| mice, inbred hrs | Homozygous, permanently near-hairless mice which lose their hair at about 10 days of age. (12 Dec 1998) |
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| mice, inbred mdx | A strain of mice arising from a spontaneous mutation (mdx) in inbred c57bl mice. This mutation is x chromosome-linked and produces viable homozygous animals that lack the muscle protein dystrophin, have high serum levels of muscle enzymes, and possess histological lesions similar to human muscular dystrophy. The histological features, linkage, and map position of mdx make these mice a worthy animal model of duchenne muscular dystrophy. (12 Dec 1998) |
| mice, inbred mrl lpr | A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the mrl/lpr is a useful model to study behavioural and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents. (12 Dec 1998) |
| mice, inbred nod | A strain of non-obese diabetic mice developed in japan that has been widely studied as a model for T-cell-dependent autoimmune insulin-dependent diabetes mellitus in which insulitis is a major histopathologic feature, and in which genetic susceptibility is strongly MHC-linked. (12 Dec 1998) |
| mice, inbred sencar | Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to uv radiation tumourigenesis with single high-dose, but not chronic low-dose, exposures. Sencar (sensitive to carcinogenesis) mice are used in research as an animal model for tumour production. (12 Dec 1998) |
| mice, inbred strains | Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. (12 Dec 1998) |
| inbred | Denoting populations (groups, genetic lines, etc.) descended over several generations almost exclusively from a small set of ancestors, and hence having a high rate of consanguinity, often occult. (05 Mar 2000) |
| inbred strain | Any strain of animal or plant obtained by a breeding strategy that tends to lead to homozygosity. Such breeding strategies include brother sister mating and back crossing of offspring with parents. See: congenic. (18 Nov 1997) |