| LACN | local area communications network |
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| LAN | local area network; long-acting neuroleptic [agent] |
| LAS | laboratory automation system; lateral amyotrophic sclerosis; laxative abuse syndrome; left anterior-... |
| LCBF | local cerebral blood flow |
| LCGU | local cerebral glucose utilization |
| local circuit theory | <physiology> A generally accepted model for neuronal conduction, by which depolarisation of a small region of a neuronal plasma membrane produces transmembrane currents in the neighbouring regions, tending to depolarise them. As the sodium channels are voltage gated, the depolarisation causes further channels to open, thus propagating the action potential. (18 Nov 1997) |
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| local death | Death of a part of the body or of a tissue by necrosis. (05 Mar 2000) |
| local epilepsy | Epilepsy of various aetiologies characterised by focal seizures or secondarily generalised tonic-clonic seizures. Ictal symptoms are often related to the brain region where the seizure begins focally. Synonym: cortical epilepsy, local epilepsy, partial epilepsy. (05 Mar 2000) |
| local excitatory state | Increased irritability of a nerve fibre or muscle fibre which is produced by an ineffective electrical stimulus; summation of the stimuli may occur, resulting in a propagated impulse if two or more subliminal stimuli are applied in rapid succession. (05 Mar 2000) |
| local flap | A flap transferred to an adjacent area. (05 Mar 2000) |
| local glomerulonephritis | Glomerulonephritis affecting only part of a glomerulus or glomeruli. Synonym: local glomerulonephritis. (05 Mar 2000) |
| local hormone | A metabolic product secreted by one set of cells that affects the function of nearby cells; an autacoid; e.g., prostaglandins and neurotransmitters. (05 Mar 2000) |
| local immunity | A natural or acquired immunity to certain infectious agents, as manifested by an organ or a tissue, as a whole or in part. (05 Mar 2000) |
| local nerve block | Infiltration of a local anesthetic around a peripheral nerve so as to produce anesthesia in the area supplied by the nerve. (16 Dec 1997) |
| local reaction | A reaction which occurs at the point of entrance of an infecting organism or of an injection, as in the Arthus phenomenon. Synonym: local reaction. (05 Mar 2000) |
| local sign | <clinical sign> The characteristic of a sensation that permits distinguishing it from another sensation by locating its position in space. (05 Mar 2000) |
| local stimulant | A stimulant whose action is confined to the part to which it is applied. (05 Mar 2000) |
| local symptom | A symptom of limited extent, caused by disease of a particular organ or part. (05 Mar 2000) |
| local syncope | Limited numbness in a part, especially of the fingers; one of the symptoms, usually associated with local asphyxia, of Raynaud's disease. (05 Mar 2000) |
| local tetanus | The most benign type of tetanus; the muscles in close proximity to an infected wound develop persistent involuntary contractions, often with transient, intense superimposed spasms triggered by various stimuli. The more distal upper extremity muscles are most often affected; gradual but complete recovery is typical. (05 Mar 2000) |