| delayed hypersensitivity | <immunology> Hypersensitivity (increased reaction by the body to a foreign substance such as an antigen or allergen) that does not appear until 24 to 48 hours after the body is exposed to the foreign substance. (09 Oct 1997) |
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| delayed type hypersensitivity | <immunology> Hypersensitivity (increased reaction by the body to a foreign substance such as an antigen or allergen) that does not appear until 24 to 48 hours after the body is exposed to the foreign substance. (09 Oct 1997) |
| drug hypersensitivity | Immunologically mediated adverse reactions to medicinal substances used legally or illegally. (12 Dec 1998) |
| immediate hypersensitivity | An exaggerated immune response mediated by antibodies, in particular IgE. See: allergy. (05 Mar 2000) |
| immediate hypersensitivity reaction | An immune response mediated by antibody, usually IgE, which occurs within minutes after a second encounter with an antigen, resulting in the release of histamine and subsequent swelling and vasodilation. (05 Mar 2000) |
| tuberculin-type hypersensitivity | A local or generalised response that begins 24 to 48 hours after exposure to an antigen. See: cell-mediated reaction. Synonym: contact hypersensitivity, delayed hypersensitivity, late reaction, tuberculin-type hypersensitivity. (05 Mar 2000) |
| type III hypersensitivity reaction | An immunologic category of diseases evoked by the deposition of antigen-antibody or antigen-antibody-complement complexes on cell surfaces, with subsequent involvement of breakdown products of complement, platelets, and polymorphonuclear leukocytes, and development of vasculitis; nephritis is common. Arthus phenomenon and serum sickness are classic examples, but many other disorders, including most of the connective tissue disease's, may belong in this immunologic category; immune complex disease's can also occur during a variety of disease's of known aetiology, such as subacute bacterial endocarditis. See: autoimmune disease. Synonym: immune complex disorder, type III hypersensitivity reaction. (05 Mar 2000) |
| food hypersensitivity | Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens ingested in food. (12 Dec 1998) |
| acceptor site | The ribosomal binding site for the aminoacyl-tRNA during protein synthesis. (05 Mar 2000) |
| acceptor splicing site | Boundary between the right end of an intron and the left end of the adjacent exon. Synonym: acceptor splicing site. (05 Mar 2000) |
| active site | <chemistry> A specific region of an enzyme where a substrate binds and catalysis takes place (binding site). (06 May 1997) |
| allosteric site | A specific site on a multi-subunit enzyme or other protein that is not the substrate binding site, but that when reversibly bound by an effector, induces a conformational change in the protein, altering its catalytic or binding properties. (12 Dec 1998) |
| amidation site | <molecular biology> A C terminus consensus sequence, required for C terminus amidation of peptides. Consensus is glycine, followed by 2 basic amino acids (arg or lys). (18 Nov 1997) |
| antibody combining site | <immunology> In immune network theory, an idiotope, an antigenic site of an antibody that is responsible for that antibody binding to an antigenic determinant (epitope). Also used of the site on a ligand molecule to which a cell surface receptor binds. (18 Nov 1997) |
| antigen-binding site | <immunology> In immune network theory, an idiotope, an antigenic site of an antibody that is responsible for that antibody binding to an antigenic determinant (epitope). Also used of the site on a ligand molecule to which a cell surface receptor binds. (18 Nov 1997) |