| protein N-terminal acetyltransferase | <enzyme> From saccharmyces cerevisiae; encodes a catalytic subunit of an n-terminal acetyltransferase; ard1 and nat1 proteins are subunits of this enzyme Registry number: EC 2.3.1.- Synonym: nat1 gene protein, saccharomyces, yeast protein n-terminal acetyltransferase, n-terminal protein acetyltransferase, ard1 protein (26 Jun 1999) |
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| HIV long-terminal repeat | Regulatory sequences important for viral replication that are located on each end of the HIV genome. The ltr includes the HIV enhancer, promoter, and other sequences. Specific regions in the ltr include the negative regulatory element (nre), nf-kappa b binding sites , sp1 binding sites, tata box, and trans-acting responsive element (tar). The binding of both cellular and viral proteins to these regions regulates HIV transcription. (12 Dec 1998) |
| small bowel disease involving terminal ileum | <radiology> Crohn's, TB, Yersinia (12 Dec 1998) |
| NH2-terminal | <biochemistry> The end of a protein or polypeptide chain with the unattached amino group or the aminoacyl residue containing it. Each amino acid in the chain has an amino group on one side, which is attached to the carboxyl group (COOH group) of the previous amino acid, and a carboxyl group on the other side (which is attached to the amino group of the next amino acid). The other end of the polypeptide chain is called the carboxyl terminal. Synonym: NH2-terminal. (14 Aug 2000) |
| Deiters' terminal frames | Platelike structures in the organ of Corti uniting the outer phalangeal cells with Hensen's cells. (05 Mar 2000) |
| direct terminal repeat | A particular sequence of nucleotides which appears on both ends of a DNA or RNA molecule. (09 Oct 1997) |
| ileitis, terminal | Crohn's disease, a chronic inflammatory disease of the intestine involving only the end of the small intestine (the terminal ileum). Crohn's disease affects primarily the small and large intestines but which can occur anywhere in the digestive system between the mouth and the anus. Named after burrill crohn who described the disease in 1932. The disease often strikes persons in their teens or early twenties. It tends to be chronic, recurrent with periods of remission and exacerbation. In the early stages. It causes small scattered shallow crater-like areas (erosions) called apthous ulcers in the inner surface of the bowel. With time, deeper and larger ulcers develop, causing scarring and stiffness of the bowel and the bowel becomes increasingly narrowed, leading to obstruction. Deep ulcers can puncture holes in the bowel wall, leading to infection in the abdominal cavity (peritonitis) and in adjacent organs abdominal pain, diarrhoea, vomiting, fever, and weight loss can be symptoms. Crohn's disease can be associated with reddish tender skin nodules, and inflammation of the joints, spine, eyes, and liver. Diagnosis is by barium enema, barium X-ray of the small bowel, and colonoscopy. Treatment includes medications for inflammation, immune suppression, antibiotics, or surgery. (12 Dec 1998) |
| telomere terminal transferase | <enzyme> From oxytricha nova; adds two to seven tandem repeats of the sequence ggggtttt to the 3' end of oligonucleotide primers ending in repeats of g4t4 and always adds the repeats in the proper phase Registry number: EC 2.7.7.- (26 Jun 1999) |
| terminal | 1. Forming or pertaining to an end, placed at the end. 2. A termination, end or extremity. Origin: L. Terminalis (18 Nov 1997) |
| terminal addition enzyme | <enzyme> A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyses the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukaemias in man. Chemical name: Nucleoside-triphosphate:DNA deoxynucleotidylexotransferase Registry number: EC 2.7.7.31 (12 Dec 1998) |
| terminal artery | <anatomy, artery> An artery with insufficient anastomoses to maintain viability of the tissue supplied if occlusion of the artery occurs. Synonym: terminal artery. (05 Mar 2000) |
| terminal bar | Obsolete name for zonula occludens (tight junction). (18 Nov 1997) |
| terminal boutons | The somewhat enlarged, often club-shaped endings by which axons make synaptic contacts with other nerve cells or with effector cells (muscle or gland cells). As isolated, by homogenizing brain or spinal cord, they contain acetylcholine and the related enzymes. Terminals contain neurotransmitters of various kinds, sometimes more than one. These can be demonstrated by chemical analysis and immunocytochemical methods. See: synapse. Synonym: axonal terminal boutons, end-feet, neuropodia, pieds terminaux, synaptic boutons, synaptic endings, synaptic terminals, terminal boutons, bouton terminaux. (05 Mar 2000) |
| terminal bronchiole | The end of the nonrespiratory conducting airway; the lining is simple columnar or cuboidal epithelium without mucous goblet cells; most of the cells are ciliated, but a few nonciliated serous secreting cells occur. Synonym: bronchiolus terminalis. (05 Mar 2000) |
| terminal care | Medical and nursing care of patients in the terminal stage of an illness. (12 Dec 1998) |