: nifese hydrogenase (26 Jun 1999) |