| New World leishmaniasis | A grave disease caused by Leishmania braziliensis braziliensis, endemic in southern Mexico and Central and South America, except for the equatorial region of Chile; the organism does not invade the viscera, and the disease is limited to the skin and mucous membranes, the lesions resembling the sores of cutaneous leishmaniasis caused by L. Mexicana or L. Tropica; the chancrous sores heal after a time, but some months or years later, fungating and eroding forms of ulceration may appear on the tongue and buccal or nasal mucosa; many variants of the disease exist, marked by differences in distribution, vector, epidemiology, and pathology, which suggest that it may in fact be caused by a number of closely related aetiological agents. See: espundia. Synonym: American leishmaniasis, leishmaniasis americana, nasopharyngeal leishmaniasis, New World leishmaniasis. (05 Mar 2000) |
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| new yellow enzyme | The d-amino-acid oxidase found in yeast, a flavoenzyme, which contains FAD as coenzyme instead of FMN as does NADPH dehydrogenase; so-called to distinguish it from Warburg's old yellow enzyme. Compare: amino acid oxidases. (05 Mar 2000) |
| new zealand | A group of islands in the South Pacific Ocean. New Zealand flax. <botany> A myrtaceous shrub (Leptospermum scoparium) of new Zealand and Australia, the leaves of which are used as a substitute for tea. Source: Websters Dictionary (01 Mar 1998) |
| New Zealand mice | Inbred strains of mice, either black (NZB) or white (NZW), unique among strains used in experimental immunology because of their proclivity to spontaneous immunologic abnormalities and disorders including systemic lupus erythematosus similar to that found in humans. (05 Mar 2000) |
| investigational new drug | Status given an experimental drug after the FDA approves an application for testing it in people. (09 Oct 1997) |
| investigational new drug application | An application that must be submitted to a regulatory agency (the FDA in the united states) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (12 Dec 1998) |
| burns, first degree | A first degree burn is superficial and has similar characteristics to a typical sun burn. The skin is red in colour and sensation is intact. In fact, it is usually somewhat painful. (12 Dec 1998) |
| ventriculography, first-pass | Radionuclide ventriculography where a bolus of radionuclide is injected and data are recorded from one pass through the heart ventricle. Left and right ventricular function can be analyzed independently during this technique. First-pass ventriculography is preferred over gated blood pool imaging for assessing right ventricular function. (12 Dec 1998) |
| Mendel's first law | Factors that affect development retain their individuality from generation to generation, do not become contaminated when mixed in a hybrid, and become sorted out from one another when the next generation of gametes is formed. Synonym: Mendel's first law. (05 Mar 2000) |
| mirror, first or front surface | <microscopy> An optical mirror on which the reflecting surface is applied to the front surface of the mirror instead of to the back, that is, to the first surface of incidence. (05 Aug 1998) |
| pregnancy trimester, first | Period of pregnancy from the first day of the last normal menstrual period through the completion of 14 weeks (98 days) of gestation. (12 Dec 1998) |
| healing by first intention | Healing by fibrous adhesion, without suppuration or granulation tissue formation. Synonym: primary adhesion, primary union. (05 Mar 2000) |
| schneiderian first rank symptoms | Those symptom's that, when present, indicate that the diagnosis of schizophrenia is likely, provided that organic or toxic aetiology is ruled out: delusion of control, thought broadcasting, thought withdrawal, thought insertion, hearing one's thoughts spoken aloud, auditory hallucinations that comment on one's behaviour, and auditory hallucinations in which two voices carry on a conversation. Synonym: first rank symptoms, schneiderian first rank symptoms. (05 Mar 2000) |
| Schneider's first rank symptoms | Those symptom's that, when present, indicate that the diagnosis of schizophrenia is likely, provided that organic or toxic aetiology is ruled out: delusion of control, thought broadcasting, thought withdrawal, thought insertion, hearing one's thoughts spoken aloud, auditory hallucinations that comment on one's behaviour, and auditory hallucinations in which two voices carry on a conversation. Synonym: first rank symptoms, schneiderian first rank symptoms. (05 Mar 2000) |
| double first | <engineering> A degree of the first class both in classics and mathematics. One who gains at examinations the highest honor both in the classics and the mathematics. Source: Websters Dictionary (01 Mar 1998) |