| dihydrobenzophenanthridine oxidase | <enzyme> Copper-containing oxidase from sanguinaria canadensis; converts dihydrophenanthridines to the corresponding alkaloids, sanguinarine or chelerythrine; requires oxygen, does not contain flavins or pyridine nucleotides; inhibited by thiols Registry number: EC 1.3.3.- Synonym: dihydrosanguinarine oxidase, dihydronorsanguinarine oxidase, dihydrochelerythrine oxidase (26 Jun 1999) |
|---|---|
| dihydrobiopterin | Precursor to tetrahydrobiopter, a required cofactor for a number of enzymes, including the biosynthesis of l-tyrosine; the inability to synthesise dihydrobiopterin can result in a form of malignant hyperphenylalaninaemia. (05 Mar 2000) |
| dihydrobiopterin reductase | <enzyme> An enzyme that catalyses the reduction of 6,7-dihydropteridine to 5,6,7,8-tetrahydropteridine. Chemical name: NAD(P)H:6,7-dihydropteridine oxidoreductase Registry number: EC 1.6.99.7 (12 Dec 1998) |
| dihydroceramide desaturase | <enzyme> Catalyses conversion of dihydroceramide to ceramide Registry number: EC 1.3.1.- (26 Jun 1999) |
| dihydrocodeine tartrate | 6-Hydroxy-3-methoxy-N-methyl-4,5-epoxymorphinan bitartrate;an analgesic derivative of codeine, about one-sixth as potent as morphine; a narcotic antitussive. (05 Mar 2000) |
| dihydrocodeinone | <chemical> Narcotic analgesic related to codeine, but more potent and more addicting by weight. It is used also as cough suppressant. Pharmacological action: analgesics, opioid, antitussive agents, narcotics. Chemical name: Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)- (12 Dec 1998) |
| dihydrocortisol 3alpha-oxidoreductase | <enzyme> Forms 3alpha,5beta tetrahydrocortisol; prefers NADPH Registry number: EC 1.1.1.- Synonym: dhc-3-oxidoreductase (26 Jun 1999) |
| dihydrocortisone | 17a,21-Dihydroxy-5b-pregnane-3,11,20-trione;a metabolite of cortisone, reduced at the 4,5 double bond. (05 Mar 2000) |
| dihydroergocornine | An ergot alkaloid derivative prepared by the hydrogenation of ergocornine and less toxic than the latter. See: dihydroergotoxine mesylate. (05 Mar 2000) |
| dihydroergocristine | An ergot alkaloid derivative prepared by the hydrogenation of ergocristine and less toxic than the latter. See: dihydroergotoxine mesylate. (05 Mar 2000) |
| dihydroergocryptine | An ergot alkaloid derivative prepared by the hydrogenation of ergocryptine and less toxic than the latter. See: dihydroergotoxine mesylate. (05 Mar 2000) |
| dihydroergotamine | <chemical> 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione. A derivative of ergotamine prepared by the catalytic hydrogenation of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine. Pharmacological action: analgesics, non-narcotic, vasoconstrictor agents. Chemical name: Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha,10alpha)- (12 Dec 1998) |
| dihydroergotoxine | <chemical> Dihydroergotoxine. A mixture of three different ergotaman-3',6',18-triones, dihydroergocornine, dihydroergocristine, and dihydroergocryptine. It has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. The combination of the methanesulfonate salts of these alkaloids is dihydroergotoxine mesylate (see ergoloid mesylates). Pharmacological action: adrenergic alpha-antagonists, dopamine agonists, neuroprotective agents, nootropic agents. Chemical name: Ergotoxine, dihydro- (12 Dec 1998) |
| dihydroergotoxine mesylate | A mixture of dihydroergocornine methanesulfate, dihydroergocristine methanesulfate, and dihydroergocryptine methane sulfate; used as an alpha-adrenergic blocking agent for relief of cardiovascular insufficiency. (05 Mar 2000) |
| dihydroflavanol 4-reductase | <enzyme> Isolated from flowers of dahlia varibilis; requires NADPH as a cofactor; catalyses the transfer of pro-s hydrogen of NADPH to the substrate; pH optima 6.0 for flavanones and 6.8 for dihydroflavonols Registry number: EC 1.1.1.- Synonym: 3-hydroxyflavanone 4-reductase, dhf reductase, dihydroflavonol-4-reductase, dihydroflavanol reductase (26 Jun 1999) |