| 영문 | hyaline membrane disease | 한글 | 유리질막병 |
|---|---|---|---|
| 설명 | 허파 성숙도의 미숙으로 허파꽈리를 팽창시키는 물질(표면활성제)이 부족하여 호흡곤란이 초래되는 병으로서 미숙아에 호발하는데, 출생시 임신기간보다도 허파 성숙 정도가 더 관여된다. 단일 병으로서는 사망률이 가장 높으며(약 30%), 신생아의 대표적인 병이다. 임상적으로는 미숙아, 생후 6~8시간내 호흡곤란증세 출현과 생후 24~48시간의 증상 악화, 생후 2~3일간 인공적으로 산소를 공급하지 않으면 호흡을 계속시킬 수가 없으며 점점더 산소의 공급 의존도가 높아지며, 동맥혈액속의 산소농도가 내려가고 이산화탄소의 농도가 높으며, 흉부 방사선 소견을 참작하여 진단한다. 환아는 숙련된 간호 인력과 첨단 의료 장비가 설치된 신생아 집중 치료실에서 치료하여야 한다. 예후는 증세의 경중에 따라 다르고 사망률은 30~50% 된다. 어떤 아기에 있어서는 치료 후에 눈이나 기관지허파 계통에 장애를 일으키는 산소중독증이 보고되고 있다. |
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| PBPs | Penicillin-Binding Proteins |
|---|---|
| GABAT, GABA-T | gamma-aminobutyric acid transaminase |
| PVM | pneumonia virus of mice; proteins, vitamins, and minerals |
| RPSP | reference preparation for serum proteins |
| FENa, FeNa | Fractional Excretion of Sodium ; Volume의 개념을 제거하여 좀 더 정확한 신장의 농축 능력을 평가, &n... |
| GABA pathway | The pathway that ultimately converts 4-aminobutyrate to succinate; succinate is then converted to alpha-ketoglutarate, via the tricarboxylic acid cycle, which is then acted upon by glutamate dehydrogenase; glutamate is then decarboxylated to reform 4-aminobutyrate; an important pathway for those cells which make this neuroactive molecule. Synonym: GABA pathway. (05 Mar 2000) |
|---|---|
| GABA permease | <chemical> From aspergillus nidulans; uga4 is from saccharomyces cerevisiae Synonym: gamma-amino-n-butyrate permease, 4-aminobutyric acid permease, uga4 protein, uga4 gene product (26 Jun 1999) |
| GABA receptor | <physiology> Ligand gated chloride ion channel forming receptor opened by gamma aminobutyric acid. Two distinct types: A and B. A receptor: One of a family of neurotransmitter receptors with fast intrinsic ion channels that includes the glycine receptor and the nicotinic acetylcholine receptor. Distinct from another major receptor family, the muscarininc acetylcholine receptor and rhodopsin, with no intrinsic ion channel. The A receptor is specifically blocked by bicuculline. It consists of two pairs of protein chains forming an A2B2 complex, the A chains bind benzodiazepine and the B chains bind GABA. The 4 subunits are thought to form a tight group with the chloride channel in the middle. There is considerable similarity between the amino acid sequences of the receptor subunits and those of the nicotinic acetylcholine receptor suggesting that both receptors are derived from some evolutionary ancestor. See: amino acid receptor superfamily. B receptor: Brain receptor (80 kD) for the inhibitory neurotransmitter gamma amino butyric acid. Differs from the A receptor both in agonist specificity (baclofen is a specific agonist) and its effects on cells. It modulates intracellular calcium levels through a Go mediated effect on N type calcium channels and also lowers intracellular cAMP levels by an effect on adenylyl cyclase, thereby reducing the secretion of catecholamines. (05 Jan 1998) |
| receptors, gaba | Cell-surface proteins that bind gaba with high affinity and trigger changes that influence the behaviour of cells. Gaba-a receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. Gaba-b receptors act through g-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for l-baclofen. (12 Dec 1998) |
| receptors, gaba-a | Cell surface proteins which bind gaba and control an integral membrane chloride channel. Gaba-a receptors are the most prevalent inhibitory neurotransmitter receptors in the brain. Several isoforms have been cloned, and they belong to a superfamily which includes nicotinic receptors, glycine receptors, and 5ht-3 receptors. Most gaba-a receptors have separate modulatory sites sensitive to benzodiazepines and to barbiturates. (12 Dec 1998) |
| receptors, gaba-b | Cell surface proteins which bind gaba and influence cells via interactions with g-proteins. Gaba-b receptors are pharmacologically characterised by their insensitivity to the blocker bicuculline and sensitivity to the agonist l-baclofen. They are found both presynaptically and postsynaptically, and act variously by inhibition of adenylate cyclase, activation of phospholipase a2, activation of potassium channels, and inactivation of voltage-activated calcium channels. (12 Dec 1998) |
| active transport | <biochemistry, chemistry> Transport of ions, nutrients or other molecules into a cell against a concentration gradient, this requires the expenditure of energy through ATP hydrolysis. (06 May 1997) |
| anterograde transport | Movement of material from the cell body of a neuron into axons and dendrites retrograde axoplasmic transport also occurs). (18 Nov 1997) |
| atrial transport function | The role of the atria in filling and stretching the ventricles by their presystolic contraction, without which the force of ventricular contraction and hence the cardiac output may significantly decrease. (05 Mar 2000) |
| axonal transport | Directed transport of organelles and molecules along a nerve cell axon. Transport can be anterograde (from the cell body) or retrograde (toward the cell body). (alberts et al., molecular biology of the cell, 3d ed, pg3) (12 Dec 1998) |
| axoplasmic transport | Transport by way of flow of axoplasm toward cell soma (retrograde) or toward axon terminal (anterograde). (05 Mar 2000) |
| biological transport | The movement of materials (including biochemical substances and drugs) across cell membranes and epithelial layers, usually by passive diffusion. (12 Dec 1998) |
| biological transport, active | The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy. (12 Dec 1998) |
| vectorial transport | <physiology> Transport of an ion or molecule across an epithelium in a certain direction (e.g. absorption of glucose by the gut). Vectorial transport implies a nonuniform distribution of transport proteins on the plasma membranes of two faces of the epithelium. (06 Mar 2000) |
| paracellular transport | Solvent movement across an epithelial cell layer through the tight junctions between cells. Compare: transcellular transport. (05 Mar 2000) |