| SPA | the bar-shaped typewriter key that introduces spaces when used |
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| SPA | the branch of biology concerned with the effects of outer space on living organisms and the search for extraterrestrial life |
| SPA | someone who seems unable to respond appropriately to reality (as if under the influence of some narcotic drug) |
| SPA | a spacecraft designed to transport people and support human life in outer space |
| SPA | heater consisting of a self-contained (usually portable) unit to warm a room |
| SPA | a helmet worn by astronauts while in outer space |
| SPA | a manned artificial satellite in a fixed orbit designed for scientific research |
| SPA | a 3-dimensional geometric arrangement of the atoms or molecules or ions composing a crystal |
| SPA | the branch of medicine concerned with the effects of space flight on human beings |
| SPA | a manned artificial satellite in a fixed orbit designed for scientific research |
| SPA | a rocket-propelled guided missile that can escape the earth's atmosphere |
| SPA | a technological program intended to explore outer space |