| prostaglandin-E2 9-reductase | <enzyme> Catalyses reversibly an nad+ dependent oxidation of the 9alpha-hydroxyl group of 15-keto-13,14-dihydro-pgf2alpha to 15-keto-13,14-dihydro-pge2; also acts on pga1; sequence data indicates that it is identical with carbonyl reductase (NADPH) (EC 1.1.1.184) Registry number: EC 1.1.1.189 Synonym: 9-ketoprostaglandin reductase, prostaglandin-9-hydroxydehydrogenase, pge2 9-ketoreductase, pge 9-ketoreductase, prostaglandin e2-9-oxoreductase, prostaglandin 9-ketoreductase, prostaglandin e2-9-ketoreductase, 9-hydroxy-pg dehydrogenase, 9-hydroxyprostaglandin dehydrogenase, pge2 9-reductase (26 Jun 1999) |
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| prostaglandin endoperoxides | Precursors in the biosynthesis of prostaglandins and thromboxanes from arachidonic acid. They are physiologically active compounds, having effect on vascular and airway smooth muscles, platelet aggregation, etc. (12 Dec 1998) |
| prostaglandin endoperoxides, synthetic | Synthetic compounds that are analogs of the naturally occurring prostaglandin endoperoxides and that mimic their pharmacologic and physiologic activities. They are usually more stable than the naturally occurring compounds. (12 Dec 1998) |
| prostaglandin endoperoxide synthase | <enzyme> An enzyme complex that catalyses the formation of prostaglandins from the appropriate unsaturated fatty acid, molecular oxygen, and a reduced acceptor. See: cyclooxygenase Chemical name: (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase Registry number: EC 1.14.99.1 (12 Dec 1998) |
| prostaglandin-E synthase | <enzyme> Converts pgh to pge; part of prostaglandin synthase complex Registry number: EC 5.3.99.3 Synonym: prostaglandin r2 e-isomerase, endoperoxide isomerase, prostaglandin endoperoxide e isomerase, prostaglandin h2 e-isomerase, pge2 isomerase, prostaglandin e2 isomerase, pgr2 e-isomerase, prostaglandin h2-prostaglandin e2 isomerase, prostaglandin e isomerase (26 Jun 1999) |
| prostaglandin F2a | <chemical> 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoic acid. A natural prostaglandin f analog that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions. Pharmacological action: abortifacient agents, non-steroidal, oxytocics. Chemical name: Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9alpha,11alpha,13E,15S)- (12 Dec 1998) |
| prostaglandin F2a tromethamine | An oxytocic agent. Synonym: prostaglandin F2a tromethamine. (05 Mar 2000) |
| prostaglandin-F synthase | <enzyme> Catalyses conversion of pgd2 to pgf2alpha; also converts pgh2 to pgf2alpha Registry number: EC 1.1.1.188 Synonym: pgd2 11-keto reductase, pgf synthetase, pgf synthase, prostaglandin d2-NADPH-dependent ketoreductase, prostaglandin f synthetase, pgf2alpha synthase, prostaglandin d2 11-keto reductase (26 Jun 1999) |
| prostaglandin R2 D-isomerase | <enzyme> Prostaglandin d synthase and pgd synthase were non-print entry terms to prostaglandin synthase 1983-91 Registry number: EC 5.3.99.2 Synonym: prostaglandin endoperoxide d-isomerase, prostaglandin h2 d-isomerase, pgd2 isomerase, prostaglandin d2-isomerase, prostaglandin d2 isomerase, pgd synthetase, pgr2 d-isomerase, prostaglandin d synthase, pgd synthase, pgd2 synthase, prostaglandin d2 synthase (26 Jun 1999) |
| adrenergic receptors | Reactive components of effector tissues, most of which are innervated by adrenergic postganglionic fibres of the sympathetic nervous system. Such receptor's can be activated by norepinephrine and/or epinephrine and by various adrenergic drugs; receptor activation results in a change in effector tissue function, such as contraction of arteriolar muscles or relaxation of bronchial muscles; adrenergic receptor's are divided into alpha-receptor's and beta-receptor's, on the basis of their response to various adrenergic activating and blocking agents. Synonym: adrenoceptor, adrenoreceptors. (05 Mar 2000) |
| alpha-adrenergic receptors | Adrenergic receptor's in effector tissues capable of selective activation and blockade by drugs; conceptually derived from the ability of certain agents, such as phenoxybenzamine, to block only some adrenergic receptor's and of other agents, such as methoxamine, to activate only the same adrenergic receptor's. Such receptor's are designated as alpha-receptors. Their activation results in physiological responses such as increased peripheral vascular resistance, mydriasis, and contraction of pilomotor muscles. (05 Mar 2000) |
| ANP clearance receptors | Cell surface proteins that bind atrial natriuretic peptide and ANP fragments without initiating biological action. (05 Mar 2000) |
| ANP receptors | Cell surface receptors for atrial natriuretic peptide that have a single transmembrane spanning element; these have integral kinase and guanylate cyclase domains. (05 Mar 2000) |
| B-cell antigen receptors | In the primary immune response immunoglobulin D and monomeric immunoglobulin M are the B-cell antigen receptors. On memory B-cells, other immunoglobulin molecules can serve as antigen receptors. (05 Mar 2000) |
| beta-adrenergic receptors | Adrenergic receptor's in effector tissues capable of selective activation and blockade by drugs; conceptually derived from the ability of certain agents, such as propranolol, to block only some adrenergic receptor's and of other agents, such as isoproterenol, to activate only the same adrenergic receptor's. Such receptor's are designated as beta-receptors. Their activation results in physiological responses such as increases in cardiac rate and force of contraction (b1), and relaxation of bronchial and vascular smooth muscle (b2). (05 Mar 2000) |