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Tay-Sachs carrier <genetics> One who carries the recessive gene that is responsible for Tay-Sachs disease. Genetic testing for this fatal disease is crucial so that Tay-Sachs carriers can be identified and provided with genetic counseling.
(27 Sep 1997)
Tay-Sachs disease <disease> A genetic disorder found in east European Jewish families which can result in early death bu affecting the brain and nerves by causing abnormal lipid metabolism. It is a lysosomal disease in which there is a deficiency of hexosaminidase A, an enzyme that degrades ganglioside GM2.
Symptoms appear at age 3-6 months and include blindness, deafness, seizures, paralysis, dementia, decreased muscle tone and growth retardation. There is no known treatment and most children usually die between 2 and 5 years of age.
Inheritance: autosomal recessive.
(06 Oct 1997)
Tyrode, Maurice <person> U.S. Pharmacologist, 1878-1930.
See: Tyrode's solution.
(05 Mar 2000)
Favre, Maurice <person> French physician, 1876-1954.
See: Gamna-Favre bodies, Nicolas-Favre disease.
(05 Mar 2000)
Lev, Maurice <person> U.S. Pathologist, *1908.
See: Lev's disease, Lev's syndrome.
(05 Mar 2000)
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