| SCLE | an earthball with a smooth upper surface that is at first buried in sand |
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| SCLE | a family of fungi or order Sclerodermatales with a single-layered peridium |
| SCLE | an order of fungi having a peridium surrounding a gleba (sometimes placed in subclass Homobasidiomycetes) |
| SCLE | a measuring instrument that measures the hardness of materials by penetrating them with a stylus that has a diamond point |
| SCLE | scorpionfishes |
| SCLE | a simple protein found in horny and cartilaginous tissues and in the lens of the eye |
| SCLE | relating to or having sclerosis |
| SCLE | a rare chronic progressive encephalitis caused by the measles virus and occurring primarily in children and young adults |
| SCLE | any pathological hardening or thickening of tissue |
| SCLE | of or relating to the sclera of the eyeball |
| SCLE | relating to or having sclerosis |
| SCLE | whitish fibrous membrane (albuginea) that with the cornea forms the outer covering of the eyeball |