| perforation | 1. The act of boring or piercing through a part. 2. A hole made through a part or substance. Origin: L. Perforare = to pierce through (18 Nov 1997) |
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| intestinal perforation | <surgery> This surgical emergency involves rupture of the wall of the intestine. Intestinal perforation results in severe abdominal pain intensified by movement. Later symptoms include fever and chills. Underlying causes include appendicitis, gastrointestinal cancer and diverticulitis. (10 Jan 1998) |
| oesophageal perforation | <radiology> Usually in neonates, upper oesophagus frequently affected, then NG tube dissects posteriorly, relatively benign in neonates CXR findings: pneumothorax, pneumomediastinum, abnormal distance between NG tube and trachea on lateral view, NG tube does not terminate in stomach, thin irregular tract (with contrast) vs. Large regular tract (tracheo-oesophageal fistula), pleural effusion, patchy infiltrates see: oesophageal trauma (12 Dec 1998) |
| tympanic membrane perforation | An opening in the tympanic membrane usually caused by trauma. There are four general categories: compression injuries (the most common and usually the result of a blow to the ear); instrumentation injuries (the second most common, usually inadvertent, caused often by cotton swabs or bobby-pins); burn-slag injuries (frequently seen in industry, from hot metal from machines or welding); and blast injuries (usually seen during war or as a result of terrorist bombing). In the absence of infection, most traumatic tympanic membrane perforations heal spontaneously. Persistent perforation is usually a manifestation of tubotympanitis, an inflammation of the eustachian tube and tympanic cavity (middle ear). (12 Dec 1998) |
| uterine perforation | Penetration through the uterine wall. (12 Dec 1998) |
| aberrant bile ducts | Small duct's occasionally present in the ligaments of the liver or originating from the surface of the liver. (05 Mar 2000) |
| bile | <gastroenterology> A greenish-yellow fluid secreted by the liver and stored in the gallbladder. Bile plays an important role in the intestinal absorption of fats. Bile is secreted by the liver and contains cholesterol, bile salts and waste products such as bilirubin. Bile salts aid in the digestion of fats. Bile passes out of the liver via the bile duct where it is stored in the gallbladder and released in response to a fat-containing meal. (27 Sep 1997) |
| bile acid 3alpha-sulfate sulfohydrolase | <enzyme> Used for determination of serum 3alpha-sulfated bile acids; converts 3alpha-sulfated bile acids into 3beta-hydroxy bile acids Registry number: EC 3.1.6.- Synonym: 3alpha-sulfated bile acid sulfohydrolase, ba-3s sulfohydrolase (26 Jun 1999) |
| bile acid 7alpha-dehydratase | <enzyme> Enzyme in the bacterial bile acid 7alpha-dehydroxylation pathway Registry number: EC 4.2.1.- Synonym: c24 bile acid 7alpha-dehydratase, ba7alphad, baie gene product (26 Jun 1999) |
| bile acid 7 alpha-dehydroxylase | <enzyme> Mechanism is questionable: cholic acid - deoxycholic acid - chenodeoxycholic acid - lithocholic acid Registry number: EC 1.14.- Synonym: 7 alpha-dehydroxylase, bile acid 7-dehydroxylase, bile acid 7-alpha-dehydroxylase, bai a1, bai a2, bai a3, cholic acid 7alpha-dehydroxylase (26 Jun 1999) |
| bile acid-CoA ligase | <enzyme> Catalyses the synthesis of all bile acid-coas; in order to measure the activity of all bile acids, the bile acid is coupled with c(14)-glycine and measured with bile acid-CoA glycine-taurine n-acetyltransferase Registry number: EC 6.2.1.- (26 Jun 1999) |
| bile acids | Steroid acids found in bile; e.g., taurocholic and glycocholic acid's, used when biliary secretion is inadequate and for biliary colic. Their physiological roles include fat emulsification. Their synthesis is reduced in disorders of the peroxisomes. (05 Mar 2000) |
| bile acids and salts | <chemical> Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones. Pharmacological action: cholagogues and choleretics, gastrointestinal agents. (12 Dec 1998) |
| bile acid tolerance test | A sensitive test of hepatic dysfunction; following oral administration of labelled or unlabelled bile acid, the measured fractional disappearance rate or 10-minute retention is measured. (05 Mar 2000) |
| bile alcohol | One of a group of polyhydroxylated alcohols derived from cholestane. (05 Mar 2000) |