| AOA | American Osteopathic Association; Administration on Aging; Alpha Omega Alpha Honor Society; American... |
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| PAL | pathology laboratory; peptidyl-alpha-hydroxyglycine alpha-amidating lysine phase alteration plane; p... |
| ROC | Receptor Operated Channel |
| VSC | Voltage Sensitive Channel |
| Ca2+-blocker | calcium channel blocker |
| 5 alpha-androstane-3 beta,17 beta-diol 6 alpha-hydroxylase | <enzyme> Requires NADPH, found in rat prostatic microsomes Registry number: EC 1.14.13.- Synonym: artdl 6 alpha-hydroxylase (26 Jun 1999) |
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| 5 alpha-androstane 3 beta,17 beta-diol 7 alpha-hydroxylase | <enzyme> Requires NADPH, found in rat prostate microsomes Registry number: EC 1.14.13.- Synonym: artdl 7 alpha-hydroxylase (26 Jun 1999) |
| 5 alpha-dihydroprogesterone 3 alpha-hydroxysteroid oxidoreductase | <enzyme> Catalyses conversion of 5 alpha-dihydroprogesterone to 3 alpha -hydroxy-5 alpha-pregnane-20-one Registry number: EC 1.1.1.- Synonym: 5-dp-3 alpha-hso, NADPH-5 alpha-dihydroprogesterone 3 alpha-hydroxysteroid oxidoreductase, alpha-hsor (26 Jun 1999) |
| 5 beta-cholestane-3 alpha,7 alpha-diol 26-hydroxylase | <enzyme> Nadp-dependent Registry number: EC 1.14.13.- (26 Jun 1999) |
| 7 alpha-hydroxy-4-cholesten-3-one-12 alpha monooxygenase | <enzyme> Liver microsomal enzyme active in conversion of cholesterol to cholic acid; introduces a 12 alpha-hydroxyl group into the steroid nucleus of cholesterol Registry number: EC 1.14.99.- Synonym: 7-hco-monooxygenase, hco 12 alpha-hydroxylase (26 Jun 1999) |
| calcium channel | <physiology> A membrane channel that is specific for calcium. It is a voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorised as l, t, n, or p types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. (12 May 2002) |
| calcium channel agonist | <pharmacology> Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in vascular smooth muscle and/or cardiac muscle cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture. (12 Dec 1998) |
| calcium channel antagonist | <pharmacology> A class of drugs that act by selective inhibition of calcium ion influx through or across cell membranes or on the release and binding of calcium in intracellular pools. Calcium channel blockers are used primarily in the treatment of certain heart conditions and stroke. As they are inducers of vascular and other smooth muscle relaxation, they are also used in the treatment of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms. Synonym: calcium antagonist, calcium channel-blocker, slow channel-blocking agent. (12 May 2002) |
| calcium channel-blocker | <pharmacology> A class of drugs that act by selective inhibition of calcium ion influx through or across cell membranes or on the release and binding of calcium in intracellular pools. Calcium channel blockers are used primarily in the treatment of certain heart conditions and stroke. As they are inducers of vascular and other smooth muscle relaxation, they are also used in the treatment of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms. Synonym: calcium antagonist, calcium channel-blocker, slow channel-blocking agent. (12 May 2002) |
| gated ion channel | <physiology> Transmembrane proteins of excitable cells, that allow a flux of ions to pass only under defined circumstances. Channels may be either voltage gated, such as the sodium channel of neurons or ligand gated such as the acetylcholine receptor of cholinergic synapses. Channels tend to be relatively ion specific and allow fluxes of typically 1000 ions to pass in around 1ms, they are thus much faster at moving ions across a membrane than transport ATPases. (05 May 1997) |
| voltage-gated channel | A class of ion channel's that open and close in response to change in the electrical potential across the plasma membrane of the cell; voltage-gated Na+ c.'s are important for conducting action potential along nerve cell processes. (05 Mar 2000) |
| voltage gated ion channel | <physiology> A transmembrane ion channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. These channels are essential for neuronal signal transmission and for intracellular signal transduction. See: sodium channel. (18 Nov 1997) |
| channel | A furrow, gutter, or groovelike passageway. See: canal. Origin: L. Canalis (05 Mar 2000) |
| channel forming ionophore | <chemistry> An ionophore that makes an amphipathic pore with hydrophobic exterior and hydrophilic interior. most known types are cation selective. (18 Nov 1997) |
| channel gating | <physiology> Small currents in the membrane just prior to the increase in ionic permeability, due to the movement of charged particles within the membrane. So called because they open the gates for current flow through ion channels. (20 Mar 1998) |