| DNA-directed DNA polymerase | <enzyme> DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair. Chemical name: Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) Registry number: EC 2.7.7.7 (12 Dec 1998) |
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| arthroscopic knee repair | <orthopaedics> A fibreoptic procedure, known as arthroscopy, is used in the surgical repair of any of several knee ligaments including the anterior cruciate ligament (ACL), lateral or medial meniscus, lateral collateral or medial collateral ligament. Recovery from this procedure is based largely on the ligament repaired and can be highly variable. (27 Sep 1997) |
| recombinatorial repair | The incorporation of corresponding DNA of a DNA segment from an identical DNA molecule for the purpose of replacing a damaged segment of DNA. (05 Mar 2000) |
| repair | 1. To restore to a sound or good state after decay, injury, dilapidation, or partial destruction; to renew; to restore; to mend; as, to repair a house, a road, a shoe, or a ship; to repair a shattered fortune. "Secret refreshings that repair his strength." (Milton) "Do thou, as thou art wont, repair My heart with gladness." (Wordsworth) 2. To make amends for, as for an injury, by an equivalent; to indemnify for; as, to repair a loss or damage. "I 'll repair the misery thou dost bear." (Shak) Synonym: restore, recover, renew, amend, mend, retrieve, recruit. Origin: F. Reparer, L. Reparare; pref. Re- re- + parare to prepare. See Pare, and cf. Reparation. Source: Websters Dictionary (01 Mar 1998) |
| repair enzyme | <enzyme, molecular biology> An enzyme that can catalyze the repair of damaged DNA; e.g., DNA ligase. (05 Mar 2000) |
| repair nuclease | <enzyme, molecular biology> Class of enzymes involved in DNA repair. It includes endonucleases that recognise a site of damage or an incorrect base pairing and cut it out and exonucleases that remove neighbouring nucleotides on one strand. These are then replaced by a DNA polymerase. (18 Nov 1997) |
| chemical repair | Conversion of a free radical to a stable molecule. (05 Mar 2000) |
| mismatch repair | <molecular biology> A DNA repair system that detects and replaces wrongly paired, mismatched, bases in newly replicated DNA. E. Coli has a mismatch correction enzyme coded for by three genes mutH, mutL and mutS, that is directed to the newly synthesised strand and removes a segment of that strand including the incorrect nucleotide. The gap is then filled by DNA polymerase. (18 Nov 1997) |
| hernia repair | <surgery> The surgical repair of a hernia. This surgery can be done under local or general anaesthesia. May be performed using a conventional incision or using a fibreoptic laparoscope. (27 Sep 1997) |
| SOS repair | A system that repairs severely damaged bases in DNA by base excision and replacement, even if there is no template to guide base selection. This process is a last resort for repair, and is often the cause of mutations. Synonym: error-prone repair. (05 Mar 2000) |
| dental prosthesis repair | The process of reuniting or replacing a broken or worn dental prosthesis or its part. (12 Dec 1998) |
| denture repair | The process of reuniting or replacing broken or worn parts of a denture. (12 Dec 1998) |
| error-prone repair | <molecular biology> A type of DNA repair which occurs when both nucleotides in a base pair are missing, such that it is not possible to maintain accuracy. In general, the repair proteins replace the missing nucleotides randomly. The idea is that bad DNA is better than no DNA at all. (06 Mar 1998) |
| excision repair | <molecular biology> Mechanism for the repair of environmental damage to one strand of DNA (loss of purines due to thermal fluctuations, formation of pyrimidine dimers by UV irradiation). The site of damage is recognised, excised by an endonuclease, the correct sequence is copied from the complementary strand by a polymerase and the ends of this correct sequence are joined to the rest of the strand by a ligase. The term is sometimes restricted to bacterial systems where the polymerase also acts as endonuclease. (11 Nov 1997) |
| A-DNA | A form of DNA in which the helix is right-handed and the overall appearance is short and broad. (05 Mar 2000) |