| DHSS | Department of Health and Social Security; dihydrostreptomycin sulfate |
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| ACR | abnormally contracting region; absolute catabolic rate; acriflavine; adenomatosis of colon and rectu... |
| FUR | 5-fluorouracil and radiation; fluorouracil riboside; fluorouridine; follow-up report; furin membrane... |
| MMWR | Morbidity and Mortality Weekly Report |
| PR | by way of the rectum [Lat. per rectum]; far point [of accommodation] [Lat. punctum remotum]; palindr... |
| chemical change | A process in which one or more substances are changed into one or more different substances. (09 Oct 1997) |
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| minimal-change disease | <nephrology> A disorder of the kidneys which largely affects the glomerulus, the blood filtering structure. This disorder is one common cause of nephrotic syndrome, minimal glomerular changes, in children affecting 2 to 3 children per 100,000 population under age 16 in the USA. Minimal change disease is also seen rarely in adults. The cause is unknown but may be related to an autoimmune illness. It is marked by oedema, albuminuria, and an increase in cholesterol in the blood, but otherwise with fairly good renal function. Tubular epithelium is vacuolated by cholesterol droplets, but the glomeruli show only that the foot processes of the glomerular epithelial cells are fused, probably secondary to the proteinuria; the cause of the increased glomerular permeability to plasma protein is unknown. Risk factors include a history for a immune disorder, recent immunisation or a bee sting. Diagnosis is made by renal biopsy. Treatment include systemic corticosteroids which are usually quite effective in curing this disease. Other medications include chlorambucil and cyclophosphamide. In most cases, a moderate protein diet (1 gram protein per Kg body weight per day) will be recommended. Salt (sodium) restriction can be helpful to reduce swelling and vitamin D is usually supplemented. Synonym: lipoid nephrosis (27 Sep 1997) |
| minimal-change nephrotic syndrome | <nephrology> A disorder of the kidneys which largely affects the glomerulus, the blood filtering structure. This disorder is one common cause of nephrotic syndrome, minimal glomerular changes, in children affecting 2 to 3 children per 100,000 population under age 16 in the USA. Minimal change disease is also seen rarely in adults. The cause is unknown but may be related to an autoimmune illness. It is marked by oedema, albuminuria, and an increase in cholesterol in the blood, but otherwise with fairly good renal function. Tubular epithelium is vacuolated by cholesterol droplets, but the glomeruli show only that the foot processes of the glomerular epithelial cells are fused, probably secondary to the proteinuria; the cause of the increased glomerular permeability to plasma protein is unknown. Risk factors include a history for a immune disorder, recent immunisation or a bee sting. Diagnosis is made by renal biopsy. Treatment include systemic corticosteroids which are usually quite effective in curing this disease. Other medications include chlorambucil and cyclophosphamide. In most cases, a moderate protein diet (1 gram protein per Kg body weight per day) will be recommended. Salt (sodium) restriction can be helpful to reduce swelling and vitamin D is usually supplemented. Synonym: lipoid nephrosis (27 Sep 1997) |
| conformational change | <cell biology> Alteration in the shape usually the tertiary structure of a protein as a result of alteration in the environment pH, temperature, ionic strength) or the binding of a ligand (to a receptor) or binding of substrate (to an enzyme). (18 Nov 1997) |
| Crooke's hyaline change | Replacement of cytoplasmic granules of basophil cells of the anterior pituitary by homogenous hyaline material; a characteristic finding in Cushing's syndrome, but usually not present in the cells of a basophil adenoma. Synonym: Crooke's hyaline degeneration. (05 Mar 2000) |
| social change | Social process whereby the values, attitudes, or institutions of society, such as education, family, religion, and industry become modified. It includes both the natural process and action programs initiated by members of the community. (12 Dec 1998) |
| enthalpy change | <chemistry> In a reaction, this is more or less equal to the difference between the energy put into breaking bonds and the enery gained from new bond formation. (13 Oct 1997) |
| epigenetic change | <biology> Any changes in an organism brought about by alterations in the action of genes are called epigenetic changes. Epigenetic transformation refers to those processes which cause normal cells to become tumour cells without the occurrence of any mutations. (07 May 1998) |
| fatty change | The appearance of microscopically visible droplets of fat in the cytoplasm of cells. See: fatty degeneration. Synonym: fatty change. (05 Mar 2000) |
| life change events | Those occurrences, including social, psychological, and environmental, which require an adjustment or effect a change in an individual's pattern of living. (12 Dec 1998) |
| air pollutants, environmental | Air pollutants which affect environmental conditions. (12 Dec 1998) |
| carcinogens, environmental | Carcinogenic substances that are found in the environment. (12 Dec 1998) |
| national environmental policy act | A federal law enacted in 1969 that requires all federal agencies to consider and analyse the environmental impacts of any proposed action. NEPA requires an environmental impact statement for major federal actions significantly affecting the quality of the environment. NEPA requires federal agencies to inform and involve the public in the agency's decision making process and to consider the environmental impacts of the agency's decision. (05 Dec 1998) |
| draft environmental impact statement | (DEIS) A draft statement of environmental effects. Section 102 of the National Environmental Policy Act requires a DEIS for all major federal actions. The DEIS is released to the public and other agencies for comment and review. (05 Dec 1998) |
| environmental assessment | (EA) A public document that analyzes a proposed federal action for the possibility of significant environmental impacts. The analysis is required by NEPA. If the environmental impacts will be significant, the federal agency must then prepare an environmental impact statement. (05 Dec 1998) |