| new yellow enzyme | The d-amino-acid oxidase found in yeast, a flavoenzyme, which contains FAD as coenzyme instead of FMN as does NADPH dehydrogenase; so-called to distinguish it from Warburg's old yellow enzyme. Compare: amino acid oxidases. (05 Mar 2000) |
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| New York Heart Association classification | A functional classification to assess cardiovascular disability. Class I: patients with cardiac disease without limitation of physical activity. Ordinary activity does not cause symptoms. Class II: patients with cardiac disease with slight limitation of activity; comfortable at rest. Ordinary physical activity results in fatigue, palpitation, dyspnea or angina. Class III: patients with cardiac disease producing marked limitation of activity: comfortable at rest. Less than ordinary physical activity causes symptoms. Class IV: patients with cardiac disease resulting in inability to carry on any physical activity without discomfort. Symptoms may be present even at rest. (05 Mar 2000) |
| new zealand | A group of islands in the South Pacific Ocean. New Zealand flax. <botany> A myrtaceous shrub (Leptospermum scoparium) of new Zealand and Australia, the leaves of which are used as a substitute for tea. Source: Websters Dictionary (01 Mar 1998) |
| New Zealand mice | Inbred strains of mice, either black (NZB) or white (NZW), unique among strains used in experimental immunology because of their proclivity to spontaneous immunologic abnormalities and disorders including systemic lupus erythematosus similar to that found in humans. (05 Mar 2000) |
| investigational new drug | Status given an experimental drug after the FDA approves an application for testing it in people. (09 Oct 1997) |
| investigational new drug application | An application that must be submitted to a regulatory agency (the FDA in the united states) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (12 Dec 1998) |
| Arneth formula | The normal, approximate ratio of polymorphonuclear neutrophils, based on the number of lobes in the nuclei, as follows: 1 lobe, 5%; 2 lobes, 35%; 3 lobes, 41%; 4 lobes, 17%; 5 lobes, 2%. (05 Mar 2000) |
| Bazett's formula | A formula for correcting the observed Q-T interval in the electrocardiogram for cardiac rate: corrected Q-T = Q-T sec/✓R -R sec. (05 Mar 2000) |
| Bernhardt's formula | <nutrition> A formula used to calculate the ideal weight, in kilograms, for an adult; it is the height in centimeters times the chest circumference in centimeters divided by 240. (14 Aug 2000) |
| Black's formula | A translation of Pignet's formula into British measurements: F = (W + C) -H; F is the empirical factor, W is the weight in pounds, C the chest girth in inches at full inspiration, and H the height in inches; a man is classed as very strong when F is over 120, strong between 110 and 120, good 100 to 110, fair 90 to 100, weak 80 to 90, very weak under 80. (05 Mar 2000) |
| Broca's formula | A fully developed man (30 years old) should weigh as many kilograms as he is centimeters in height over and above 1 meter. (05 Mar 2000) |
| Van Slyke's formula | The value obtained when the square root of the urine flow (when below 2 ml/min) is multiplied by the urine urea concentration and divided by the whole blood urea concentration; represents an old empirical adjustment for the effect of low urine flow on urea excretion; sometimes corrected for body size by dividing by some function of body weight or surface area. Later, plasma concentration was substituted for blood concentration in the calculation. The normal value is about 54 ml/min per 1.73 m2 in an adult person. Synonym: Van Slyke's formula. (05 Mar 2000) |
| Mall's formula | A formula for determining the age (in days) of a human embryo; calculated as the square root of its length (measured from vertex to breech) in millimeters multiplied by 100. (05 Mar 2000) |
| Ranke's formula | A = grams of albumin per liter of a serous fluid: then, A = (sp. Gr. -1000) × 0.52 -5.406. (05 Mar 2000) |
| rational formula | In chemistry, a formula that indicates the constitution as well as the composition of a substance. (05 Mar 2000) |