| AIA | allylisopropylacetamide; amylase inhibitor activity; anti-immunoglobulin antibody; anti-insulin anti... |
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| AIG | anti-immunoglobulin |
| CIg | intracytoplasmic immunoglobulin |
| cIgM | cytoplasmic immunoglobulin M |
| CIT | citrate; combined intermittent therapy; conjugated-immunoglobulin technique; crossed intrinsic trans... |
| serum immunoglobulin electrophoresis | A test that detects and measures the various immunoglobulins in the blood. In the normal assay no monoclonal antibodies are detected. In multiple myeloma and chronic lymphocytic leukaemia a single clone of lymphocytes can produce one type of immunoglobulin that is detected in the electrophoresis as monoclonal (made by one cell clone). (27 Sep 1997) |
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| immunoglobulin | <immunology> A specific protein substance that is produced by plasma cells to aid in fighting infection. Some immunoglobulins (gamma globulin) take part in various immune responses of the body to bacteria or foreign substances (allergens, tumour or transplanted tissue). Examples include IgG, IgM, IgA, IgD and IgE. (30 Mar 1998) |
| immunoglobulin A | <immunology> Major class of immunoglobulin of external secretions in mammals, also found in serum and body fluids such as tears and saliva and in the respiratory, reproductive, urinary and gastrointestinal tracts. Immunoglobulin A protects the bodys mucosal surfaces from infection and in secretions, it is found as a dimer (400 kD) joined by a short J chain and linked to a secretory portion or transport piece. In serum found as a monomer (170 kD). Immunoglobulin A is the main mechanism for providing local immunity against infections in the gut or respiratory tract and may act by reducing the binding between an immunoglobulin A coated micro organism and a host epithelial cell. Present in human colostrum but not transferred across the placenta. Have heavy chains. (30 Mar 1998) |
| immunoglobulin allotypes | Hereditary serologic types based on antigenic differences in the light and heavy chains of immunoglobulins due to allelic genes in the gene loci coding the chains. The inv system applies to the kappa light chains, the gm system applies to the heavy chains of IgG. (12 Dec 1998) |
| immunoglobulin class switching | Gene rearrangement of the b-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing. (12 Dec 1998) |
| immunoglobulin constant region | That region of the immunoglobulin (antibody) molecule that is invariable in its amino acid sequence within any class of immunoglobulins. It confers the biological specificity to the ig and is grossly species specific. It comprises the c-terminus half of the light chains and three quarters or more of the heavy chains, all of the fc fragment, and the c-terminus half of the fab fragment. (12 Dec 1998) |
| immunoglobulin D | <immunology> This immunoglobulin (184 kD) is present at a low level (3-400 mcg/ml) but is a major immunoglobulin on the surface of B lymphocytes where it may play a role in antigen recognition. Its structure resembles that of immunoglobulin G but the heavy chains are of the delta type. (30 Mar 1998) |
| immunoglobulin domains | Structural units of immunoglobulin heavy or light chains that are composed of approximately 110 amino acids. Light chains of an immunoglobulin are composed of one constant domain and one variable domain. Heavy chains are composed of either three or four constant domains and one variable domain. (05 Mar 2000) |
| immunoglobulin E | <immunology> Class of immunoglobulin (188 kD) associated with immediate type hypersensitivity reactions and helminth infections. Present in very low amounts in serum and mostly bound to mast cells and basophils that have an immunoglobulin E specific Fc receptor (FceR). Immunoglobulin E has a high carbohydrate content and is also present in external secretions. Heavy chain of epsilon type. (30 Mar 1998) |
| immunoglobulin electrophoresis | <immunology, investigation> A test that detects and measures the various immunoglobulins in the blood. In the normal assay no monoclonal antibodies are detected but in multiple myeloma and chronic lymphocytic leukaemia a single clone of lymphocytes can produce one type of immunoglobulin that is detected in the electrophoresis as monoclonal (made by one cell clone). (30 Mar 1998) |
| immunoglobulin idiotypes | Unique, genetically controlled determinants present on antibodies whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the variable regions of both immunoglobin polypeptide chains. (12 Dec 1998) |
| immunoglobulin inv allotypes | Hereditary allotypic markers associated with the light chain of IgG. (12 Dec 1998) |
| immunoglobulin isotypes | The classes of immunoglobulins found in any species of animal. In man there are nine classes that migrate in five different groups in electrophoresis; they each consist of two light and two heavy protein chains, and each group has distinguishing structural and functional properties. (12 Dec 1998) |
| immunoglobulin joining region | Segment of light and heavy chains of mouse and human immunoglobulins where the genes for the variable region upstream join those of the constant region downstream (an important part of the antibody diversity mechanism). In the joining region of the light chain are the genes coding for amino acids 96 to 107. (12 Dec 1998) |
| immunoglobulin M | <immunology> An immunoglobulin M molecule (970 kD) is built up from five immunoglobulin G type monomers joined together, with the assistance of J chains, to form a cyclic pentamer. Immunoglobulin M binds complement and a single molecule bound to a cell surface can lyse that cell. Immunoglobulin M is usually produced first in an immune response before immunoglobulin G. The human red cell isoantibodies are immunoglobulin M antibodies. Heavy chain (mu chain) is rather larger than the heavy chains of other immunoglobulins. (30 Mar 1998) |
| immunoglobulin G |
an antibody-containing substance produced by human plasma cells in diseased central nervous system plaques. Levels of IgG are increased in the cerebrospinal fluid of most MS patients.
출처: www.swedish.org/15141.cfm
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| immunoglobulin g.’s |
the genes coding for immunoglobulin heavy and light chains, which are organized in three loci coding for κ light chains, λ light chains, and heavy chains found on human chromosomes 2, 22, and 14, respectively. These genes undergo several DNA rearrangements during the differentiation of stem cells into B cells and plasma cells, permitting synthesis of the various immunoglobulin classes.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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