| Oncocerca | A genus of parasitic nematodes whose organisms live and breed in skin and subcutaneous tissues. Onchocercal microfilariae may also be found in the urine, blood, or sputum. (12 Dec 1998) |
|---|---|
| oncocyte | Askenazy cell |
| oncocytic hepatocellular tumour | <tumour> Primary hepatic carcinoma in which malignant hepatocytes are intersected by fibrous lamellated bands. Synonym: oncocytic hepatocellular tumour. (05 Mar 2000) |
| oncocytoma | <tumour> A glandular tumour composed of large cells with cytoplasm that is granular and eosinophilic due to the presence of abundant mitochondria; occurs uncommonly in the kidney, salivary glands, and endocrine glands. Synonym: oxyphil adenoma. Origin: onco-+ G. Kytos, cell, + -oma, tumour (05 Mar 2000) |
| oncofetal | Relating to tumour-associated substances present in foetal tissue, as oncofetal antigens. (05 Mar 2000) |
| oncofetal antigens | Tumour-associated antigen's present in foetal tissue but not in normal adult tissue, including alpha-fetoprotein and carcinoembryonic antigen. (05 Mar 2000) |
| oncofetal marker | A tumour marker produced by tumour tissue and by foetal tissue of the same type as the tumour, but not by normal adult tissue from which the tumour arises. (05 Mar 2000) |
| oncogen | <oncology, pharmacology> Synonym for carcinogen, an agent causing cancer. (18 Nov 1997) |
| oncogene | <molecular biology, oncology> Mutated and/or overexpressed version of a normal gene of animal cells (the proto-oncogene) that in a dominant fashion can release the cell from normal restraints on growth and thus alone or in concert with other changes, convert a cell into a tumour cell. (18 Nov 1997) |
| oncogene protein gp140(v-fms) | Transforming glycoprotein coded by the fms oncogene from the susan mcdonough strain of feline sarcoma virus (sm-fesv). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (csf-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms). (12 Dec 1998) |
| oncogene protein p21(ras) | Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumours. (12 Dec 1998) |
| oncogene protein p55(v-myc) | Transforming protein coded by myc oncogenes. The v-myc protein has been found in several replication-defective avian retrovirus isolates which induce a broad spectrum of malignancies. (12 Dec 1998) |
| oncogene protein p65(gag-jun) | Transforming protein coded by jun oncogenes (genes, jun). This is a gag-onc fusion protein of about 65 kD derived from avian sarcoma virus. V-jun lacks a negative regulatory domain that regulates transcription in c-jun. (12 Dec 1998) |
| oncogene protein pp60(v-src) | <chemical> Tyrosine-specific protein kinase encoded by the v-src oncogene of rous sarcoma virus. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its n-terminal glycine. Chemical name: Kinase (phosphorylating), protein pp60src (12 Dec 1998) |
| oncogene proteins | Proteins coded by oncogenes. They include proteins resulting from the fusion of an oncogene and another gene (oncogene proteins, fusion). (12 Dec 1998) |