| globin insulin | A rapidly acting form of insulin which is a clear solution and may be administered intravenously as well as subcutaneously; may be mixed with longer acting forms of insulin to extend the duration of effect. Onset of effect occurs in 1/2 to 1 hour, peak effects are observed in 2 to 3 hours, and the duration of effect is about 5 to 7 hours. Synonym: globin insulin. (05 Mar 2000) |
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| globin zinc insulin | A sterile solution of insulin modified by the addition of zinc chloride and globin; it contains 40 or 80 units per ml; duration of action is about 18 hours. Human insulin, a protein that has the normal structure of insulin produced by the human pancreas, prepared by recombinant DNA techniques and by semisynthetic processes. Immunoreactive insulin (IRI), that portion of insulin in blood measured by immunochemical methods for the hormone; presumed to represent the free (unbound) and biologically active fraction of total blood insulin. Isophane insulin, a modified form of insulin composed of insulin, protamine, and zinc; an intermediately acting preparation used for the treatment of diabetes mellitus. Synonym: NPH insulin. (05 Mar 2000) |
| Globocephalus | A genus of hookworm (subfamily Uncinariinae, family Ancylostomatidae) consisting of about five species, found chiefly in the small intestine of pigs. The species Globocephalus urosubalatus, of worldwide distribution, is a common hookworm of wild and domestic pigs. (05 Mar 2000) |
| globoid cell | A large cell of mesodermal origin that is found clustered in the intracranial tissues in globoid cell leukodystrophy. (05 Mar 2000) |
| globoid cell leukodystrophy | <radiology> Dysmyelinating disease, autosomal recessive, usually presents by 1 yr, specific enzyme deficiency identified, rapid spontaneous nystagmus, poikilothermia Synonym: Krabbe leukodystrophy (12 Dec 1998) |
| globose | Nearly spherical. (09 Oct 1997) |
| globoside | <biochemistry> An organic macromolecule, a type of oligomeric glycoside, containing a number of different sugar groups which is found in the red blood cells of certain mammals, including humans, pigs, and sheep. (09 Oct 1997) |
| globoside galactosyltransferase | <enzyme> Mouse kidney microsome enzyme which participates in the formation of galactosylgloboside (stage-specific embryonic antigen-3 glycolipid) Registry number: EC 2.4.1.- Synonym: udpgalactose-globoside beta 1-3 galactosyltransferase, gb4-galactosyltransferase, gb4 synthetase, beta-1,3-galnac-tf (26 Jun 1999) |
| globosides | Glycosphingolipids containing n-acetylglucosamine (paragloboside) or n-acetylgalactosamine (globoside). Globoside is the p antigen on erythrocytes and paragloboside is an intermediate in the biosynthesis of erythrocyte blood group abh and p 1 glycosphingolipid antigens. The accumulation of globoside in tissue, due to a defect in hexosaminidases a and b, is the cause of sandhoff disease. (12 Dec 1998) |
| globosus nucleus | A group of two or three small masses of gray substance in the white central core of the cerebellum, medial to the emboliform nucleus; receives axons of Purkinje cells of the intermediate area of the cerebellar cortex; axons of these cells exit the cerebellum via the superior cerebellar peduncle. Synonym: nucleus globosus, spherical nucleus. (05 Mar 2000) |
| globotriaosylceramide | <biochemistry> A type of glycolipid compound which accumulates in the blood vessel walls of people with Fabry disease as a result of a deficiency in alpha-galactosidase A, a type of galactosidase enzyme. (09 Oct 1997) |
| globular | Globe-shaped; having the form of a ball or sphere; spherical, or nearly so; as, globular atoms. Globular chart, a chart of the earth's surface constructed on the principles of the globular projection. <geometry> Globular projection, a perspective projection of the surface of a hemisphere upon a plane parallel to the base of the hemisphere, the point of sight being taken in the axis produced beyond the surface of the opposite hemisphere a distance equal to the radius of the sphere into the sine of 45 deg . Globular sailing, sailing on the arc of a great circle, or so as to make the shortest distance between two places; circular sailing. Origin: Cf. F. Globulaire. Source: Websters Dictionary (01 Mar 1998) |
| globular actin | <protein> A short polypeptide chain of 375 amino acids which is the monomeric unit of the protein actin (one of the two proteins involved in muscle contraction). Many units of G actin join together in a polymer to make an actin filament. (09 Oct 1997) |
| globular heart | Abnormally smooth arcuate contours of the heart due either to disease of the ventricles or to a false cardiac appearance produced by excessive pericardial fluid. Synonym: globular heart. (05 Mar 2000) |
| globular leukocyte | A type of wandering cell with a small, round nucleus found in the epithelium and lamina propria of the intestinal mucosa of many animals; its cytoplasm contains large eosinophilic globules or droplets. (05 Mar 2000) |