| HLA | histocompatibility leukocyte antigen; histocompatibility locus antigen; homologous leukocyte antibod... |
|---|---|
| HLA-LD | human lymphocyte antigen-lymphocyte defined |
| HLA-SD | human lymphocyte antigen-serologically defined |
| HTC | hepatoma cell; hepatoma tissue culture; homozygous typing cell |
| PLT | pancreatic lymphocytic infiltration; platelet; primed lymphocyte test; primed lymphocyte typing; psi... |
| HLA-b7 antigen | <immunology> Human histocompatibility (HLA) surface antigen encoded by the b locus on chromosome 6. There is a weak association between the presence of the HLA-b7 antigen and the diseases of narcolepsy and idiopathic haemochromatosis. HLA-b7 is in linkage disequilibrium with HLA-a3 and HLA-dr2. (12 Dec 1998) |
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| HLA-b8 antigen | <immunology> Human histocompatibility (HLA) surface antigen encoded by the b locus on chromosome 6. It is in linkage disequilibrium with HLA-a1 and HLA-dr3. This explains the fact that though HLA-b8 was originally associated with several diseases, including coeliac disease, dermatitis herpetiformis, and myasthenia gravis, their association with HLA-dr3 is now considered more significant. (12 Dec 1998) |
| HLA-b antigens | <immunology> Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus b of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-b27, -b7, -b8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic t lymphocytes. (12 Dec 1998) |
| HLA-c antigens | <immunology> Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the c locus on chromosome 6. They have significantly lower immunogenicity than the HLA-a and -b determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma). (12 Dec 1998) |
| HLA complex | <immunology> The major histocompatibility complex in humans. See: human lymphocyte antigens. (05 Mar 2000) |
| HLA-d antigens | <immunology> Human immune-response or class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-d locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -dr, -dq and -dp designations, of which HLA-dr is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune aetiology. (12 Dec 1998) |
| HLA-dp antigens | <immunology> A group of the d-related HLA antigens (human) found to differ from the dr antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. (12 Dec 1998) |
| HLA-dq antigens | <immunology> A group of the d-related HLA antigens found to differ from the dr antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. (12 Dec 1998) |
| HLA-dr1 antigen | <immunology> Human immune-response, d-related antigen encoded by the d locus on chromosome 6 and found on lymphoid cells. (12 Dec 1998) |
| HLA-dr2 antigen | <immunology> Human immune-response, d-related antigen encoded by the d locus on chromosome 6 and found on lymphoid cells. It is in linkage disequilibrium with HLA-a3 and HLA-b7 and is strongly associated with goodpasture syndrome, multiple sclerosis, and narcolepsy. (12 Dec 1998) |
| HLA-dr3 antigen | <immunology> Human immune-response, d-related antigen encoded by the d locus on chromosome 6 and found on lymphoid cells. It is in linkage disequilibrium with HLA-a1 and HLA-b8. The HLA-dr3 antigen is strongly associated with coeliac disease, grave's disease, dermatitis herpetiformis, early-age onset myasthenia gravis, systemic lupus erythematosus, juvenile diabetes, and opportunistic infections in aids. (12 Dec 1998) |
| HLA-dr4 antigen | <immunology> Human immune-response, d-related antigen encoded by the d locus on chromosome 6 and found on lymphoid cells. It is strongly associated with rheumatoid arthritis and juvenile diabetes. (12 Dec 1998) |
| HLA-dr5 antigen | <immunology> Human immune-response, d-related antigen encoded by the d-locus on chromosome 6 and found on lymphoid cells. It is associated with kaposi sarcoma in aids and juvenile rheumatoid arthritis. (12 Dec 1998) |
| HLA-dr6 antigen | <immunology> Human immune-response, d-related antigen encoded by the d locus on chromosome 6 and found on lymphoid cells. (12 Dec 1998) |
| HLA-dr7 antigen | <immunology> Human immune-response, d-related antigen encoded by the d locus on chromosome 6 and found on lymphoid cells. It is strongly associated with coeliac disease and psoriasis vulgaris. (12 Dec 1998) |